The effect of Ku on telomere replication time is mediated by telomere length but is independent of histone tail acetylation

Ku controls telomere replication timing. We test the mechanism and find that Ku does not bind telomere-proximal origins directly or alter their histone acetylation state. Instead, Ku's effect on replication timing is mediated through telomere length and requires the TG1-3 repeat-counting component Rif1.

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