RELATIONSHIP BETWEEN THE ENVIRONMENTAL ENDOCRINE DISRUPTOR BISPHENOL A AND DYSLIPIDEMIA: A FIVE-YEAR PROSPECTIVE STUDY.

Objective: To investigate whether serum Bisphenol A (BPA) concentration is related to the occurrence of dyslipidemia. Methods: A total of 574 adults were enrolled at baseline and followed up for 5 years. Concentrations of serum BPA, triglycerides (TGs), low-density lipoprotein cholesterol (LDL-c) and high-density lipoprotein cholesterol (HDL-c) were measured. Dyslipidemia was defined as the existence of one or more following conditions: high-LDL-cholesterolemia (LDL-c≥140 mg/dL), hypertriglyceridemia (TGs≥150 mg/dL), or low-HDL-cholesterolemia (HDL-c<40 mg/dL). Participants were stratified into tertiles according to low, median and high baseline serum BPA levels. Multivariable linear and logistic regression models were used. Data from baseline and follow-up were used for cross-sectional and longitudinal analyses, respectively. Results: In the cross-sectional analysis, compared to subjects in low BPA tertile, these in high BPA tertile showed a higher level of LDL-c (108.1±24.4 vs. 119.5±26.9 mg/dL, P<0.05) and a lower level of HDL-c (46.2±11.7 vs. 39.5±7.5 mg/dL, P<0.05). In multivariable linear regression models, Z-transformed BPA was positively associated with LDL-c (β= 0.13, P= 0.002) and negatively associated with HDL-c (β= -0.28, P<0.001). After cross-sectionally adjusting for confounders, subjects in higher BPA exposure was associated with a higher prevalence of low-HDL-cholesterolemia. Longitudinally, in subjects without low-HDL-cholesterolemia at baseline, each standard deviation (per-SD) increment in baseline BPA was associated with a higher incidence of low-HDL-cholesterolemia after confounders adjustment [OR (95% CI) 2.76 (95% CI 1.21, 6.29)] . Conclusion: Cross-sectionally, higher BPA exposure is associated with a higher prevalence of low-HDL-cholesterolemia. Longitudinally, baseline BPA is an independent predictor of the 5-year incidence of low-HDL-cholesterolemia.