Knowledge acquisition and dissemination can facilitate innovation and provide the engine for economic growth and development. Creating and sharing knowledge can be hindered when multiple languages are spoken in geographically diverse regions that are bound together by cultural proximity. Digital libraries help provide the information infrastructure and technology to overcome these challenges and facilitate knowledge sharing by encouraging collaboration and providing information access. This interactive panel session features experts who are working on the frontlines building and implementing programs that utilize DLs to meet these goals in Latin America and the Caribbean. These projects address technical issues related to cross-lingual access, interoperability, and usability as well as organizational issues related to sharing and integrating research and development streams.