EpiExploreR: A Shiny Web Application for the Analysis of Animal Disease Data

Emerging and re-emerging infectious diseases are a significant public and animal health threat. In some zoonosis, the early detection of virus spread in animals is a crucial early warning for humans. The analyses of animal surveillance data are therefore of paramount importance for public health authorities to identify the appropriate control measure and intervention strategies in case of epidemics. The interaction among host, vectors, pathogen and environment require the analysis of more complex and diverse data coming from different sources. There is a wide range of spatiotemporal methods that can be applied as a surveillance tool for cluster detection, identification of risk areas and risk factors and disease transmission pattern evaluation. However, despite the growing effort, most of the recent integrated applications still lack of managing simultaneously different datasets and at the same time making available an analytical tool for a complete epidemiological assessment. In this paper, we present EpiExploreR, a user-friendly, flexible, R-Shiny web application. EpiExploreR provides tools integrating common approaches to analyze spatiotemporal data on animal diseases in Italy, including notified outbreaks, surveillance of vectors, animal movements data and remotely sensed data. Data exploration and analysis results are displayed through an interactive map, tables and graphs. EpiExploreR is addressed to scientists and researchers, including public and animal health professionals wishing to test hypotheses and explore data on surveillance activities.

[1]  Andre Charlett,et al.  An Improved Algorithm for Outbreak Detection in Multiple Surveillance Systems , 2013, Statistics in medicine.

[2]  M. Kulldorff,et al.  A Space–Time Permutation Scan Statistic for Disease Outbreak Detection , 2005, PLoS medicine.

[3]  K. Paaijmans,et al.  The Effect of Temperature on Anopheles Mosquito Population Dynamics and the Potential for Malaria Transmission , 2013, PloS one.

[4]  Lara Savini,et al.  Network-based assessment of the vulnerability of Italian regions to bovine brucellosis , 2018, bioRxiv.

[5]  Ken Kleinman,et al.  Tools, Classes, and Methods for Interfacing with SaTScanStand-Alone Software , 2015 .

[6]  Martina Morris,et al.  Tools for Temporal Social Network Analysis , 2015 .

[7]  Roger Bivand,et al.  Bindings for the Geospatial Data Abstraction Library , 2015 .

[8]  C. L. Mallows NON-NULL RANKING MODELS. I , 1957 .

[9]  함일한,et al.  Surveillance , 1996 .

[10]  E. Buliva,et al.  Emerging and Reemerging Diseases in the World Health Organization (WHO) Eastern Mediterranean Region—Progress, Challenges, and WHO Initiatives , 2017, Front. Public Health.

[11]  M. Kulldorff,et al.  International Journal of Health Geographics Open Access a Scan Statistic for Continuous Data Based on the Normal Probability Model , 2022 .

[12]  Guangchuang Yu Emoji and Font Awesome in Graphics [R package emojifont version 0.5.3] , 2019 .

[13]  E. Pebesma,et al.  Classes and Methods for Spatial Data , 2015 .

[14]  Hadley Wickham,et al.  Spatial Visualization with ggplot2 , 2016 .

[15]  Alessandro Vespignani,et al.  Epidemic spreading in scale-free networks. , 2000, Physical review letters.

[16]  Benoit Thieurmel,et al.  Network Visualization using 'vis.js' Library , 2015 .

[17]  Robert J. Hijmans,et al.  Geographic Data Analysis and Modeling , 2015 .

[18]  F. Natale,et al.  Network analysis of Italian cattle trade patterns and evaluation of risks for potential disease spread. , 2009, Preventive Veterinary Medicine.

[19]  Michael Höhle,et al.  The R-Package 'surveillance' , 2005 .

[20]  C Dubé,et al.  Introduction to network analysis and its implications for animal disease modelling. , 2011, Revue scientifique et technique.

[21]  K. Shadan,et al.  Available online: , 2012 .

[22]  H. Wickham,et al.  A Grammar of Data Manipulation , 2015 .

[23]  Kohske Takahashi,et al.  Create Elegant Data Visualisations Using the Grammar of Graphics [R package ggplot2 version 3.3.2] , 2020 .

[24]  H. Fry,et al.  Spatial methods for infectious disease outbreak investigations: systematic literature review. , 2015, Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin.

[25]  Yihui Xie,et al.  Create Interactive Web Maps with the JavaScript 'Leaflet'Library , 2015 .

[26]  Enzo Martoglio Build Powerful Pivot Tables and Dynamically Slice & Dice yourData , 2015 .

[27]  Benjamin M. Althouse,et al.  Internet-based biosurveillance methods for vector-borne diseases: Are they novel public health tools or just novelties? , 2017, PLoS neglected tropical diseases.

[28]  F. Rubel,et al.  Explaining Usutu virus dynamics in Austria: model development and calibration. , 2008, Preventive veterinary medicine.

[29]  M. Gilbert,et al.  Environmental heterogeneity and variations in the velocity of bluetongue virus spread in six European epidemics. , 2018, Preventive veterinary medicine.

[30]  M. Craft,et al.  Network Models: An Underutilized Tool in Wildlife Epidemiology? , 2011, Interdisciplinary perspectives on infectious diseases.

[31]  Stefan Widgren,et al.  EpiContactTrace: an R-package for contact tracing during livestock disease outbreaks and for risk-based surveillance , 2014, BMC Veterinary Research.

[32]  Scott Chamberlain,et al.  Create Interactive Web Graphics via 'plotly.js' [R package plotly version 4.9.2.1] , 2020 .

[33]  James C. Kile,et al.  Zoonotic Disease Programs for Enhancing Global Health Security , 2017, Emerging infectious diseases.

[34]  Petra Dickmann,et al.  Drivers of earlier infectious disease outbreak detection: a systematic literature review. , 2016, International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases.

[35]  Inkyung Jung,et al.  A spatial scan statistic for ordinal data , 2007, Statistics in medicine.

[36]  M Kulldorff,et al.  Spatial disease clusters: detection and inference. , 1995, Statistics in medicine.

[37]  A. Giovannini,et al.  Development of a forecasting model for brucellosis spreading in the Italian cattle trade network aimed to prioritise the field interventions , 2017, PloS one.

[38]  Landon Fridman Detwiler,et al.  Visualization and analytics tools for infectious disease epidemiology: A systematic review , 2014, J. Biomed. Informatics.

[39]  E. Etter,et al.  Epidemiological surveillance methods for vector-borne diseases. , 2015, Revue scientifique et technique.

[40]  Anil K. Jain Data clustering: 50 years beyond K-means , 2008, Pattern Recognit. Lett..

[41]  Nick Andrews,et al.  A Statistical Algorithm for the Early Detection of Outbreaks of Infectious Disease , 1996 .

[42]  Eirini Christaki New technologies in predicting, preventing and controlling emerging infectious diseases , 2015, Virulence.

[43]  L. Bonizzi,et al.  Emerging Zoonoses: the "One Health Approach" , 2012, Safety and Health at Work.

[44]  Petra Muellner,et al.  epidemix-An interactive multi-model application for teaching and visualizing infectious disease transmission. , 2017, Epidemics.

[45]  C. Stefano,et al.  Reoccurrence of West Nile Virus Disease in Humans and Successive Entomological Investigation in Sardinia, Italy, 2017 , 2018 .

[46]  Pemetaan Jumlah Balita,et al.  Spatial Scan Statistic , 2014, Encyclopedia of Social Network Analysis and Mining.

[47]  Paula Moraga,et al.  SpatialEpiApp: A Shiny web application for the analysis of spatial and spatio-temporal disease data. , 2017, Spatial and spatio-temporal epidemiology.

[48]  C. Pipper,et al.  [''R"--project for statistical computing]. , 2008, Ugeskrift for laeger.

[49]  Philipp Hövel,et al.  Disease Spread through Animal Movements: A Static and Temporal Network Analysis of Pig Trade in Germany , 2016, PloS one.

[50]  Samuel Soubeyrand,et al.  OutbreakTools: A new platform for disease outbreak analysis using the R software , 2014, Epidemics.

[51]  David Welch,et al.  epinet: An R Package to Analyze Epidemics Spread across Contact Networks , 2018 .

[52]  David L. Wheeler,et al.  GenBank , 2015, Nucleic Acids Res..

[53]  C. Ducrot,et al.  Estimating front-wave velocity of infectious diseases: a simple, efficient method applied to bluetongue , 2011, Veterinary research.

[54]  Jihye Choi,et al.  Web-based infectious disease surveillance systems and public health perspectives: a systematic review , 2016, BMC Public Health.

[55]  Carter T. Butts Classes for Relational Data , 2015 .

[56]  Colin W. Rundel,et al.  Interface to Geometry Engine - Open Source (GEOS) , 2015 .

[57]  Jj Allaire,et al.  HTML Widgets for R , 2015 .

[58]  Li Wang,et al.  Forward reachable sets: Analytically derived properties of connected components for dynamic networks , 2016, Network Science.

[59]  Yihui Xie,et al.  A Wrapper of the JavaScript Library 'DataTables' , 2015 .

[60]  Dirk U Pfeiffer,et al.  Spatial and temporal epidemiological analysis in the Big Data era , 2015, Preventive Veterinary Medicine.