Mathematical modeling in bone biology: from intracellular signaling to tissue mechanics.

Although conceptual and experimental models are historically well incorporated in bone biology studies, mathematical modeling has been much less-frequently utilized. This review aims to introduce mathematical modeling to readers who are not familiar with the concept underlying this methodology, to outline how mathematical models can help to improve current understanding of bone biology and to discuss examples where mathematical modeling was used to provide new insights into important questions of bone biology.

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