Recent advances in technology for measuring and manipulating cell signals

Signal transduction research has made some glowing progress in the past 12 months. Recent advances in fluorescent proteins, small molecule fluorophores and imaging technology are generating new ways to investigate signal transduction.

[1]  Rebekka M. Wachter,et al.  Sensitivity of the yellow variant of green fluorescent protein to halides and nitrate , 1999, Current Biology.

[2]  M. Chalfie GREEN FLUORESCENT PROTEIN , 1995, Photochemistry and photobiology.

[3]  E M Callaway,et al.  Brominated 7-hydroxycoumarin-4-ylmethyls: photolabile protecting groups with biologically useful cross-sections for two photon photolysis. , 1999, Proceedings of the National Academy of Sciences of the United States of America.

[4]  N. Mahajan,et al.  Novel mutant green fluorescent protein protease substrates reveal the activation of specific caspases during apoptosis. , 1999, Chemistry & biology.

[5]  R. Glockshuber,et al.  Circularly permuted variants of the green fluorescent protein , 1999, FEBS letters.

[6]  R Y Tsien,et al.  Dynamic redistribution of calmodulin in HeLa cells during cell division as revealed by a GFP-calmodulin fusion protein technique. , 1999, Journal of cell science.

[7]  J B Shear,et al.  Photolysis of caged calcium in femtoliter volumes using two-photon excitation. , 1999, Biophysical journal.

[8]  A Miyawaki,et al.  Dynamic and quantitative Ca2+ measurements using improved cameleons. , 1999, Proceedings of the National Academy of Sciences of the United States of America.

[9]  S J Remington,et al.  Mechanism and Cellular Applications of a Green Fluorescent Protein-based Halide Sensor* , 2000, The Journal of Biological Chemistry.

[10]  G. Rutter,et al.  Imaging Ca2+ concentration changes at the secretory vesicle surface with a recombinant targeted cameleon , 1999, Current Biology.

[11]  P. Negulescu,et al.  Cell-based assays and instrumentation for screening ion-channel targets. , 1999, Drug discovery today.

[12]  R. Vale,et al.  Microtubule disassembly by ATP-dependent oligomerization of the AAA enzyme katanin. , 1999, Science.

[13]  N. Doi,et al.  Design of generic biosensors based on green fluorescent proteins with allosteric sites by directed evolution , 1999, FEBS letters.

[14]  A. Kanai,et al.  Role of metallothionein in nitric oxide signaling as revealed by a green fluorescent fusion protein. , 2000, Proceedings of the National Academy of Sciences of the United States of America.

[15]  J. Lakowicz Principles of fluorescence spectroscopy , 1983 .

[16]  S. Lukyanov,et al.  Fluorescent proteins from nonbioluminescent Anthozoa species , 1999, Nature Biotechnology.

[17]  K. Shen,et al.  Dynamic control of CaMKII translocation and localization in hippocampal neurons by NMDA receptor stimulation. , 1999, Science.

[18]  Timothy W. Cacciatore,et al.  Identification of Neural Circuits by Imaging Coherent Electrical Activity with FRET-Based Dyes , 1999, Neuron.

[19]  J. Alexander,et al.  Targeting Expression with Light Using Caged DNA* , 1999, The Journal of Biological Chemistry.

[20]  Peter J. Parker,et al.  Imaging Protein Kinase Cα Activation in Cells , 1999 .

[21]  M. Tanabe,et al.  Spatiotemporal dynamics of inositol 1,4,5-trisphosphate that underlies complex Ca2+ mobilization patterns. , 1999, Science.

[22]  Ehud Y Isacoff,et al.  A Genetically Encoded Optical Probe of Membrane Voltage , 1997, Neuron.

[23]  Susan S. Taylor,et al.  A genetically encoded, fluorescent indicator for cyclic AMP in living cells , 1999, Nature Cell Biology.

[24]  G. Caponigro,et al.  Green fluorescent protein as a scaffold for intracellular presentation of peptides. , 1998, Nucleic acids research.

[25]  Francisco Bezanilla,et al.  Atomic scale movement of the voltage-sensing region in a potassium channel measured via spectroscopy , 1999, Nature.

[26]  M. Bond,et al.  Cyclic AMP-dependent Protein Kinase Binding to A-kinase Anchoring Proteins in Living Cells by Fluorescence Resonance Energy Transfer of Green Fluorescent Protein Fusion Proteins* , 1999, The Journal of Biological Chemistry.

[27]  A. Persechini,et al.  The Relationship between the Free Concentrations of Ca2+ and Ca2+-calmodulin in Intact Cells* , 1999, The Journal of Biological Chemistry.

[28]  R. Tsien,et al.  Circular permutation and receptor insertion within green fluorescent proteins. , 1999, Proceedings of the National Academy of Sciences of the United States of America.

[29]  M. Caron,et al.  Real-time Visualization of the Cellular Redistribution of G Protein-coupled Receptor Kinase 2 and β-Arrestin 2 during Homologous Desensitization of the Substance P Receptor* , 1999, The Journal of Biological Chemistry.

[30]  K. Svoboda,et al.  Rapid spine delivery and redistribution of AMPA receptors after synaptic NMDA receptor activation. , 1999, Science.

[31]  M H Ellisman,et al.  Video-rate scanning two-photon excitation fluorescence microscopy and ratio imaging with cameleons. , 1999, Biophysical journal.

[32]  C. Johnson,et al.  A bioluminescence resonance energy transfer (BRET) system: application to interacting circadian clock proteins. , 1999, Proceedings of the National Academy of Sciences of the United States of America.