Interaction networks of lithium and valproate molecular targets reveal a striking enrichment of apoptosis functional clusters and neurotrophin signaling

[1]  Allan Kuchinsky,et al.  GLay: community structure analysis of biological networks , 2010, Bioinform..

[2]  K. Kultima,et al.  Early transcriptional responses in mouse embryos as a basis for selection of molecular markers predictive of valproic acid teratogenicity. , 2010, Reproductive toxicology.

[3]  S. Cichon,et al.  The International Consortium on Lithium Genetics (ConLiGen): an initiative by the NIMH and IGSLI to study the genetic basis of response to lithium treatment. , 2010, Neuropsychobiology.

[4]  T. Bayer,et al.  Histone Deacetylase Inhibitor Valproic Acid Inhibits Cancer Cell Proliferation via Down-regulation of the Alzheimer Amyloid Precursor Protein* , 2010, The Journal of Biological Chemistry.

[5]  K. Iwamoto,et al.  Effect of mood stabilizers on gene expression in lymphoblastoid cells , 2010, Journal of Neural Transmission.

[6]  Akira Sawa,et al.  Understanding the Role of DISC1 in Psychiatric Disease and during Normal Development , 2009, The Journal of Neuroscience.

[7]  P. S. Klein,et al.  Validating GSK3 as an in vivo target of lithium action. , 2009, Biochemical Society transactions.

[8]  S. Fatemi,et al.  The role of lithium in modulation of brain genes: relevance for aetiology and treatment of bipolar disorder. , 2009, Biochemical Society transactions.

[9]  Xin Duan,et al.  DISC1 Regulates New Neuron Development in the Adult Brain via Modulation of AKT-mTOR Signaling through KIAA1212 , 2009, Neuron.

[10]  I. Takasaki,et al.  Valproic acid induces up- or down-regulation of gene expression responsible for the neuronal excitation and inhibition in rat cortical neurons through its epigenetic actions , 2009, Neuroscience Research.

[11]  P Mineur,et al.  Antileukemic activity of valproic acid in chronic lymphocytic leukemia B cells defined by microarray analysis , 2009, Leukemia.

[12]  M. Alda,et al.  Lithium: a key to the genetics of bipolar disorder , 2009, Genome Medicine.

[13]  T. McGraw,et al.  The Akt kinases: Isoform specificity in metabolism and cancer , 2009, Cell cycle.

[14]  V. Willour,et al.  Family‐based association study of Neuregulin 1 with psychotic bipolar disorder , 2009, American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics.

[15]  Tyrone D. Cannon,et al.  Association of AKT1 with verbal learning, verbal memory, and regional cortical gray matter density in twins , 2009, American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics.

[16]  Jianxin Shi,et al.  Common variants on chromosome 6p22.1 are associated with schizophrenia , 2009, Nature.

[17]  S. Purcell,et al.  A genomewide association study of response to lithium for prevention of recurrence in bipolar disorder. , 2009, The American journal of psychiatry.

[18]  M. K. Kim,et al.  Human Neural Stem Cells Genetically Modified to Overexpress Akt1 Provide Neuroprotection and Functional Improvement in Mouse Stroke Model , 2009, PloS one.

[19]  Amy S. Lee,et al.  Transcriptional induction of GRP78/BiP by histone deacetylase inhibitors and resistance to histone deacetylase inhibitor–induced apoptosis , 2009, Molecular Cancer Therapeutics.

[20]  R. Gainetdinov,et al.  Akt/GSK3 signaling in the action of psychotropic drugs. , 2009, Annual review of pharmacology and toxicology.

[21]  D. Burkin,et al.  Valproic acid activates the PI3K/Akt/mTOR pathway in muscle and ameliorates pathology in a mouse model of Duchenne muscular dystrophy. , 2009, The American journal of pathology.

[22]  Kim Kultima,et al.  Valproic acid-induced deregulation in vitro of genes associated in vivo with neural tube defects. , 2009, Toxicological sciences : an official journal of the Society of Toxicology.

[23]  Li-Huei Tsai,et al.  Disrupted in Schizophrenia 1 Regulates Neuronal Progenitor Proliferation via Modulation of GSK3β/β-Catenin Signaling , 2009, Cell.

[24]  James E Ferrell Q&A: Systems biology , 2009, Journal of biology.

[25]  S. Detera-Wadleigh,et al.  Decoding the Genetics and Underlying Mechanisms of Mood Disorders Sevilla D. Detera-Wadleigh and Takeo Yoshikawa , 2009 .

[26]  Jing Gao,et al.  Integrating and annotating the interactome using the MiMI plugin for cytoscape , 2009, Bioinform..

[27]  Z. Marinova,et al.  The mood stabilizers lithium and valproate selectively activate the promoter IV of brain-derived neurotrophic factor in neurons , 2009, Molecular Psychiatry.

[28]  H. Manji,et al.  Evidence for Involvement of ERK, PI3K, and RSK in Induction of Bcl-2 by Valproate , 2009, Journal of Molecular Neuroscience.

[29]  O. Forlenza,et al.  Lithium reduces Gsk3b mRNA levels: implications for Alzheimer Disease , 2009, European Archives of Psychiatry and Clinical Neuroscience.

[30]  D. Chuang,et al.  Histone deacetylase inhibitors up-regulate astrocyte GDNF and BDNF gene transcription and protect dopaminergic neurons. , 2008, The international journal of neuropsychopharmacology.

[31]  M. Corena-McLeod,et al.  Paliperidone as a mood stabilizer: A pre-frontal cortex synaptoneurosomal proteomics comparison with lithium and valproic acid after chronic treatment reveals similarities in protein expression , 2008, Brain Research.

[32]  Manuel A. R. Ferreira,et al.  Collaborative genome-wide association analysis supports a role for ANK3 and CACNA1C in bipolar disorder , 2008, Nature Genetics.

[33]  Hideyuki Kobayashi,et al.  Regulation of Akt mRNA and protein levels by glycogen synthase kinase-3beta in adrenal chromaffin cells: effects of LiCl and SB216763. , 2008, European journal of pharmacology.

[34]  Y. Yonekura,et al.  Neuroprotective effect of chronic lithium treatment against hypoxia in specific brain regions with upregulation of cAMP response element binding protein and brain-derived neurotrophic factor but not nerve growth factor: comparison with acute lithium treatment. , 2008, Bipolar disorders.

[35]  P. Mitchell,et al.  Microarray gene expression profiling of mouse brain mRNA in a model of lithium treatment , 2008, Psychiatric genetics.

[36]  Z. Marinova,et al.  Synergistic Neuroprotective Effects of Lithium and Valproic Acid or Other Histone Deacetylase Inhibitors in Neurons: Roles of Glycogen Synthase Kinase-3 Inhibition , 2008, The Journal of Neuroscience.

[37]  P. Agre,et al.  Proteomic analysis of lithium-induced nephrogenic diabetes insipidus: Mechanisms for aquaporin 2 down-regulation and cellular proliferation , 2008, Proceedings of the National Academy of Sciences.

[38]  M. Casanova,et al.  Deciphering the lithium transcriptome: Microarray profiling of lithium-modulated gene expression in human neuronal cells , 2008, Neuroscience.

[39]  Alan E Hubbard,et al.  Pharmacogenetic Analysis of Lithium-induced Delayed Aging in Caenorhabditis elegans* , 2008, Journal of Biological Chemistry.

[40]  Brad T. Sherman,et al.  Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources , 2008, Nature Protocols.

[41]  Yasushi Kobayashi,et al.  Behavioral / Systems / Cognitive Extracellular Signal-Regulated Kinase 2 ( ERK 2 ) Knockdown Mice Show Deficits in Long-Term Memory ; ERK 2 Has a Specific Function in Learning and Memory , 2007 .

[42]  H. Gurling,et al.  A microarray gene expression study of the molecular pharmacology of lithium carbonate on mouse brain mRNA to understand the neurobiology of mood stabilization and treatment of bipolar affective disorder , 2007, Pharmacogenetics and genomics.

[43]  H. Lehrach,et al.  A global view of gene expression in lithium and zinc treated sea urchin embryos: new components of gene regulatory networks , 2007, Genome Biology.

[44]  M. Szyf,et al.  Valproate induces widespread epigenetic reprogramming which involves demethylation of specific genes. , 2007, Carcinogenesis.

[45]  Bin Liu,et al.  Michigan Molecular Interactions (MiMI): putting the jigsaw puzzle together , 2006, Nucleic Acids Res..

[46]  Lithium increases bcl-2 expression in chick cochlear nucleus and protects against deafferentation-induced cell death , 2006, Neuroscience.

[47]  Jihong Chen,et al.  Valproic acid and butyrate induce apoptosis in human cancer cells through inhibition of gene expression of Akt/protein kinase B , 2006, Molecular Cancer.

[48]  P. Pavlidis,et al.  Akt1 deficiency affects neuronal morphology and predisposes to abnormalities in prefrontal cortex functioning , 2006, Proceedings of the National Academy of Sciences.

[49]  K. Fukunaga,et al.  Lithium-induced activation of Akt and CaM kinase II contributes to its neuroprotective action in a rat microsphere embolism model , 2006, Brain Research.

[50]  B. Dean,et al.  Genome-wide expression analysis detects eight genes with robust alterations specific to bipolar I disorder: relevance to neuronal network perturbation. , 2006, Human molecular genetics.

[51]  P. Mitchell,et al.  Altered gene expression in mice treated with the mood stabilizer sodium valproate. , 2006, The international journal of neuropsychopharmacology.

[52]  Q. Duh,et al.  Valproic acid inhibits growth, induces apoptosis, and modulates apoptosis-regulatory and differentiation gene expression in human thyroid cancer cells. , 2005, Surgery.

[53]  Wolfgang Schmidt-Heck,et al.  Dynamic Network Reconstruction from Gene Expression Data Describing the Effect of LiCl Stimulation on Hepatocytes , 2005, J. Integr. Bioinform..

[54]  M. Ozturk,et al.  Lithium‐mediated downregulation of PKB/Akt and cyclin E with growth inhibition in hepatocellular carcinoma cells , 2005, International journal of cancer.

[55]  M. Alda,et al.  Investigating responders to lithium prophylaxis as a strategy for mapping susceptibility genes for bipolar disorder , 2005, Progress in Neuro-Psychopharmacology and Biological Psychiatry.

[56]  F. Bosetti,et al.  Microarray analysis of rat brain gene expression after chronic administration of sodium valproate , 2005, Brain Research Bulletin.

[57]  W. Lieberthal,et al.  Lithium activates the Wnt and phosphatidylinositol 3-kinase Akt signaling pathways to promote cell survival in the absence of soluble survival factors. , 2005, American journal of physiology. Renal physiology.

[58]  Robert L. Phillips,et al.  Regulation of Gene Expression by Lithium and Depletion of Inositol in Slices of Adult Rat Cortex , 2005, Neuron.

[59]  F. Villarroya,et al.  Lithium inhibits brown adipocyte differentiation , 2005, FEBS letters.

[60]  Jerome F Strauss,et al.  Valproate-induced alterations in human theca cell gene expression: clues to the association between valproate use and metabolic side effects. , 2005, Physiological genomics.

[61]  G. Werstuck,et al.  Valproate protects cells from ER stress-induced lipid accumulation and apoptosis by inhibiting glycogen synthase kinase-3 , 2005, Journal of Cell Science.

[62]  N. Stott,et al.  Early gene response in lithium chloride induced apoptosis , 2005, Apoptosis.

[63]  R. Belmaker,et al.  Bipolar disorder: Treatment. , 2004, Discovery medicine.

[64]  N. Schork,et al.  Candidate genes, pathways and mechanisms for bipolar (manic–depressive) and related disorders: an expanded convergent functional genomics approach , 2004, Molecular Psychiatry.

[65]  Andrew L. Lemire,et al.  Comparison of microarray-based mRNA profiling technologies for identification of psychiatric disease and drug signatures , 2004, Journal of Neuroscience Methods.

[66]  Guang Chen,et al.  Mood Stabilizer Valproate Promotes ERK Pathway-Dependent Cortical Neuronal Growth and Neurogenesis , 2004, The Journal of Neuroscience.

[67]  K. Kultima,et al.  Valproic Acid Teratogenicity: A Toxicogenomics Approach , 2004, Environmental health perspectives.

[68]  M. Karayiorgou,et al.  Convergent evidence for impaired AKT1-GSK3β signaling in schizophrenia , 2004, Nature Genetics.

[69]  R. Belmaker,et al.  Bipolar disorder. , 2004, The New England journal of medicine.

[70]  F. Angelucci,et al.  Lithium treatment alters brain concentrations of nerve growth factor, brain-derived neurotrophic factor and glial cell line-derived neurotrophic factor in a rat model of depression. , 2003, The international journal of neuropsychopharmacology.

[71]  Christoffer Bro,et al.  Transcriptional, Proteomic, and Metabolic Responses to Lithium in Galactose-grown Yeast Cells* , 2003, Journal of Biological Chemistry.

[72]  H. Manji,et al.  The Role of the Extracellular Signal-Regulated Kinase Signaling Pathway in Mood Modulation , 2003, The Journal of Neuroscience.

[73]  R. Belmaker,et al.  The effect of lithium on expression of genes for inositol biosynthetic enzymes in mouse hippocampus; a comparison with the yeast model. , 2003, Brain research. Molecular brain research.

[74]  S. Detera-Wadleigh,et al.  Analysis of a cluster of polymorphisms in AKT1 gene in bipolar pedigrees: a family-based association study , 2003, Neuroscience Letters.

[75]  M. Wilson,et al.  Regional changes in rat brain inositol monophosphatase 1 (IMPase 1) activity with chronic lithium treatment , 2003, Progress in Neuro-Psychopharmacology and Biological Psychiatry.

[76]  H. Manji,et al.  Support of retinal ganglion cell survival and axon regeneration by lithium through a Bcl-2-dependent mechanism. , 2003, Investigative ophthalmology & visual science.

[77]  Xiaohua Li,et al.  Regulation of Akt and glycogen synthase kinase-3β phosphorylation by sodium valproate and lithium , 2002, Neuropharmacology.

[78]  D. Chuang,et al.  Lithium induces brain-derived neurotrophic factor and activates TrkB in rodent cortical neurons: An essential step for neuroprotection against glutamate excitotoxicity , 2002, Neuropharmacology.

[79]  H. Stefánsson,et al.  Neuregulin 1 and susceptibility to schizophrenia. , 2002, American journal of human genetics.

[80]  David P Wolfer,et al.  Knockout of ERK1 MAP Kinase Enhances Synaptic Plasticity in the Striatum and Facilitates Striatal-Mediated Learning and Memory , 2002, Neuron.

[81]  D. Chuang,et al.  Neuroprotective effects of lithium in cultured cells and animal models of diseases. , 2002, Bipolar disorders.

[82]  S. Rapoport,et al.  Analysis of gene expression with cDNA microarrays in rat brain after 7 and 42 days of oral lithium administration , 2002, Brain Research Bulletin.

[83]  Ping Zhu,et al.  Valproic acid defines a novel class of HDAC inhibitors inducing differentiation of transformed cells , 2001, The EMBO journal.

[84]  Y. Okamoto,et al.  Chronic lithium treatment increases the expression of brain-derived neurotrophic factor in the rat brain , 2001, Psychopharmacology.

[85]  M. Guenther,et al.  Histone Deacetylase Is a Direct Target of Valproic Acid, a Potent Anticonvulsant, Mood Stabilizer, and Teratogen* , 2001, The Journal of Biological Chemistry.

[86]  D J Porteous,et al.  Schizophrenia and affective disorders--cosegregation with a translocation at chromosome 1q42 that directly disrupts brain-expressed genes: clinical and P300 findings in a family. , 2001, American journal of human genetics.

[87]  G. Moore,et al.  Bipolar disorder: leads from the molecular and cellular mechanisms of action of mood stabilisers , 2001, British Journal of Psychiatry.

[88]  S. Detera-Wadleigh Lithium-related genetics of bipolar disorder. , 2001, Annals of medicine.

[89]  G. Moore,et al.  Bipolar disorder: leads from the molecular and cellular mechanisms of action of mood stabilizers. , 2001, The British journal of psychiatry. Supplement.

[90]  C. Gundersen,et al.  Lithium Ions Up‐Regulate mRNAs Encoding Dense‐Core Vesicle Proteins in Nerve Growth Factor‐Differentiated PC12 Cells , 2000, Journal of neurochemistry.

[91]  Martin S. Taylor,et al.  Disruption of two novel genes by a translocation co-segregating with schizophrenia. , 2000, Human molecular genetics.

[92]  D. Chuang,et al.  Lithium activates the serine/threonine kinase Akt-1 and suppresses glutamate-induced inhibition of Akt-1 activity in neurons. , 1999, Proceedings of the National Academy of Sciences of the United States of America.

[93]  D. Chuang,et al.  Long Term Lithium Treatment Suppresses p53 and Bax Expression but Increases Bcl-2 Expression , 1999, The Journal of Biological Chemistry.

[94]  C. Bown,et al.  Differential display PCR reveals novel targets for the mood-stabilizing drug valproate including the molecular chaperone GRP78. , 1999, Molecular pharmacology.

[95]  H. Manji,et al.  The Mood‐Stabilizing Agents Lithium and Valproate RobustlIncrease the Levels of the Neuroprotective Protein bcl‐2 in the CNS , 1999, Journal of neurochemistry.

[96]  K. Giacomini,et al.  Characterization of a bioengineered chimeric Na+-nucleoside transporter. , 1999, Molecular pharmacology.

[97]  S. Cory,et al.  The Bcl-2 protein family: arbiters of cell survival. , 1998, Science.

[98]  R. Lenox,et al.  Sodium valproate down-regulates the myristoylated alanine-rich C kinase substrate (MARCKS) in immortalized hippocampal cells: a property of protein kinase C-mediated mood stabilizers. , 1998, The Journal of pharmacology and experimental therapeutics.

[99]  D. Melton,et al.  A molecular mechanism for the effect of lithium on development. , 1996, Proceedings of the National Academy of Sciences of the United States of America.

[100]  Edda Klipp,et al.  Systems Biology , 1994 .

[101]  D. Clair,et al.  Association within a family of a balanced autosomal translocation with major mental illness , 1990, The Lancet.

[102]  Michael J. Berridge,et al.  Neural and developmental actions of lithium: A unifying hypothesis , 1989, Cell.

[103]  W. Sherman,et al.  The effects of lithium ion and other agents on the activity of myo-inositol-1-phosphatase from bovine brain. , 1980, The Journal of biological chemistry.

[104]  Lithium salts in the treatment of psychotic excitement. , 1949, The Medical journal of Australia.