The NLRP3 inflammasome triggers sterile neuroinflammation and Alzheimer's disease.
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[1] C. Pellegrini,et al. Microbiota-gut-brain axis in health and disease: Is NLRP3 inflammasome at the crossroads of microbiota-gut-brain communications? , 2020, Progress in Neurobiology.
[2] M. Heneka,et al. β-Amyloid Clustering around ASC Fibrils Boosts Its Toxicity in Microglia , 2020, Cell reports.
[3] Y. Hao,et al. New mechanism of neuroinflammation in Alzheimer's disease: The activation of NLRP3 inflammasome mediated by gut microbiota , 2020, Progress in Neuro-Psychopharmacology and Biological Psychiatry.
[4] M. Heneka,et al. Soluble Aβ oligomers and protofibrils induce NLRP3 inflammasome activation in microglia , 2019, Journal of neurochemistry.
[5] L. Buée,et al. NLRP3 inflammasome activation drives tau pathology , 2019, Nature.
[6] K. Schroder,et al. Inflammasome signaling and regulation of interleukin-1 family cytokines , 2019, The Journal of experimental medicine.
[7] M. Heneka,et al. Systemic inflammation impairs microglial Aβ clearance through NLRP3 inflammasome , 2019, The EMBO journal.
[8] C. Day,et al. MCC950 directly targets the NLRP3 ATP-hydrolysis motif for inflammasome inhibition , 2019, Nature Chemical Biology.
[9] J. Ting,et al. The NLRP3 inflammasome: molecular activation and regulation to therapeutics , 2019, Nature Reviews Immunology.
[10] I. Dewachter,et al. Aggregated Tau activates NLRP3–ASC inflammasome exacerbating exogenously seeded and non-exogenously seeded Tau pathology in vivo , 2019, Acta Neuropathologica.
[11] Dan J Stein,et al. Global, regional, and national burden of Alzheimer's disease and other dementias, 1990–2016: a systematic analysis for the Global Burden of Disease Study 2016 , 2019, The Lancet Neurology.
[12] A. Angiolillo,et al. Circulating levels of IL-1 family cytokines and receptors in Alzheimer’s disease: new markers of disease progression? , 2018, Journal of Neuroinflammation.
[13] Zhijian J. Chen,et al. PtdIns4P on Dispersed Trans-Golgi Network Mediates NLRP3 Inflammasome Activation , 2018, Nature.
[14] Daniel R. Caffrey,et al. Inflammasome-derived cytokine IL18 suppresses amyloid-induced seizures in Alzheimer-prone mice , 2018, Proceedings of the National Academy of Sciences.
[15] K. Schroder,et al. Interleukin-1β Maturation Triggers Its Relocation to the Plasma Membrane for Gasdermin-D-Dependent and -Independent Secretion. , 2018, Cell reports.
[16] B. Delatour,et al. New role of P2X7 receptor in an Alzheimer’s disease mouse model , 2018, Molecular Psychiatry.
[17] L. Facci,et al. Serum amyloid A primes microglia for ATP-dependent interleukin-1β release , 2018, Journal of Neuroinflammation.
[18] Justyna O. Ekert,et al. TNF alpha inhibitors in Alzheimer's disease: A systematic review , 2018, International journal of geriatric psychiatry.
[19] M. Surette,et al. Age-Associated Microbial Dysbiosis Promotes Intestinal Permeability, Systemic Inflammation, and Macrophage Dysfunction , 2018, Cell host & microbe.
[20] D. Gibson,et al. Age and Age-Related Diseases: Role of Inflammation Triggers and Cytokines , 2018, Front. Immunol..
[21] Jelena S. Bezbradica,et al. Caspase-1 self-cleavage is an intrinsic mechanism to terminate inflammasome activity , 2018, The Journal of experimental medicine.
[22] L. Hooper,et al. Dysbiosis-Associated Change in Host Metabolism Generates Lactate to Support Salmonella Growth. , 2018, Cell host & microbe.
[23] M. Heneka,et al. Microglia-derived ASC specks cross-seed amyloid-β in Alzheimer’s disease , 2017, Nature.
[24] L. Facci,et al. Expression and Differential Responsiveness of Central Nervous System Glial Cell Populations to the Acute Phase Protein Serum Amyloid A , 2017, Scientific Reports.
[25] G. Frisoni,et al. Association of brain amyloidosis with pro-inflammatory gut bacterial taxa and peripheral inflammation markers in cognitively impaired elderly , 2017, Neurobiology of Aging.
[26] Jelena S. Bezbradica,et al. Sterile signals generate weaker and delayed macrophage NLRP3 inflammasome responses relative to microbial signals , 2016, Cellular & Molecular Immunology.
[27] G. Núñez,et al. Nek7 is an essential mediator of NLRP3 activation downstream of potassium efflux , 2016, Nature.
[28] D. Baker,et al. Cellular senescence in aging and age-related disease: from mechanisms to therapy , 2015, Nature Medicine.
[29] T. Cai,et al. Cleavage of GSDMD by inflammatory caspases determines pyroptotic cell death , 2015, Nature.
[30] Haitao Guo,et al. Inflammasomes: mechanism of action, role in disease, and therapeutics , 2015, Nature Medicine.
[31] O. Garaschuk,et al. Neuroinflammation in Alzheimer's disease , 2015, The Lancet Neurology.
[32] M. Heneka,et al. Innate immunity in Alzheimer's disease , 2015, Nature Immunology.
[33] Michael T. Heneka,et al. Innate immune activation in neurodegenerative disease , 2014, Nature Reviews Immunology.
[34] Vishva M. Dixit,et al. Mechanisms and Functions of Inflammasomes , 2014, Cell.
[35] Katherine A. Fitzgerald,et al. Unified Polymerization Mechanism for the Assembly of ASC-Dependent Inflammasomes , 2014, Cell.
[36] Zhijian J. Chen,et al. Prion-like Polymerization Underlies Signal Transduction in Antiviral Immune Defense and Inflammasome Activation , 2014, Cell.
[37] Abbas Ali Mahdi,et al. Therapeutics of Alzheimer's disease: Past, present and future , 2014, Neuropharmacology.
[38] D. Ingram,et al. Canonical Nlrp3 inflammasome links systemic low-grade inflammation to functional decline in aging. , 2013, Cell metabolism.
[39] Haitao Wen,et al. Mechanisms of NOD-like receptor-associated inflammasome activation. , 2013, Immunity.
[40] L. Tan,et al. The NLRP3 Inflammasome in Alzheimer’s Disease , 2013, Molecular Neurobiology.
[41] F. Heppner,et al. Functional Impairment of Microglia Coincides with Beta-Amyloid Deposition in Mice with Alzheimer-Like Pathology , 2013, PloS one.
[42] M. Heneka,et al. NLRP3 is activated in Alzheimer´s disease and contributes to pathology in APP/PS1 mice , 2012, Nature.
[43] Vishva M Dixit,et al. Inflammasomes and their roles in health and disease. , 2012, Annual review of cell and developmental biology.
[44] Richard A. Flavell,et al. Inflammasomes in health and disease , 2012, Nature.
[45] Debashis Sahoo,et al. Human bone marrow hematopoietic stem cells are increased in frequency and myeloid-biased with age , 2011, Proceedings of the National Academy of Sciences.
[46] E. Latz,et al. Intracellular sensing of microbes and danger signals by the inflammasomes , 2011, Immunological reviews.
[47] J. Tschopp,et al. A role for mitochondria in NLRP3 inflammasome activation , 2011, Nature.
[48] Lian-tang Wang,et al. Endogenous toll-like receptor ligands and their biological significance , 2010, Journal of cellular and molecular medicine.
[49] C. Bryant,et al. Molecular mechanisms involved in inflammasome activation. , 2009, Trends in cell biology.
[50] J. Campisi,et al. Persistent DNA damage signaling triggers senescence-associated inflammatory cytokine secretion , 2009, Nature Cell Biology.
[51] F. Martinon,et al. The inflammasomes: guardians of the body. , 2009, Annual review of immunology.
[52] Weiming Xia,et al. A specific enzyme-linked immunosorbent assay for measuring beta-amyloid protein oligomers in human plasma and brain tissue of patients with Alzheimer disease. , 2009, Archives of neurology.
[53] David L. Brody,et al. Amyloid-β Dynamics Correlate with Neurological Status in the Injured Human Brain , 2008, Science.
[54] M. Albert,et al. Distinct pools of beta-amyloid in Alzheimer disease-affected brain: a clinicopathologic study. , 2008, Archives of neurology.
[55] K. Moore,et al. The NALP3 inflammasome is involved in the innate immune response to amyloid-β , 2008, Nature Immunology.
[56] N. Weng. Telomere and adaptive immunity , 2008, Mechanisms of Ageing and Development.
[57] David Miller,et al. Critical Role for Cryopyrin/Nalp3 in Activation of Caspase-1 in Response to Viral Infection and Double-stranded RNA*> , 2006, Journal of Biological Chemistry.
[58] V. Dixit,et al. Cryopyrin activates the inflammasome in response to toxins and ATP , 2006, Nature.
[59] J. Julien,et al. Bone Marrow-Derived Microglia Play a Critical Role in Restricting Senile Plaque Formation in Alzheimer's Disease , 2006, Neuron.
[60] F. Martinon,et al. Identification of Bacterial Muramyl Dipeptide as Activator of the NALP3/Cryopyrin Inflammasome , 2004, Current Biology.
[61] F. Martinon,et al. Inflammatory Caspases Linking an Intracellular Innate Immune System to Autoinflammatory Diseases , 2004, Cell.
[62] F. Martinon,et al. NALP3 forms an IL-1beta-processing inflammasome with increased activity in Muckle-Wells autoinflammatory disorder. , 2004, Immunity.
[63] W. Griffin,et al. Increased interleukin-1beta converting enzyme expression and activity in Alzheimer disease. , 1998, Journal of neuropathology and experimental neurology.
[64] C. Gabel,et al. Interleukin-1 beta maturation and release in response to ATP and nigericin. Evidence that potassium depletion mediated by these agents is a necessary and common feature of their activity. , 1994, The Journal of biological chemistry.
[65] G. Perry,et al. Microglia are associated with the extracellular neurofibrillary tangles of alzheimer disease , 1991, Brain Research.
[66] Jun-tao Guo,et al. Apolipoprotein Serum Amyloid A in Alzheimer's Disease. , 1999, Journal of Alzheimer's disease : JAD.