Restoration of chaperone-mediated autophagy in aging liver improves cellular maintenance and hepatic function

[1]  A. Cuervo,et al.  Constitutive activation of chaperone-mediated autophagy in cells with impaired macroautophagy. , 2008, Molecular biology of the cell.

[2]  Daniel J. Klionsky,et al.  Autophagy fights disease through cellular self-digestion , 2008, Nature.

[3]  J. Dice Chaperone-Mediated Autophagy , 2007, Autophagy.

[4]  A. Cuervo,et al.  Altered dynamics of the lysosomal receptor for chaperone-mediated autophagy with age , 2007, Journal of Cell Science.

[5]  E. Bergamini,et al.  Evidence for Selective Mitochondrial Autophagy and Failure in Aging , 2007, Autophagy.

[6]  A. Cuervo,et al.  Consequences of the selective blockage of chaperone-mediated autophagy. , 2006, Proceedings of the National Academy of Sciences of the United States of America.

[7]  A. Cuervo,et al.  Oxidative stress and autophagy. , 2006, Antioxidants & redox signaling.

[8]  Douglas L. Schmucker,et al.  Age-related changes in liver structure and function: Implications for disease ? , 2005, Experimental Gerontology.

[9]  Ana Maria Cuervo,et al.  Autophagy and Aging: The Importance of Maintaining "Clean" Cells , 2005, Autophagy.

[10]  P. Finn,et al.  Ketone Bodies Stimulate Chaperone-mediated Autophagy* , 2005, Journal of Biological Chemistry.

[11]  Peter T. Lansbury,et al.  Impaired Degradation of Mutant α-Synuclein by Chaperone-Mediated Autophagy , 2004, Science.

[12]  A. Cuervo Autophagy: in sickness and in health. , 2004, Trends in cell biology.

[13]  U. Brunk,et al.  Lipofuscin: mechanisms of age-related accumulation and influence on cell function. , 2002, Free radical biology & medicine.

[14]  A. Cuervo,et al.  Age-related Decline in Chaperone-mediated Autophagy* , 2000, The Journal of Biological Chemistry.

[15]  E. Knecht,et al.  Import of a cytosolic protein into lysosomes by chaperone-mediated autophagy depends on its folding state. , 2000, The Journal of biological chemistry.

[16]  V. Vasiliou,et al.  Zoxazolamine-induced paralysis in two rat substrains: differences in hepatic drug metabolism , 1998, European Journal of Drug Metabolism and Pharmacokinetics.

[17]  T. Koji,et al.  Aging accelerates but life-long dietary restriction suppresses apoptosis-related Fas expression on hepatocytes. , 1997, The American journal of pathology.

[18]  S. R. Terlecky,et al.  An Intralysosomal hsp70 Is Required for a Selective Pathway of Lysosomal Protein Degradation , 1997, The Journal of cell biology.

[19]  A. Cuervo,et al.  A Receptor for the Selective Uptake and Degradation of Proteins by Lysosomes , 1996, Science.

[20]  A. Cuervo,et al.  Degradation of proteasomes by lysosomes in rat liver. , 1995, European journal of biochemistry.

[21]  S. R. Terlecky,et al.  A role for a 70-kilodalton heat shock protein in lysosomal degradation of intracellular proteins. , 1989, Science.

[22]  T. Tanaka,et al.  Aminotransferase activity in the liver of diabetic mice. , 1988, Diabetes research and clinical practice.

[23]  R. Wattiaux,et al.  Isolation of rat liver lysosomes by isopycnic centrifugation in a metrizamide gradient , 1978, The Journal of cell biology.

[24]  Oliver H. Lowry,et al.  Protein measurement with the Folin phenol reagent. , 1951, The Journal of biological chemistry.

[25]  A. Cuervo,et al.  Chaperone-mediated autophagy in aging and disease. , 2006, Current topics in developmental biology.

[26]  Neil D. Rawlings,et al.  Handbook of proteolytic enzymes , 1998 .

[27]  A. Terman The effect of age on formation and elimination of autophagic vacuoles in mouse hepatocytes. , 1995, Gerontology.

[28]  B. Storrie,et al.  Isolation of subcellular organelles. , 1990, Methods in enzymology.

[29]  D. Dearborn,et al.  [50] Protein labeling by reductive alkylation , 1983 .