A spatially adaptive conditional autoregressive prior for area health data

Abstract Different priors have been suggested to reflect spatial dependence in area health outcomes or in spatial regression residuals. However, to assume that residuals demonstrate spatial clustering only is a strong prior belief and alternatives have been suggested. A scheme suggested by Leroux et al. [B. Leroux, X. Lei, N. Breslow, Estimation of disease rates in small areas: A new mixed model for spatial dependence, in: M. Halloran, D. Berry (Eds.), Statistical Models in Epidemiology, the Environment and Clinical Trials, Springer-Verlag, New York, 1999, pp. 135–178] involves a single set of random effects and a spatial correlation parameter with extreme values corresponding to pure spatial and pure unstructured residual variation. This paper considers a spatially adaptive extension of that prior to reflect the fact that the appropriate mix between local and global smoothing may not be constant across the region being studied. Local smoothing will not be indicated when an area is disparate from its neighbours (e.g. in terms of social or environmental risk factors for the health outcome being considered). The prior for varying spatial correlation parameters may be based on a regression structure which includes possible observed sources of disparity between neighbours. A case study considers probabilities of long term illness in 133 small areas in NE London, with disparities based on a measure of socio-economic deprivation.