Gas transfer and blood compatibility of asymmetric polyimide hollow fiber

We have fabricated an asymmetric polyimide hollow fiber for use as a membrane oxygenator. A dry/wet phase inversion process has been applied to a spinning process to prepare the hollow fiber. The fiber structure consisted of a complete defect-free skin layer and a porous substructure characterized by the presence of an open-cell structure and macrovoids. The outer diameter was 480 μm with a wall thickness of 50 μm. Transfer rates of O2 and CO2 in the asymmetric polyimide fiber were 2.3 × 10-5 and 1.1 × 10-4 (cm3(STP)/(cm2s cmHg)), respectively, which were four times higher than those measured in the polydimethylsiloxane (PDMS) fiber of the presentlyavailable membrane oxygenator. The (QO2 /QN2)selectivity of the polyimide fiber was 4.9, indicating that the surface skin layer is essentially defect-free. The blood compatibility of the polyimide hollow fiber has been evaluated in vitro and in vivo. The polyimide had an excellent blood compatibility when compared with PDMS.

[1]  H. Izutani,et al.  Successful experimental multiorgan transplant from non-heart-beating donors using percutaneous cardiopulmonary support. , 1998, ASAIO journal (1992).

[2]  Y Nosé,et al.  Development of a silicone hollow fiber membrane oxygenator for ECMO application. , 1998, ASAIO journal.

[3]  T. Sueda,et al.  Development of an intravascular pumping oxygenator using a new silicone membrane. , 2008, Artificial Organs.

[4]  H. Kawakami,et al.  Gas permeability and selectivity through asymmetric polyimide membranes , 1996 .

[5]  H. Kawakami,et al.  Gas transport properties in thermally cured aromatic polyimide membranes , 1996 .

[6]  I. Sakuma,et al.  Development of a membrane oxygenator for ECMO using a novel fine silicone hollow fiber. , 1996, ASAIO journal (1992).

[7]  I. Cheifetz,et al.  Successful Use of Extracorporeal Membrane Oxygenation in the Treatment of Acute Chest Syndrome in a Child With Severe Sickle Cell Anemia , 1996, ASAIO journal.

[8]  R. Hetzer,et al.  Extracorporeal Membrane Oxygenation as a Bridge to Cardiac Transplantation in Children. , 1996, Artificial organs.

[9]  H. Kawakami,et al.  Gas transfer and in vitro and in vivo blood compatibility of a fluorinated polyimide membrane with an ultrathin skin layer. , 1996, ASAIO journal (1992).

[10]  E. Leonard,et al.  Light Microscopic Visualization of Plasma Intrusion Into Microporous Hollow Fibers , 1995, ASAIO journal (1992).

[11]  H. Kawakami,et al.  Gas transport properties of soluble aromatic polyimides with sulfone diamine moieties , 1995 .

[12]  H. Kawakami,et al.  Synthesis of aromatic polyimides with sulfone diamine moieties for a novel membrane oxygenator. , 1995, ASAIO journal (1992).

[13]  A. Hoffman,et al.  Platelet and monoclonal antibody binding to fibrinogen adsorbed on glow-discharge-deposited polymers. , 1995, Journal of biomedical materials research.

[14]  L. Mockros,et al.  Design and evaluation of a new, low pressure loss, implantable artificial lung. , 1994, ASAIO journal (1992).

[15]  D. W. Fried,et al.  Oxygen transfer efficiency of three microporous polypropylene membrane oxygenators , 1991, Perfusion.

[16]  S. Goodman,et al.  The effects of substrate-adsorbed albumin on platelet spreading. , 1991, Journal of biomaterials science. Polymer edition.

[17]  S. Goodman,et al.  Platelet shape change and cytoskeletal reorganization on polyurethaneureas. , 1989, Journal of biomedical materials research.

[18]  R. Albrecht,et al.  Redistribution of the fibrinogen receptor of human platelets after surface activation , 1984, The Journal of cell biology.