Convergent mutations and kinase fusions lead to oncogenic STAT3 activation in anaplastic large cell lymphoma.
暂无分享,去创建一个
A. Rosenwald | W. Chan | D. Weisenburger | S. Pileri | R. Rabadán | M. Piris | B. Falini | L. Cerroni | D. Rossi | G. Gaidano | J. Vialard | L. Kenner | G. Inghirami | M. Paulli | E. Lasorsa | A. Acquaviva | E. Ficarra | J. Iqbal | R. Piva | A. Zamó | L. Shultz | F. Abate | T. Tousseyn | F. Bertoni | M. Ponzoni | M. Gaudiano | R. Crescenzo | A. Rinaldi | M. Todaro | E. Tiacci | F. Tabbò | N. Chiesa | Filomena Di Giacomo | Elisa Spaccarotella | L. Barbarossa | E. Ercole | M. Boi | D. Novero | A. Tzankov | C. Ciardullo | L. Mevellec | Carmela Ciardullo
[1] S. Swerdlow. WHO Classification of Tumours of Haematopoietic and Lymphoid Tissues , 2017 .
[2] S. Pileri,et al. A novel patient-derived tumorgraft model with TRAF1-ALK anaplastic large-cell lymphoma translocation , 2014, Leukemia.
[3] K. Elenitoba-Johnson,et al. A novel recurrent NPM1-TYK2 gene fusion in cutaneous CD30-positive lymphoproliferative disorders. , 2014, Blood.
[4] Chris Wiggins,et al. Pegasus: a comprehensive annotation and prediction tool for detection of driver gene fusions in cancer , 2014, BMC Systems Biology.
[5] W. Wilson,et al. ALK-negative anaplastic large cell lymphoma is a genetically heterogeneous disease with widely disparate clinical outcomes. , 2014, Blood.
[6] K. Elenitoba-Johnson,et al. Integrated genomic sequencing reveals mutational landscape of T-cell prolymphocytic leukemia. , 2014, Blood.
[7] Adam R. Johnson,et al. Structure of the pseudokinase–kinase domains from protein kinase TYK2 reveals a mechanism for Janus kinase (JAK) autoinhibition , 2014, Proceedings of the National Academy of Sciences.
[8] M. Stern,et al. Recurrent JAK1 and JAK3 somatic mutations in T-cell prolymphocytic leukemia , 2014, Leukemia.
[9] G. Getz,et al. Comprehensive genomic analysis of rhabdomyosarcoma reveals a landscape of alterations affecting a common genetic axis in fusion-positive and fusion-negative tumors. , 2014, Cancer discovery.
[10] I. Lossos,et al. Recurrent mutations in epigenetic regulators, RHOA and FYN kinase in peripheral T cell lymphomas , 2014, Nature Genetics.
[11] N. Harris,et al. A targeted mutational landscape of angioimmunoblastic T-cell lymphoma. , 2012, Blood.
[12] J. Merker,et al. STAT3 mutations are frequent in CD30+ T-cell lymphomas and T-cell large granular lymphocytic leukemia , 2013, Leukemia.
[13] Jeffrey A. Engelman,et al. Tyrosine kinase gene rearrangements in epithelial malignancies , 2013, Nature Reviews Cancer.
[14] Raul Rabadan,et al. SAVI: a statistical algorithm for variant frequency identification , 2013, BMC Systems Biology.
[15] A. Rosenwald,et al. PRDM1/BLIMP1 is commonly inactivated in anaplastic large T-cell lymphoma. , 2013, Blood.
[16] S. Mustjoki,et al. STAT3 mutations indicate the presence of subclinical T-cell clones in a subset of aplastic anemia and myelodysplastic syndrome patients. , 2013, Blood.
[17] W. Curran,et al. Inhibition of STAT3 by Niclosamide Synergizes with Erlotinib against Head and Neck Cancer , 2013, PloS one.
[18] Angela G. Fleischman,et al. TYK2-STAT1-BCL2 pathway dependence in T-cell acute lymphoblastic leukemia. , 2013, Cancer discovery.
[19] G. Inghirami,et al. The EGFR family members sustain the neoplastic phenotype of ALK+ lung adenocarcinoma via EGR1 , 2013, Oncogenesis.
[20] A. Quintás-Cardama,et al. Molecular Pathways: JAK/STAT Pathway: Mutations, Inhibitors, and Resistance , 2013, Clinical Cancer Research.
[21] B. Firwana,et al. Comprehensive review of JAK inhibitors in myeloproliferative neoplasms , 2013, Therapeutic advances in hematology.
[22] Raul Rabadan,et al. MutComFocal: an integrative approach to identifying recurrent and focal genomic alterations in tumor samples , 2013, BMC Systems Biology.
[23] S. Mustjoki,et al. Somatic STAT3 mutations in large granular lymphocytic leukemia. , 2012, The New England journal of medicine.
[24] Michael L. Wang,et al. Role of the microenvironment in mantle cell lymphoma: IL-6 is an important survival factor for the tumor cells. , 2010, Blood.
[25] S. Salzberg,et al. TopHat-Fusion: an algorithm for discovery of novel fusion transcripts , 2011, Genome Biology.
[26] J. Zucman‐Rossi,et al. Somatic mutations activating STAT3 in human inflammatory hepatocellular adenomas , 2011, The Journal of experimental medicine.
[27] Joseph M. Connors,et al. Oncogenically active MYD88 mutations in human lymphoma , 2011, Nature.
[28] J. Grandis,et al. STAT3 signaling: anticancer strategies and challenges. , 2011, Molecular interventions.
[29] James R Kiefer,et al. Structural and thermodynamic characterization of the TYK2 and JAK3 kinase domains in complex with CP-690550 and CMP-6. , 2010, Journal of molecular biology.
[30] Enzo Medico,et al. Gene expression profiling uncovers molecular classifiers for the recognition of anaplastic large-cell lymphoma within peripheral T-cell neoplasms. , 2010, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.
[31] S. Imbeaud,et al. Frequent in-frame somatic deletions activate gp130 in inflammatory hepatocellular tumours , 2009, Nature.
[32] M. Djokic. ALK− anaplastic large-cell lymphoma is clinically and immunophenotypically different from both ALK+ ALCL and peripheral T-cell lymphoma, not otherwise specified: report from the International Peripheral T-Cell Lymphoma Project , 2009 .
[33] D. Weisenburger,et al. International peripheral T-cell and natural killer/T-cell lymphoma study: pathology findings and clinical outcomes. , 2008, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.
[34] Tsonwin Hai,et al. A potential dichotomous role of ATF3, an adaptive-response gene, in cancer development , 2007, Oncogene.
[35] Kenneth C Anderson,et al. Targeted therapy of multiple myeloma based upon tumor-microenvironmental interactions. , 2007, Experimental hematology.
[36] Lauren B. Smith,et al. Highly aggressive ALK-positive anaplastic large cell lymphoma with a leukemic phase and multi-organ involvement: a report of three cases and a review of the literature , 2007, Annals of Hematology.
[37] Roberto Piva,et al. Functional validation of the anaplastic lymphoma kinase signature identifies CEBPB and BCL2A1 as critical target genes. , 2006, The Journal of clinical investigation.
[38] D. Levy,et al. Stat3 is required for ALK-mediated lymphomagenesis and provides a possible therapeutic target , 2005, Nature Medicine.
[39] M. Privalsky,et al. The role of corepressors in transcriptional regulation by nuclear hormone receptors. , 2004, Annual review of physiology.
[40] R. Chaganti,et al. B cell lymphoma-associated chromosomal translocation involves candidate oncogene lyt-10, homologous to NF-κB p50 , 1991, Cell.
[41] R. Chaganti,et al. B cell lymphoma-associated chromosomal translocation involves candidate oncogene lyt-10, homologous to NF-kappa B p50. , 1991, Cell.