Parameter identification of nonlinear delayed dynamical system in microbial fermentation based on biological robustness

In this paper, the nonlinear enzyme-catalytic kinetic system of batch and continuous fermentation in the process of glycerol bio-dissimilation is investigated. On the basis of both glycerol and 1,3-PD pass the cell membrane by active and passive diffusion under substrate-sufficient conditions, we consider the delay of concentration changes on both extracellular substances and intracellular substances. We establish a nonlinear delay dynamical system according to the batch and continuous fermentation of bio-dissimilation of glycerol to 1,3-propanediol(1,3-PD) and we propose an identification problem, in which the biological robustness is taken as a performance index, constrained with nonlinear delay dynamical system. An algorithm is constructed to solve the identification problem and the numerical result shows the values of time delays of glycerol, 3-HPA, 1,3-PD intracellular and extracellular substances. This work will be helpful for deeply understanding the metabolic mechanism of glycerol in batch and continuous fermentation.

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