Stochastic resonance as a possible mechanism of amplification of weak electric signals in living cells.

The most important but still unresolved problem in bioelectromagnetics is the interaction of weak electromagnetic fields (EMFs) with living cells. Thermal and other types of noise pose restrictions in cell detection of weak signals. As a consequence, some extant experimental results that indicate low-intensity field effects cannot be accounted for, and this renders the results themselves questionable. One way out of this dead end is to search for possible mechanisms of signal amplification. In this paper, we discuss a general mechanism in which a weak signal is amplified by system noise itself. This mechanism was discovered several years ago in physics and is known, in its simplest form, as a stochastic resonance. It was shown that signal amplification may exceed a factor of 1000, which renders existing estimations of EMF thresholds highly speculative. The applicability of the stochastic resonance concept to cells is discussed particularly with respect to the possible role of the cell membrane in the amplification process.

[1]  Frank Moss,et al.  Noise enhancement of information transfer in crayfish mechanoreceptors by stochastic resonance , 1993, Nature.

[2]  Adi R. Bulsara,et al.  Preface , 1993 .

[3]  T. Litovitz,et al.  The role of coherence time in the effect of microwaves on ornithine decarboxylase activity. , 1993, Bioelectromagnetics.

[4]  Jung,et al.  Collective response in globally coupled bistable systems. , 1992, Physical review. A, Atomic, molecular, and optical physics.

[5]  R. Astumian,et al.  Estimates for ELF effects: noise-based thresholds and the number of experimental conditions required for empirical searches. , 1992, Bioelectromagnetics.

[6]  Jung,et al.  Amplification of small signals via stochastic resonance. , 1991, Physical review. A, Atomic, molecular, and optical physics.

[7]  Wiesenfeld.  Amplification by globally coupled arrays: Coherence and symmetry. , 1991, Physical review. A, Atomic, molecular, and optical physics.

[8]  D Krause,et al.  Effect of coherence time of the applied magnetic field on ornithine decarboxylase activity. , 1991, Biochemical and biophysical research communications.

[9]  Adair,et al.  Constraints on biological effects of weak extremely-low-frequency electromagnetic fields. , 1991, Physical review. A, Atomic, molecular, and optical physics.

[10]  Hu,et al.  Periodically forced Fokker-Planck equation and stochastic resonance. , 1990, Physical review. A, Atomic, molecular, and optical physics.

[11]  P. Hänggi,et al.  Reaction-rate theory: fifty years after Kramers , 1990 .

[12]  R. Astumian,et al.  The response of living cells to very weak electric fields: the thermal noise limit. , 1990, Science.

[13]  Peter Jung,et al.  Thermal activation in bistable systems under external periodic forces , 1989 .

[14]  R. Astumian,et al.  Nonlinear effect of an oscillating electric field on membrane proteins , 1989 .

[15]  Santucci,et al.  Periodically time-modulated bistable systems: Stochastic resonance. , 1989, Physical review. A, General physics.

[16]  Wiesenfeld,et al.  Theory of stochastic resonance. , 1989, Physical review. A, General physics.

[17]  Fox,et al.  Stochastic resonance in a double well. , 1989, Physical review. A, General physics.

[18]  F. Barnes,et al.  Some Possible Limits on the Minimum Electrical Signals of Biological Significance , 1987 .

[19]  Membranes, Electromagnetic Fields and Critical Phenomena , 1987 .

[20]  E. Findl.  Membrane Transduction of Low Energy Level Fields and the Ca++ Hypothesis , 1987 .

[21]  W. R. Adey,et al.  Cell Surface Ionic Phenomena in Transmembrane Signaling to Intracellular Enzyme Systems , 1987 .

[22]  P. Läuger.  Ionic channels with conformational substates. , 1985, Biophysical journal.