Identifying Distinctive Acoustic and Spectral Features in Parkinson's Disease

In this paper we try to identify spectral and acoustic features that are distinctive of Parkinson’s disease patients’ speech. We investigate the contribution of several features’ families to a simple classification task that distinguishes between two balanced groups – patients with Parkinson’s disease and their age and gender matched group of Healthy Controls, both uttering sustained vowels. We achieve over 75% correct classification using a combination of acoustic and spectral features. We show that combining a few statistical functionals of these features yields very good results.. This can be explained by two reasons: the first is that the statistics of Parkinson’s disease patients’ speech defer from those of Healthy people’s speech; the second and more important one is the gradual nature of the Parkinsonian speech that is manifested by the changes within an utterance. We speculate that the feature families that most contribute to the classification task are the most distinctive for detecting the disease and suggest testing this hypothesis by performing long-term analysis of both patient and healthy control subjects. Similar accuracy is obtained when analyzing spontaneous speech where each utterance is represented by a single normalized i-vector.

[1]  Elmar Nöth,et al.  Apkinson - A Mobile Monitoring Solution for Parkinson's Disease , 2017, INTERSPEECH.

[2]  Nir Giladi,et al.  Interdisciplinary Teamwork for the Treatment of People with Parkinson’s Disease and Their Families , 2014, Current Neurology and Neuroscience Reports.

[3]  Walter Karlen,et al.  PhoneMD: Learning to Diagnose Parkinson's Disease from Smartphone Data , 2018, AAAI.

[4]  P ? ? ? ? ? ? ? % ? ? ? ? , 1991 .

[5]  G. Schulz,et al.  Effects of speech therapy and pharmacologic and surgical treatments on voice and speech in Parkinson's disease: a review of the literature. , 2000, Journal of communication disorders.

[6]  P. van de Heyning,et al.  Test-retest study of the GRBAS scale: influence of experience and professional background on perceptual rating of voice quality. , 1997, Journal of voice : official journal of the Voice Foundation.

[7]  Navnath S. Nehe,et al.  DWT and LPC based feature extraction methods for isolated word recognition , 2012, EURASIP Journal on Audio, Speech, and Music Processing.

[8]  John B. Shoven,et al.  I , Edinburgh Medical and Surgical Journal.

[9]  Atanu Biswas,et al.  Epidemiology of Parkinson’s Disease , 2018 .

[10]  Kevin Barraclough,et al.  I and i , 2001, BMJ : British Medical Journal.

[11]  Madeleine. E. Hackney,et al.  The Four Square Step Test in individuals with Parkinson's disease: association with executive function and comparison with older adults. , 2014, NeuroRehabilitation.

[12]  Libby J. Smith,et al.  Voice Outcome following Acute Unilateral Vocal Fold Paralysis , 2013, The Annals of otology, rhinology, and laryngology.

[13]  Meysam Asgari,et al.  Fully automated assessment of the severity of Parkinson's disease from speech , 2015, Comput. Speech Lang..

[14]  J. Logemann,et al.  Frequency and cooccurrence of vocal tract dysfunctions in the speech of a large sample of Parkinson patients. , 1978, The Journal of speech and hearing disorders.

[15]  Patrick Kenny,et al.  Front-End Factor Analysis for Speaker Verification , 2011, IEEE Transactions on Audio, Speech, and Language Processing.

[16]  F. Cardoso,et al.  Idiopathic Parkinson's disease: vocal and quality of life analysis. , 2012, Arquivos de neuro-psiquiatria.

[17]  Juan Ignacio Godino-Llorente,et al.  Analysis of speaker recognition methodologies and the influence of kinetic changes to automatically detect Parkinson's Disease , 2018, Appl. Soft Comput..

[18]  K. Tjaden Speech and Swallowing in Parkinson's Disease , 2008, Topics in geriatric rehabilitation.

[19]  Max A. Little,et al.  Suitability of Dysphonia Measurements for Telemonitoring of Parkinson's Disease , 2008, IEEE Transactions on Biomedical Engineering.

[20]  George D. Magoulas,et al.  Deep learning Parkinson's from smartphone data , 2017, 2017 IEEE International Conference on Pervasive Computing and Communications (PerCom).

[21]  L. Ramig,et al.  Speech and swallowing disorders in Parkinson disease , 2008, Current opinion in otolaryngology & head and neck surgery.