Stoichiometric analysis of metabolic networks

A major current challenge in systems biology is to clarify the relationship between structure, function and regulation in complex metabolic networks reconstructed from genomic data. However, dynamic mathematical modeling of large-scale networks meets difficulties as the necessary mechanistic detail and kinetic parameters are rarely available. In contrast, structure-oriented (stoichiometric / constraints-based) analyses only require network topology, which is often well-known.

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