How to Choose an Animal Model

Much of the experimental work needed to elucidate the basic biological and behavioral mechanisms of aging cannot be conducted with human subjects. The use of animal models is often the best alternative strategy. The problem then becomes, what are the most appropriate models for a particular research question. Making the “right” choice may be the most important factor in the success of the research and in the acceptance of the results by other scientists.

[1]  W. Calder,et al.  Body Size and Longevity in Birds , 1976 .

[2]  S. Austad,et al.  Birds as animal models for the comparative biology of aging: a prospectus. , 1995, The journals of gerontology. Series A, Biological sciences and medical sciences.

[3]  M. H. Ross Length of life and nutrition in the rat. , 1961, The Journal of nutrition.

[4]  T. Johnson,et al.  Aging can be genetically dissected into component processes using long-lived lines of Caenorhabditis elegans. , 1987, Proceedings of the National Academy of Sciences of the United States of America.

[5]  L. Luckinbill,et al.  SELECTION FOR DELAYED SENESCENCE IN DROSOPHILA MELANOGASTER , 1984, Evolution; international journal of organic evolution.

[6]  E. Masoro Food restriction in rodents: an evaluation of its role in the study of aging. , 1988, Journal of gerontology.

[7]  R. Martin Primate origins and evolution , 1990 .

[8]  R. Pearl,et al.  Experimental Studies on the Duration of Life. I. Introductory Discussion of the Duration of Life in Drosophila , 1921, The American Naturalist.

[9]  L. Maynard,et al.  Retarded Growth, Life Span, Ultimate Body Size and Age Changes in the Albino Rat after Feeding Diets Restricted in Calories Four Figures , 1939 .

[10]  Michael R Rose,et al.  LABORATORY EVOLUTION OF POSTPONED SENESCENCE IN DROSOPHILA MELANOGASTER , 1984, Evolution; international journal of organic evolution.

[11]  M. Elias,et al.  Hormones, Aging and Behavior in Infrahuman Mammals , 1975 .

[12]  G. Sacher,et al.  Longevity, aging and comparative cellular and molecular biology of the house mouse, Mus musculus, and the white-footed mouse, Peromyscus leucopus. , 1978, Birth defects original article series.

[13]  A. Dickerman,et al.  DNA Hybridization and Rodent Phylogeny , 1993 .

[14]  R. Robertson,et al.  Dietary restriction : implications for the design and interpretation of toxicity and carcinogenicity studies , 1995 .

[15]  Mouse and rat genotype choices , 1997, Experimental Gerontology.

[16]  Ross Mh Nutrition and longevity in experimental animals. , 1976 .

[17]  B. Fadem,et al.  Care and breeding of the gray, short-tailed opossum (Monodelphis domestica) , 1982, Laboratory animal science.

[18]  J. Senar,et al.  Survival and mean life span of the quail Coturnix c. coturnix , 1992 .

[19]  C M McCay,et al.  The effect of retarded growth upon the length of life span and upon the ultimate body size. 1935. , 1935, Nutrition.

[20]  T. Johnson,et al.  Increased life-span of age-1 mutants in Caenorhabditis elegans and lower Gompertz rate of aging. , 1990, Science.

[21]  E. Masoro Animal Models in Aging Research , 1990 .

[22]  J. Northrop THE EFFECT OF PROLONGATION OF THE PERIOD OF GROWTH ON THE TOTAL DURATION OF LIFE , 1917 .

[23]  S. Austad The comparative perspective and choice of animal models in aging research , 1993, Aging.

[24]  S. Austad,et al.  Selecting animal models of human aging: inbred strains often exhibit less biological uniformity than F1 hybrids. , 1994, Journal of gerontology.

[25]  R. Sprott Development of animal models of aging at the national institute on aging , 1991, Neurobiology of Aging.

[26]  D. Bailey RECOMBINANT‐INBRED STRAINS AN AID TO FINDING IDENTITY, LINKAGE, AND FUNCTION OF HISTOCOMPATIBILITY AND OTHER GENES , 1971, Transplantation.

[27]  Caleb E. Finch,et al.  Longevity, senescence, and the genome , 1990 .

[28]  P. Kaufman,et al.  Dietary restriction of adult male rhesus monkeys: design, methodology, and preliminary findings from the first year of study. , 1993, Journal of gerontology.

[29]  C. Mccay,et al.  Chemical and pathological changes in aging and after retarded growth. , 1939 .

[30]  M. Lovett,et al.  Transgenic mice with increased Cu/Zn-superoxide dismutase activity: animal model of dosage effects in Down syndrome. , 1987, Proceedings of the National Academy of Sciences of the United States of America.

[31]  Arthur Mangun Banta,et al.  A study of longevity, growth, reproduction and heart rate in Daphnia longispina as influenced by limitations in quantity of food , 1937 .

[32]  R. Bronson,et al.  Reduction in rate of occurrence of age related lesions in dietary restricted laboratory mice. , 1991, Growth, development, and aging : GDA.

[33]  G. Mcclearn,et al.  Selection of an appropriate animal model to study aging processes with special emphasis on the use of rat strains. , 1992, Journal of gerontology.