Regulation of translation in eukaryotic systems.

The striking differences between prokaryotes and eukaryotes in cell structure, in the mechanism of initiation of translation, and in the structure of messenger RNAs dictate strikingly different approaches to regulating translation. The first section of this review gives a thumbnail comparison of translational regulation in prokaryotic and eukaryotic systems. The remaining sections expand the discussion of regulatory mechanisms that operate during the initiation phase of protein synthesis in eukaryotes .

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