Interaction networks of lithium and valproate molecular targets reveal a striking enrichment of apoptosis functional clusters and neurotrophin signaling
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F. McMahon | T. Schulze | N. Akula | S. Detera-Wadleigh | V. Nagarajan | W. Corona | Ajay Gupta | Xueying Jiang | Natasha Hunter | Xue-ying Jiang | Ajay Gupta | Natasha Hunter | Francis J. McMahon | Francis J McMahon
[1] Allan Kuchinsky,et al. GLay: community structure analysis of biological networks , 2010, Bioinform..
[2] K. Kultima,et al. Early transcriptional responses in mouse embryos as a basis for selection of molecular markers predictive of valproic acid teratogenicity. , 2010, Reproductive toxicology.
[3] S. Cichon,et al. The International Consortium on Lithium Genetics (ConLiGen): an initiative by the NIMH and IGSLI to study the genetic basis of response to lithium treatment. , 2010, Neuropsychobiology.
[4] T. Bayer,et al. Histone Deacetylase Inhibitor Valproic Acid Inhibits Cancer Cell Proliferation via Down-regulation of the Alzheimer Amyloid Precursor Protein* , 2010, The Journal of Biological Chemistry.
[5] K. Iwamoto,et al. Effect of mood stabilizers on gene expression in lymphoblastoid cells , 2010, Journal of Neural Transmission.
[6] Akira Sawa,et al. Understanding the Role of DISC1 in Psychiatric Disease and during Normal Development , 2009, The Journal of Neuroscience.
[7] P. S. Klein,et al. Validating GSK3 as an in vivo target of lithium action. , 2009, Biochemical Society transactions.
[8] S. Fatemi,et al. The role of lithium in modulation of brain genes: relevance for aetiology and treatment of bipolar disorder. , 2009, Biochemical Society transactions.
[9] Xin Duan,et al. DISC1 Regulates New Neuron Development in the Adult Brain via Modulation of AKT-mTOR Signaling through KIAA1212 , 2009, Neuron.
[10] I. Takasaki,et al. Valproic acid induces up- or down-regulation of gene expression responsible for the neuronal excitation and inhibition in rat cortical neurons through its epigenetic actions , 2009, Neuroscience Research.
[11] P Mineur,et al. Antileukemic activity of valproic acid in chronic lymphocytic leukemia B cells defined by microarray analysis , 2009, Leukemia.
[12] M. Alda,et al. Lithium: a key to the genetics of bipolar disorder , 2009, Genome Medicine.
[13] T. McGraw,et al. The Akt kinases: Isoform specificity in metabolism and cancer , 2009, Cell cycle.
[14] V. Willour,et al. Family‐based association study of Neuregulin 1 with psychotic bipolar disorder , 2009, American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics.
[15] Tyrone D. Cannon,et al. Association of AKT1 with verbal learning, verbal memory, and regional cortical gray matter density in twins , 2009, American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics.
[16] Jianxin Shi,et al. Common variants on chromosome 6p22.1 are associated with schizophrenia , 2009, Nature.
[17] S. Purcell,et al. A genomewide association study of response to lithium for prevention of recurrence in bipolar disorder. , 2009, The American journal of psychiatry.
[18] M. K. Kim,et al. Human Neural Stem Cells Genetically Modified to Overexpress Akt1 Provide Neuroprotection and Functional Improvement in Mouse Stroke Model , 2009, PloS one.
[19] Amy S. Lee,et al. Transcriptional induction of GRP78/BiP by histone deacetylase inhibitors and resistance to histone deacetylase inhibitor–induced apoptosis , 2009, Molecular Cancer Therapeutics.
[20] R. Gainetdinov,et al. Akt/GSK3 signaling in the action of psychotropic drugs. , 2009, Annual review of pharmacology and toxicology.
[21] D. Burkin,et al. Valproic acid activates the PI3K/Akt/mTOR pathway in muscle and ameliorates pathology in a mouse model of Duchenne muscular dystrophy. , 2009, The American journal of pathology.
[22] Kim Kultima,et al. Valproic acid-induced deregulation in vitro of genes associated in vivo with neural tube defects. , 2009, Toxicological sciences : an official journal of the Society of Toxicology.
[23] Li-Huei Tsai,et al. Disrupted in Schizophrenia 1 Regulates Neuronal Progenitor Proliferation via Modulation of GSK3β/β-Catenin Signaling , 2009, Cell.
[24] James E Ferrell. Q&A: Systems biology , 2009, Journal of biology.
[25] S. Detera-Wadleigh,et al. Decoding the Genetics and Underlying Mechanisms of Mood Disorders Sevilla D. Detera-Wadleigh and Takeo Yoshikawa , 2009 .
[26] Jing Gao,et al. Integrating and annotating the interactome using the MiMI plugin for cytoscape , 2009, Bioinform..
[27] Z. Marinova,et al. The mood stabilizers lithium and valproate selectively activate the promoter IV of brain-derived neurotrophic factor in neurons , 2009, Molecular Psychiatry.
[28] H. Manji,et al. Evidence for Involvement of ERK, PI3K, and RSK in Induction of Bcl-2 by Valproate , 2009, Journal of Molecular Neuroscience.
[29] O. Forlenza,et al. Lithium reduces Gsk3b mRNA levels: implications for Alzheimer Disease , 2009, European Archives of Psychiatry and Clinical Neuroscience.
[30] D. Chuang,et al. Histone deacetylase inhibitors up-regulate astrocyte GDNF and BDNF gene transcription and protect dopaminergic neurons. , 2008, The international journal of neuropsychopharmacology.
[31] M. Corena-McLeod,et al. Paliperidone as a mood stabilizer: A pre-frontal cortex synaptoneurosomal proteomics comparison with lithium and valproic acid after chronic treatment reveals similarities in protein expression , 2008, Brain Research.
[32] Manuel A. R. Ferreira,et al. Collaborative genome-wide association analysis supports a role for ANK3 and CACNA1C in bipolar disorder , 2008, Nature Genetics.
[33] Hideyuki Kobayashi,et al. Regulation of Akt mRNA and protein levels by glycogen synthase kinase-3beta in adrenal chromaffin cells: effects of LiCl and SB216763. , 2008, European journal of pharmacology.
[34] Y. Yonekura,et al. Neuroprotective effect of chronic lithium treatment against hypoxia in specific brain regions with upregulation of cAMP response element binding protein and brain-derived neurotrophic factor but not nerve growth factor: comparison with acute lithium treatment. , 2008, Bipolar disorders.
[35] P. Mitchell,et al. Microarray gene expression profiling of mouse brain mRNA in a model of lithium treatment , 2008, Psychiatric genetics.
[36] Z. Marinova,et al. Synergistic Neuroprotective Effects of Lithium and Valproic Acid or Other Histone Deacetylase Inhibitors in Neurons: Roles of Glycogen Synthase Kinase-3 Inhibition , 2008, The Journal of Neuroscience.
[37] P. Agre,et al. Proteomic analysis of lithium-induced nephrogenic diabetes insipidus: Mechanisms for aquaporin 2 down-regulation and cellular proliferation , 2008, Proceedings of the National Academy of Sciences.
[38] M. Casanova,et al. Deciphering the lithium transcriptome: Microarray profiling of lithium-modulated gene expression in human neuronal cells , 2008, Neuroscience.
[39] Alan E Hubbard,et al. Pharmacogenetic Analysis of Lithium-induced Delayed Aging in Caenorhabditis elegans* , 2008, Journal of Biological Chemistry.
[40] Brad T. Sherman,et al. Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources , 2008, Nature Protocols.
[41] Yasushi Kobayashi,et al. Behavioral / Systems / Cognitive Extracellular Signal-Regulated Kinase 2 ( ERK 2 ) Knockdown Mice Show Deficits in Long-Term Memory ; ERK 2 Has a Specific Function in Learning and Memory , 2007 .
[42] H. Gurling,et al. A microarray gene expression study of the molecular pharmacology of lithium carbonate on mouse brain mRNA to understand the neurobiology of mood stabilization and treatment of bipolar affective disorder , 2007, Pharmacogenetics and genomics.
[43] H. Lehrach,et al. A global view of gene expression in lithium and zinc treated sea urchin embryos: new components of gene regulatory networks , 2007, Genome Biology.
[44] M. Szyf,et al. Valproate induces widespread epigenetic reprogramming which involves demethylation of specific genes. , 2007, Carcinogenesis.
[45] Bin Liu,et al. Michigan Molecular Interactions (MiMI): putting the jigsaw puzzle together , 2006, Nucleic Acids Res..
[46] Lithium increases bcl-2 expression in chick cochlear nucleus and protects against deafferentation-induced cell death , 2006, Neuroscience.
[47] Jihong Chen,et al. Valproic acid and butyrate induce apoptosis in human cancer cells through inhibition of gene expression of Akt/protein kinase B , 2006, Molecular Cancer.
[48] P. Pavlidis,et al. Akt1 deficiency affects neuronal morphology and predisposes to abnormalities in prefrontal cortex functioning , 2006, Proceedings of the National Academy of Sciences.
[49] K. Fukunaga,et al. Lithium-induced activation of Akt and CaM kinase II contributes to its neuroprotective action in a rat microsphere embolism model , 2006, Brain Research.
[50] B. Dean,et al. Genome-wide expression analysis detects eight genes with robust alterations specific to bipolar I disorder: relevance to neuronal network perturbation. , 2006, Human molecular genetics.
[51] P. Mitchell,et al. Altered gene expression in mice treated with the mood stabilizer sodium valproate. , 2006, The international journal of neuropsychopharmacology.
[52] Q. Duh,et al. Valproic acid inhibits growth, induces apoptosis, and modulates apoptosis-regulatory and differentiation gene expression in human thyroid cancer cells. , 2005, Surgery.
[53] Wolfgang Schmidt-Heck,et al. Dynamic Network Reconstruction from Gene Expression Data Describing the Effect of LiCl Stimulation on Hepatocytes , 2005, J. Integr. Bioinform..
[54] M. Ozturk,et al. Lithium‐mediated downregulation of PKB/Akt and cyclin E with growth inhibition in hepatocellular carcinoma cells , 2005, International journal of cancer.
[55] M. Alda,et al. Investigating responders to lithium prophylaxis as a strategy for mapping susceptibility genes for bipolar disorder , 2005, Progress in Neuro-Psychopharmacology and Biological Psychiatry.
[56] F. Bosetti,et al. Microarray analysis of rat brain gene expression after chronic administration of sodium valproate , 2005, Brain Research Bulletin.
[57] W. Lieberthal,et al. Lithium activates the Wnt and phosphatidylinositol 3-kinase Akt signaling pathways to promote cell survival in the absence of soluble survival factors. , 2005, American journal of physiology. Renal physiology.
[58] Robert L. Phillips,et al. Regulation of Gene Expression by Lithium and Depletion of Inositol in Slices of Adult Rat Cortex , 2005, Neuron.
[59] F. Villarroya,et al. Lithium inhibits brown adipocyte differentiation , 2005, FEBS letters.
[60] Jerome F Strauss,et al. Valproate-induced alterations in human theca cell gene expression: clues to the association between valproate use and metabolic side effects. , 2005, Physiological genomics.
[61] G. Werstuck,et al. Valproate protects cells from ER stress-induced lipid accumulation and apoptosis by inhibiting glycogen synthase kinase-3 , 2005, Journal of Cell Science.
[62] N. Stott,et al. Early gene response in lithium chloride induced apoptosis , 2005, Apoptosis.
[63] R. Belmaker,et al. Bipolar disorder: Treatment. , 2004, Discovery medicine.
[64] N. Schork,et al. Candidate genes, pathways and mechanisms for bipolar (manic–depressive) and related disorders: an expanded convergent functional genomics approach , 2004, Molecular Psychiatry.
[65] Andrew L. Lemire,et al. Comparison of microarray-based mRNA profiling technologies for identification of psychiatric disease and drug signatures , 2004, Journal of Neuroscience Methods.
[66] Guang Chen,et al. Mood Stabilizer Valproate Promotes ERK Pathway-Dependent Cortical Neuronal Growth and Neurogenesis , 2004, The Journal of Neuroscience.
[67] K. Kultima,et al. Valproic Acid Teratogenicity: A Toxicogenomics Approach , 2004, Environmental health perspectives.
[68] M. Karayiorgou,et al. Convergent evidence for impaired AKT1-GSK3β signaling in schizophrenia , 2004, Nature Genetics.
[69] R. Belmaker,et al. Bipolar disorder. , 2004, The New England journal of medicine.
[70] F. Angelucci,et al. Lithium treatment alters brain concentrations of nerve growth factor, brain-derived neurotrophic factor and glial cell line-derived neurotrophic factor in a rat model of depression. , 2003, The international journal of neuropsychopharmacology.
[71] Christoffer Bro,et al. Transcriptional, Proteomic, and Metabolic Responses to Lithium in Galactose-grown Yeast Cells* , 2003, Journal of Biological Chemistry.
[72] H. Manji,et al. The Role of the Extracellular Signal-Regulated Kinase Signaling Pathway in Mood Modulation , 2003, The Journal of Neuroscience.
[73] R. Belmaker,et al. The effect of lithium on expression of genes for inositol biosynthetic enzymes in mouse hippocampus; a comparison with the yeast model. , 2003, Brain research. Molecular brain research.
[74] S. Detera-Wadleigh,et al. Analysis of a cluster of polymorphisms in AKT1 gene in bipolar pedigrees: a family-based association study , 2003, Neuroscience Letters.
[75] M. Wilson,et al. Regional changes in rat brain inositol monophosphatase 1 (IMPase 1) activity with chronic lithium treatment , 2003, Progress in Neuro-Psychopharmacology and Biological Psychiatry.
[76] H. Manji,et al. Support of retinal ganglion cell survival and axon regeneration by lithium through a Bcl-2-dependent mechanism. , 2003, Investigative ophthalmology & visual science.
[77] Xiaohua Li,et al. Regulation of Akt and glycogen synthase kinase-3β phosphorylation by sodium valproate and lithium , 2002, Neuropharmacology.
[78] D. Chuang,et al. Lithium induces brain-derived neurotrophic factor and activates TrkB in rodent cortical neurons: An essential step for neuroprotection against glutamate excitotoxicity , 2002, Neuropharmacology.
[79] H. Stefánsson,et al. Neuregulin 1 and susceptibility to schizophrenia. , 2002, American journal of human genetics.
[80] David P Wolfer,et al. Knockout of ERK1 MAP Kinase Enhances Synaptic Plasticity in the Striatum and Facilitates Striatal-Mediated Learning and Memory , 2002, Neuron.
[81] D. Chuang,et al. Neuroprotective effects of lithium in cultured cells and animal models of diseases. , 2002, Bipolar disorders.
[82] S. Rapoport,et al. Analysis of gene expression with cDNA microarrays in rat brain after 7 and 42 days of oral lithium administration , 2002, Brain Research Bulletin.
[83] Ping Zhu,et al. Valproic acid defines a novel class of HDAC inhibitors inducing differentiation of transformed cells , 2001, The EMBO journal.
[84] Y. Okamoto,et al. Chronic lithium treatment increases the expression of brain-derived neurotrophic factor in the rat brain , 2001, Psychopharmacology.
[85] M. Guenther,et al. Histone Deacetylase Is a Direct Target of Valproic Acid, a Potent Anticonvulsant, Mood Stabilizer, and Teratogen* , 2001, The Journal of Biological Chemistry.
[86] D J Porteous,et al. Schizophrenia and affective disorders--cosegregation with a translocation at chromosome 1q42 that directly disrupts brain-expressed genes: clinical and P300 findings in a family. , 2001, American journal of human genetics.
[87] G. Moore,et al. Bipolar disorder: leads from the molecular and cellular mechanisms of action of mood stabilisers , 2001, British Journal of Psychiatry.
[88] S. Detera-Wadleigh. Lithium-related genetics of bipolar disorder. , 2001, Annals of medicine.
[89] G. Moore,et al. Bipolar disorder: leads from the molecular and cellular mechanisms of action of mood stabilizers. , 2001, The British journal of psychiatry. Supplement.
[90] C. Gundersen,et al. Lithium Ions Up‐Regulate mRNAs Encoding Dense‐Core Vesicle Proteins in Nerve Growth Factor‐Differentiated PC12 Cells , 2000, Journal of neurochemistry.
[91] Martin S. Taylor,et al. Disruption of two novel genes by a translocation co-segregating with schizophrenia. , 2000, Human molecular genetics.
[92] D. Chuang,et al. Lithium activates the serine/threonine kinase Akt-1 and suppresses glutamate-induced inhibition of Akt-1 activity in neurons. , 1999, Proceedings of the National Academy of Sciences of the United States of America.
[93] D. Chuang,et al. Long Term Lithium Treatment Suppresses p53 and Bax Expression but Increases Bcl-2 Expression , 1999, The Journal of Biological Chemistry.
[94] C. Bown,et al. Differential display PCR reveals novel targets for the mood-stabilizing drug valproate including the molecular chaperone GRP78. , 1999, Molecular pharmacology.
[95] H. Manji,et al. The Mood‐Stabilizing Agents Lithium and Valproate RobustlIncrease the Levels of the Neuroprotective Protein bcl‐2 in the CNS , 1999, Journal of neurochemistry.
[96] K. Giacomini,et al. Characterization of a bioengineered chimeric Na+-nucleoside transporter. , 1999, Molecular pharmacology.
[97] S. Cory,et al. The Bcl-2 protein family: arbiters of cell survival. , 1998, Science.
[98] R. Lenox,et al. Sodium valproate down-regulates the myristoylated alanine-rich C kinase substrate (MARCKS) in immortalized hippocampal cells: a property of protein kinase C-mediated mood stabilizers. , 1998, The Journal of pharmacology and experimental therapeutics.
[99] D. Melton,et al. A molecular mechanism for the effect of lithium on development. , 1996, Proceedings of the National Academy of Sciences of the United States of America.
[100] Edda Klipp,et al. Systems Biology , 1994 .
[101] D. Clair,et al. Association within a family of a balanced autosomal translocation with major mental illness , 1990, The Lancet.
[102] Michael J. Berridge,et al. Neural and developmental actions of lithium: A unifying hypothesis , 1989, Cell.
[103] W. Sherman,et al. The effects of lithium ion and other agents on the activity of myo-inositol-1-phosphatase from bovine brain. , 1980, The Journal of biological chemistry.
[104] Lithium salts in the treatment of psychotic excitement. , 1949, The Medical journal of Australia.