Pharmacological evaluation of cimetidine, a new histamine H2-receptor antagonist, in healthy man.

Cimetidine, a new H2-receptor antagonist, was safely administered to eighteen healthy man by the intravenous, intraduodenal or oral route. 2 When gastric secretion was maximally stimulated by either histamine or pentagastrin, the simultaneous administration of cimetidine produced marked inhibition of both acid and pepsin secretion. 3 Cimetidine was well absorbed by mouth and had a blood half-life of 2 hours. 4 Cimetidine was rapidly excreted via the kidneys and about 70% of the excreted material was unchanged drug. 5 Clinical evaluation of cimetidine in patients with peptic ulceration is recommended.

[1]  Clark Cg,et al.  Clinical experience with metiamide. , 1976 .

[2]  R. Pounder,et al.  Relief of duodenal ulcer sysmptons by oral metiamide. , 1975, British medical journal.

[3]  J. Walsh,et al.  The effect of an H2-receptor antagonist on food-stimulated acid secretion, serum gastrin, and gastric emptying in patients with duodenal ulcers. Comparison with an anticholinergic drug. , 1975, The Journal of clinical investigation.

[4]  Graham J. Durant,et al.  Cimetidine—A Non-Thiourea H2-Receptor Antagonist , 1975 .

[5]  D. Shearman,et al.  NEUTROPENIA ASSOCIATED WITH METIAMIDE , 1975, The Lancet.

[6]  E. L. Blair,et al.  Metiamide in the Zollinger-Ellison syndrome , 1975, The Lancet.

[7]  D. Carter,et al.  Effect of Histamine H2-Receptor Blockade on Vagally Induced Gastric Secretion in Man , 1974, British medical journal.

[8]  R. Sturdevant,et al.  Metiamide, an H2-receptor blocker, as inhibitor of basal and meal-stimulated gastric acid secretion in patients with duodenal ulcer. , 1974, The New England journal of medicine.

[9]  B. Thjódleifsson,et al.  Gastric Response to Metiamide , 1974, British medical journal.

[10]  J. Rehfeld,et al.  Effect of metiamide, a histamine H2-receptor antagonist, on mucosal blood flow and serum gastrin level. , 1974, Gastroenterology.

[11]  J. Williams,et al.  Inhibition of nocturnal acid secretion in duodenal ulcer by one oral dose of metiamide. , 1974, Lancet.

[12]  W. Ealding,et al.  Inhibition of gastric secretion in man by metiamide: a new, orally active histamine H 2 -receptor antagonist. , 1973, Gut.

[13]  J. Black,et al.  Clinical experience with metiamide. , 1976, Federation proceedings.

[14]  S. Bonfils,et al.  [The automatic determination of proteolytic activity of gastric juice]. , 1968, Biologie et gastro-enterologie.