HLA types in Turkish children with celiac disease.

The aim of this study was to assess the distribution of human leukocyte antigen (HLA) groups in Turkish children with celiac disease (CD) and to investigate the association of HLA types and clinical manifestations of CD. Seventy-five children with CD were evaluated in two groups: Group I consisted of 45 classical celiac patients (15 males, 6.7+/-3.8 years); Group II consisted of 30 atypical celiac patients (9 males, 9.3+/-4.3 years). The control group consisted of 100 healthy renal transplantation donors. HLA typing was made serologically using standard lymphocytotoxicity techniques. HLA A29, B51, CW5, DR14, DR16, and DQ1 were the most common antigens in the control group. Frequency of HLA B13, CW7, B8, DR7, DR17 and DQ2 was higher in CD patients than in the control group (p<0.005, <0.05, <0.001, <0.001 and <0.001, respectively). The relative risks for HLA DQ2, B8, DR17 and B13 were 14.9, 13.6, 7.1 and 3.6, respectively. Frequency of HLA B35, DR11 and DQ7 was higher in classical CD than atypical CD, while a positive association was found between HLA B8 and atypical CD. A positive association was found between HLA B13, CW7 and DR17 in Turkish celiac patients in addition to HLA B8, DR7 and DQ2. This study also suggested that a correlation may exist between genotype and clinical manifestations.

[1]  R. Troncone,et al.  Latest developments in the pathogenesis and treatment of celiac disease. , 2006, The Journal of pediatrics.

[2]  D. Kamat,et al.  Clinical Guidelines for Celiac Disease in Children: What Does It Mean to the Pediatrician/Family Practitioner? , 2006, Clinical pediatrics.

[3]  W. Caspary,et al.  Celiac disease , 2006, Orphanet journal of rare diseases.

[4]  P. Howdle,et al.  Advances in celiac disease , 2005, Current Opinion in Gastroenterology.

[5]  A. Fasano,et al.  Coeliac disease in children. , 2005, Best practice & research. Clinical gastroenterology.

[6]  E. Seidman,et al.  Guideline for the Diagnosis and Treatment of Celiac Disease in Children : Recommendations of the North American Society for Pediatric Gastroenterology , Hepatology and Nutrition , 2004 .

[7]  W. Treem.  Emerging concepts in celiac disease , 2004, Current opinion in pediatrics.

[8]  P. Howdle,et al.  Advances in celiac disease , 2004, Current opinion in gastroenterology.

[9]  W. Mayr,et al.  Distribution of HLA Class I Alleles Differs in Celiac Disease Patients According to Age of Onset , 2003, Digestive Diseases and Sciences.

[10]  A. Namane,et al.  Alterations of the intestinal transport and processing of gliadin peptides in celiac disease. , 2003, Gastroenterology.

[11]  A. Hasanoğlu,et al.  Pattern of human leukocyte antigens in Turkish children with celiac disease , 2000, Pediatrics international : official journal of the Japan Pediatric Society.

[12]  M. Babron,et al.  Genetics of celiac disease. , 2000, Molecular genetics and metabolism.

[13]  E. Yilmaz,et al.  Human leukocyte antigens in Turkish pediatric celiac patients. , 1999, The Turkish journal of pediatrics.

[14]  E. Thorsby,et al.  Gliadin Specific, HLA DQ2‐Restricted T Cells are Commonly Found in Small Intestinal Biopsies from Coeliac Disease Patients, but not from Controls , 1997, Scandinavian journal of immunology.

[15]  P. Ciclitira,et al.  Molecular biology of coeliac disease. , 1995, Archives of disease in childhood.

[16]  E. Thorsby,et al.  HLA susceptibility genes in celiac disease: genetic mapping and role in pathogenesis. , 1993, Gastroenterology.

[17]  K. Welsh,et al.  HLA class II alleles associated with celiac disease susceptibility in a southern European population. , 1992, Tissue antigens.

[18]  E. Thorsby,et al.  Evidence for a primary association of celiac disease to a particular HLA-DQ alpha/beta heterodimer , 1989, The Journal of experimental medicine.

[19]  G. Corazza,et al.  DR and non-DR Ia allotypes are associated with susceptibility to coeliac disease. , 1985, Gut.

[20]  G. Ferrara,et al.  Evidence that celiac disease is primarily associated with a DC locus allelic specificity. , 1983, Clinical immunology and immunopathology.

[21]  P. Asquith,et al.  HLA and coeliac disease. , 1978, British medical bulletin.

[22]  D. Mann,et al.  Genetic basis of gluten-sensitive enteropathy , 1978 .

[23]  A. Katz,et al.  Gluten-sensitive enteropathy: genetic analysis and organ culture study in 35 families. , 1978, Scandinavian journal of gastroenterology.