Studies of d-Tubocurarine Pharmacokinetics in Humans and Dogs

The pharmacokinetics of d-tubocurarine was studied in man during single and multiple administrations of d-tubocurarine, and in dogs during single administrations. The simplest model consistent with our data was a two-compartment open model. The mean half-lives for the two phases in the human studies were 8.9 and 123.8 minutes. For the greyhounds these mean values were 2.8 and 77.4 minutes. The animals did not demonstrate a difference between the arterial and mixed venous concentrations of d-tubocurarine.

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