RB and cyclin dependent kinase pathways: defining a distinction between RB and p16 loss in lung cancer
暂无分享,去创建一个
[1] J. Harbour,et al. The Rb/E2F pathway: expanding roles and emerging paradigms. , 2000, Genes & development.
[2] Rene H Medema,et al. Rescue of Cyclin D1 Deficiency by Knockin Cyclin E , 1999, Cell.
[3] Phang-lang Chen,et al. Phosphorylation of the retinoblastoma gene product is modulated during the cell cycle and cellular differentiation , 1989, Cell.
[4] B. Ponder,et al. Molecular Genetics of Cancer , 1992, Nature Medicine.
[5] A. Bradley,et al. Mice deficient for Rb are nonviable and show defects in neurogenesis and haematopoiesis , 1992, Nature.
[6] J. Herman,et al. In situ detection of the hypermethylation-induced inactivation of the p16 gene as an early event in oncogenesis. , 1999, Proceedings of the National Academy of Sciences of the United States of America.
[7] J. Minna,et al. Multiple clonal abnormalities in the bronchial epithelium of patients with lung cancer. , 1999, Journal of the National Cancer Institute.
[8] Y. Geng,et al. Specific protection against breast cancers by cyclin D1 ablation , 2001, Nature.
[9] Molecular pathogenesis of lung cancer. , 2002 .
[10] Rosalie C Sears,et al. Signaling Networks That Link Cell Proliferation and Cell Fate* , 2002, The Journal of Biological Chemistry.
[11] Peggy J. Farnham,et al. Expression cloning of a cDNA encoding a retinoblastoma-binding protein with E2F-like properties , 1992, Cell.
[12] L. Donehower,et al. Mice deficient in both p53 and Rb develop tumors primarily of endocrine origin. , 1995, Cancer research.
[13] R. Weinberg,et al. Effects of an Rb mutation in the mouse , 1992, Nature.
[14] T. Jacks,et al. Cooperative tumorigenic effects of germline mutations in Rb and p53 , 1994, Nature Genetics.
[15] J. Decaprio,et al. The J Domain of Simian Virus 40 Large T Antigen Is Required To Functionally Inactivate RB Family Proteins , 1998, Molecular and Cellular Biology.
[16] G. Hannon,et al. A new regulatory motif in cell-cycle control causing specific inhibition of cyclin D/CDK4 , 1993, Nature.
[17] F. Hirsch,et al. Epidermal growth factor receptor family in lung cancer and premalignancy. , 2002, Seminars in oncology.
[18] J. Yokota,et al. Identification and characterization of families with aggregation of lung cancer. , 1998, Japanese journal of clinical oncology.
[19] Chun-Ming Huang,et al. SV40 large T antigen binds preferentially to an underphosphorylated member of the retinoblastoma susceptibility gene product family , 1989, Cell.
[20] P. K. Davis,et al. Vivo Cyclin-dependent Kinase Complexes in 1 Tumor Suppressor Protein by G Differential Regulation of Retinoblastoma , 2001 .
[21] Molecular genetics of cancer. , 1992 .
[22] S. Salama,et al. Combinatorial roles for pRB, p107, and p130 in E2F-mediated cell cycle control. , 2000, Proceedings of the National Academy of Sciences of the United States of America.
[23] A. de Leiva,et al. Ras Oncogene Mutations in Thyroid Tumors: Polymerase Chain Reaction‐Restriction‐Fragment‐Length Polymorphism Analysis from Paraffin‐Embedded Tissues , 1996, Diagnostic molecular pathology : the American journal of surgical pathology, part B.
[24] W. Kaelin,et al. Role of the retinoblastoma protein in the pathogenesis of human cancer. , 1997, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.
[25] M. Barbacid,et al. Cyclin D-dependent kinases, INK4 inhibitors and cancer. , 2002, Biochimica et biophysica acta.
[26] S. Steinberg,et al. Differential inactivation of CDKN2 and Rb protein in non-small-cell and small-cell lung cancer cell lines. , 1995, Journal of the National Cancer Institute.
[27] James M. Roberts,et al. The p21Cip1 and p27Kip1 CDK ‘inhibitors’ are essential activators of cyclin D‐dependent kinases in murine fibroblasts , 1999, The EMBO journal.
[28] F. Marincola,et al. Sequential 5-Aza-2′-deoxycytidine-Depsipeptide FR901228 Treatment Induces Apoptosis Preferentially in Cancer Cells and Facilitates Their Recognition by Cytolytic T Lymphocytes Specific for NY-ESO-1 , 2001, Journal of immunotherapy.
[29] F. Kaye,et al. RET cooperates with RB/p53 inactivation in a somatic multi-step model for murine thyroid cancer , 1998, Oncogene.
[30] Wen-Hwa Lee,et al. Expression and amplification of the N-myc gene in primary retinoblastoma , 1984, Nature.
[31] David M. Livingston,et al. The product of the retinoblastoma susceptibility gene has properties of a cell cycle regulatory element , 1989, Cell.
[32] J. Bartek,et al. Pathways governing G1/S transition and their response to DNA damage , 2001, FEBS letters.
[33] J. Herman,et al. 5′ CpG island methylation is associated with transcriptional silencing of the tumour suppressor p16/CDKN2/MTS1 in human cancers , 1995, Nature Medicine.
[34] Wen-Hwa Lee,et al. The retinoblastoma susceptibility gene encodes a nuclear phosphoprotein associated with DNA binding activity , 1987, Nature.
[35] Steven F. Dowdy,et al. Regulation of G1 cell-cycle progression by oncogenes and tumor suppressor genes , 2002 .
[36] M. Tucker,et al. Hereditary retinoblastoma and risk of lung cancer. , 2000, Journal of the National Cancer Institute.
[37] D. Shibata,et al. Most human carcinomas of the exocrine pancreas contain mutant c-K-ras genes , 1988, Cell.
[38] E. Sausville,et al. Preclinical and clinical development of cyclin-dependent kinase modulators. , 2000, Journal of the National Cancer Institute.
[39] G. G. Stokes. "J." , 1890, The New Yale Book of Quotations.
[40] F. Hirsch,et al. HER2/neu expression in malignant lung tumors. , 2002, Seminars in oncology.
[41] G. Draper,et al. Non-ocular cancer in relatives of retinoblastoma patients. , 1989, British Journal of Cancer.
[42] Jonathan A. Cooper,et al. RB and the cell cycle: Entrance or exit? , 1989, Cell.
[43] J. Herman,et al. A bird's eye view of global methylation , 2000, Nature Genetics.
[44] R. Makuch,et al. myc family DNA amplification in small cell lung cancer patients' tumors and corresponding cell lines. , 1988, Cancer research.
[45] F. Kaye,et al. A single amino acid substitution results in a retinoblastoma protein defective in phosphorylation and oncoprotein binding. , 1990, Proceedings of the National Academy of Sciences of the United States of America.
[46] J. Minna,et al. Origin of human small cell lung cancer. , 1985, Science.
[47] T. Jacks,et al. The retinoblastoma gene family in differentiation and development , 1999, Oncogene.
[48] R. Weinberg,et al. The retinoblastoma protein and cell cycle control , 1995, Cell.
[49] J. Minna,et al. Abnormalities in structure and expression of the human retinoblastoma gene in SCLC. , 1988, Science.
[50] James M. Roberts,et al. CDK inhibitors: positive and negative regulators of G1-phase progression. , 1999, Genes & development.
[51] C. Eng,et al. Mortality From Second Tumors Among Long-Term Survivors of Retinoblastoma , 1993 .
[52] C. D. Edwards,et al. Reciprocal Rb inactivation and p16INK4 expression in primary lung cancers and cell lines. , 1995, Cancer research.
[53] S. Schröder,et al. Absence of H- and K-ras oncogene mutations in sporadic medullary thyroid carcinoma. , 2012, Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association.
[54] J. Yokota,et al. How many tumor suppressor genes are involved in human lung carcinogenesis? , 1999, Carcinogenesis.
[55] F. Kaye,et al. CDKN2 in HPV‐positive and HPV‐negative cervical‐carcinoma cell lines , 1995, International journal of cancer.
[56] F. Kaye,et al. Protein expression of the RB-related gene family and SV40 large T antigen in mesothelioma and lung cancer , 2000, Oncogene.
[57] R. Weinberg,et al. Physical interaction of the retinoblastoma protein with human D cyclins , 1993, Cell.
[58] D. Sidransky,et al. Rates of p16 (MTS1) mutations in primary tumors with 9p loss. , 1994, Science.
[59] F. Kaye,et al. Identification of cellular proteins that can interact specifically with the T/ElA-binding region of the retinoblastoma gene product , 1991, Cell.
[60] N. Tommerup,et al. Loss of the retinoblastoma protein-related p130 protein in small cell lung carcinoma. , 1997, Proceedings of the National Academy of Sciences of the United States of America.
[61] A. El‐Naggar,et al. Differential retinoblastoma protein expression in neuroendocrine tumors of the lung. Potential diagnostic implications. , 1997, The American journal of pathology.
[62] G. Peters,et al. Lack of cyclin D‐Cdk complexes in Rb‐negative cells correlates with high levels of p16INK4/MTS1 tumour suppressor gene product. , 1995, The EMBO journal.
[63] N. Dyson,et al. Retinoblastoma protein partners. , 2001, Advances in cancer research.
[64] Peter A. Jones,et al. P16 gene in uncultured tumours , 1994, Nature.
[65] R. Momparler,et al. Potential of 5-aza-2'-deoxycytidine (Decitabine) a potent inhibitor of DNA methylation for therapy of advanced non-small cell lung cancer. , 2001, Lung cancer.
[66] Stephen H. Friend,et al. A human DNA segment with properties of the gene that predisposes to retinoblastoma and osteosarcoma , 1986, Nature.
[67] M. Skolnick,et al. A cell cycle regulator potentially involved in genesis of many tumor types. , 1994, Science.
[68] J. Easton,et al. Disruption of the cyclin D/cyclin-dependent kinase/INK4/retinoblastoma protein regulatory pathway in human neuroblastoma. , 1998, Cancer research.
[69] J. Battey,et al. Human small-cell lung cancers show amplification and expression of the N-myc gene. , 1986, Proceedings of the National Academy of Sciences of the United States of America.
[70] P. Adams. Regulation of the retinoblastoma tumor suppressor protein by cyclin/cdks. , 2001, Biochimica et biophysica acta.
[71] R. Weinberg,et al. Frequent inactivation of the retinoblastoma anti-oncogene is restricted to a subset of human tumor cells. , 1990, Proceedings of the National Academy of Sciences of the United States of America.
[72] A. Gazdar,et al. K-ras mutations are a relatively late event in the pathogenesis of lung carcinomas. , 1994, Cancer research.
[73] D. Abramson,et al. Third (fourth and fifth) nonocular tumors in survivors of retinoblastoma. , 2001, Ophthalmology.
[74] M Terada,et al. Loss of heterozygosity on chromosomes 3, 13, and 17 in small-cell carcinoma and on chromosome 3 in adenocarcinoma of the lung. , 1987, Proceedings of the National Academy of Sciences of the United States of America.
[75] S. Baylin,et al. v-rasH induces non-small cell phenotype, with associated growth factors and receptors, in a small cell lung cancer cell line. , 1990, The Journal of clinical investigation.
[76] Charles J. Sherr,et al. The INK4a/ARF network in tumour suppression , 2001, Nature Reviews Molecular Cell Biology.
[77] Liang Zhu,et al. Requirement of Cyclin E-Cdk2 Inhibition in p16INK4a-Mediated Growth Suppression , 1998, Molecular and Cellular Biology.
[78] B. Dynlacht,et al. Tumour-derived p16 alleles encoding proteins defective in cell-cycle inhibition , 1995, Nature.