Afferent projection patterns in the auditory brainstem in normal and congenitally deaf white cats

Cochlear implantation in congenitally deaf children is developing to a successful medical tool. Little is known, however, on morphology and pathophysiology of the central auditory system in these auditory deprived children. One form of congenital hearing loss, that seen in the deaf white cat, was investigated to see if there are differences in the afferent pathways from the cochlear nuclei to the inferior colliculus. The retrogradely transported fluorescent tracer diamidino yellow (DY) was injected into different parts of the central nucleus of the inferior colliculus (ICC) of normal cats and deaf white cats. It was found that the main afferent projection patterns in deaf white cats were unchanged in spite of congenital auditory deprivation; minor differences were seen.

[1]  Factors affecting the recording of visual-evoked potentials from the deaf cat primary auditory cortex (AI) , 1980, Brain Research.

[2]  J. Goldberg,et al.  Ascending projections of the lateral lemniscus in the cat and monkey , 1967 .

[3]  S. Stanton,et al.  Neonatal cochlear hearing loss results in developmental abnormalities of the central auditory pathways. , 1993, Acta oto-laryngologica.

[4]  M M Merzenich,et al.  Representation of the cochlea within the inferior colliculus of the cat. , 1974, Brain research.

[5]  H. Killackey,et al.  Ascending auditory projections to the inferior colliculus in the adult gerbil, Meriones unguiculatus , 1983, The Journal of comparative neurology.

[6]  Stephen J. Rebscher,et al.  Changes in the cat cochlear nucleus following neonatal deafening and chronic intracochlear electrical stimulation , 1994, Hearing Research.

[7]  D. Moore,et al.  Projections from the cochlear nucleus to the inferior colliculus in normal and neonatally cochlea‐ablated gerbils , 1985, The Journal of comparative neurology.

[8]  Rainer Hartmann,et al.  A model for prelingual deafness, the congenitally deaf white cat – population statistics and degenerative changes , 1998, Hearing Research.

[9]  L. M. Kitzes,et al.  Some physiological consequences of neonatal cochlear destruction in the inferior colliculus of the gerbil, Meriones unguiculatus , 1984, Brain Research.

[10]  R. Andersen,et al.  Some features of the spatial organization of the central nucleus of the inferior colliculus of the cat , 1978, The Journal of comparative neurology.

[11]  J. Adams.  Ascending projections to the inferior colliculus , 1979, The Journal of comparative neurology.

[12]  D R Moore,et al.  Afferent reorganisation within the superior olivary complex of the gerbil: Development and induction by neonatal, unilateral cochlear removal , 1995, The Journal of comparative neurology.

[13]  C. S. Hallpike,et al.  Observations on the histological features, development and pathogenesis of the inner ear degeneration of the deaf white cat , 1965, Proceedings of the Royal Society of London. Series B. Biological Sciences.

[14]  D. Moore.  Trophic influences of excitatory and inhibitory synapses on neurones in the auditory brain stem , 1992, Neuroreport.

[15]  E. Carlier,et al.  Enhancement of visual responses on the primary auditory cortex of the cat after an early destruction of cochlear receptors , 1977, Brain Research.

[16]  E E Douek,et al.  Effects of unilateral deafening on the cochlear nucleus of the guinea pig at different ages. , 1994, Brain research. Developmental brain research.

[17]  D R Moore,et al.  Auditory brainstem of the ferret: bilateral cochlear lesions in infancy do not affect the number of neurons projecting from the cochlear nucleus to the inferior colliculus. , 1990, Brain research. Developmental brain research.

[18]  H. Kuypers,et al.  Two new fluorescent retrograde neuronal tracers which are transported over long distances , 1980, Neuroscience Letters.

[19]  D R Moore,et al.  Auditory brainstem of the ferret: Effects of unilateral cochlear lesions on cochlear nucleus volume and projections to the inferior colliculus , 1988, The Journal of comparative neurology.

[20]  I. Varela-Nieto,et al.  Development of auditory and vestibular systems , 1983 .

[21]  D. Moore.  Auditory brainstem of the ferret: Long survival following cochlear removal progressively changes projections from the cochlear nucleus to the inferior colliculus , 1994, The Journal of comparative neurology.

[22]  G. C. Thompson,et al.  HRP study of the organization of auditory afferents ascending to central nucleus of inferior colliculus in cat , 1981, The Journal of comparative neurology.

[23]  R. Hartmann,et al.  Response of the primary auditory cortex to electrical stimulation of the auditory nerve in the congenitally deaf white cat , 1997, Hearing Research.

[24]  M. Illert,et al.  Fluorescent compounds as retrograde tracers compared with horseradish peroxidase (HRP). II. A parametric study in the peripheral motor system of the cat , 1982, Journal of Neuroscience Methods.

[25]  E G Jones,et al.  The neuronal organization of the inferior colliculus of the adult cat. I. The central nucleus , 1973, The Journal of comparative neurology.

[26]  Mair Iw.  Hereditary deafness in the white cat. , 1973 .

[27]  D. Moore,et al.  Lateral superior olive projections to the inferior colliculus in normal and unilaterally deafened ferrets , 1995, The Journal of comparative neurology.

[28]  D. Moore,et al.  Effect of altered neuronal activity on cell size in the medial nucleus of the trapezoid body and ventral cochlear nucleus of the gerbil , 1994, The Journal of comparative neurology.

[29]  R. Shepherd,et al.  Effect of chronic electrical stimulation on cochlear nucleus neuron size in normal hearing kittens. , 1993, Acta oto-laryngologica.