Proteinuria in Children with Febrile Illnesses

Transient proteinuria in the absence of underlying renal disease was detected in 11 of 198 children (5·6%) admitted to hospital with an acute febrile illness. Proteinuria was noted only in children whose fever was higher than 38·4 °C. Selectivity studies on the protein excreted showed patterns ranging from poorly to highly selective. Initial screening for proteinuria using a dipstick method revealed a high incidence of false positives, of which only about 30% could be confirmed by the sulphosalicylic acid method. The pathophysiology of transient proteinuria in febrile patients is not understood; a number of mechanisms are probably involved. Since fever was the only detected feature common to each of the patients with proteinuria, it seems unlikely that the specific aetiology of the fever is a factor of importance in the pathogenesis of the proteinuria.

[1]  K. Gillis,et al.  Proteinuria , 1985, Springer US.

[2]  E. Becker.  Proteinuria in renal disease. , 1970, Bulletin of the New York Academy of Medicine.

[3]  J. Blainey,et al.  Urinary lysozyme, ribonuclease, and low-molecular-weight protein in renal disease. , 1968, Lancet.

[4]  W. Macbeth,et al.  Effect of abdominal operation upon protein excretion in man. , 1968, Lancet.

[5]  J. Poortmans,et al.  Quantitative immunological determination of 12 plasma proteins excreted in human urine collected before and after exercise. , 1968, The Journal of clinical investigation.

[6]  G. E. Burch,et al.  Viral nephritis. , 1968, American Heart Journal.

[7]  M. M. Jensen.  Viruses and kidney disease. , 1967, The American journal of medicine.

[8]  M. Randolph,et al.  Proteinuria. A six-year study of normal infants, preschool, and school-age populations previously screened for urinary tract disease. , 1967, American journal of diseases of children.

[9]  H. Keen,et al.  Evaluation of clinical methods for detecting proteinuria. , 1967, Lancet.

[10]  J. Robson,et al.  A simple method for determining selectivity of proteinuria. , 1967, The Lancet.

[11]  G. Arneil,et al.  Long Term Results of Intensive Steroid Therapy of Childhood Nephrosis , 1967 .

[12]  Management of the nephrotic syndrome due to primary renal disease. , 1967, Canadian Medical Association journal.

[13]  J. Soothill,et al.  Proteinuria in multiple myeloma. , 1966, Clinical science.

[14]  Detection of proteinuria. , 1966, The Medical letter on drugs and therapeutics.

[15]  R. White,et al.  SELECTIVITY OF PROTEINURIA IN CHILDREN WITH THE NEPHROTIC SYNDROME. , 1965, Lancet.

[16]  J. Cameron,et al.  SELECTIVITY OF PROTEIN EXCRETION IN PATIENTS WITH THE NEPHROTIC SYNDROME. , 1964, The Journal of clinical investigation.

[17]  H. McFarlane.  A SIMPLE RAPID METHOD OF CONCENTRATING URINE FOR PROTEIN ELECTROPHORESIS. , 1964, Clinica chimica acta; international journal of clinical chemistry.

[18]  J. Soothill.  Studies on proteinuria with special reference to immunochemically determined differential protein clearances. , 1962, Guy's Hospital reports.

[19]  Soothill Jf,et al.  The proteins of postural and exercise proteinuria. , 1961 .

[20]  Soothill Jf,et al.  Serum proteins in normal urine. , 1961 .

[21]  I. Berggård.  Studies on the plasma proteins in normal human urine , 1961 .

[22]  J. Soothill,et al.  Serum proteins in normal urine. , 1961, Clinical science.

[23]  J. Soothill,et al.  The proteins of postural and exercise proteinuria. , 1961, Clinical science.

[24]  R. Slater,et al.  Studies on human proteinuria. 1. the mechanism of postural proteinuria. , 1960, Pediatrics.

[25]  V. Pollak,et al.  Asymptomatic persistent proteinuria: studies by renal biopsies. , 1958, Guy's Hospital reports.

[26]  G. Schreiner.  The differential diagnosis of acute and chronic glomerulonephritis. , 1957, Journal of chronic diseases.

[27]  Sellers Al.  The mechanism and significance of protein excretion by the normal kidney. , 1956 .

[28]  R. E. Johnson,et al.  The effects of diet on renal function in healthy men. , 1956, The American journal of clinical nutrition.

[29]  A. Sellers.  The mechanism and significance of protein excretion by the normal kidney. , 1956, A.M.A. archives of internal medicine.

[30]  C. Gronbeck,et al.  Benign and pathologic albuminuria; a study of 600 hospitalized cases. , 1952, Annals of internal medicine.

[31]  D. Rigas,et al.  The amount and nature of urinary proteins in normal human subjects. , 1951, The Journal of clinical investigation.

[32]  A. Gornall,et al.  Determination of serum proteins by means of the biuret reaction. , 1949, The Journal of biological chemistry.

[33]  Winkler Jl.  Fatal hypoglycaemia in a diabetic. , 1948 .

[34]  J. M. Looney,et al.  THE DETERMINATION OF SPINAL FLUID PROTEIN WITH THE PHOTOELECTRIC COLORIMETER , 1939 .

[35]  J. W. Welty.  FEBRILE ALBUMINURIA , 1937 .

[36]  I. Starr.  THE PRODUCTION OF ALBUMINURIA BY RENAL VASOCONSTRICTION IN ANIMALS AND IN MAN , 1925, The Journal of experimental medicine.

[37]  C. Gerhardt.  Ueber die Eiweisstoffe des Harns , 1869 .