Blockade of 6-phosphogluconate dehydrogenase generates CD8+ effector T cells with enhanced anti-tumor function
暂无分享,去创建一个
T. Fan | R. Higashi | Penghui Lin | V. Boussiotis | P. Seth | S. Daneshmandi | G. Wulf | Teresa A. Cassel
[1] J. Rabinowitz,et al. A small molecule G6PD inhibitor reveals immune dependence on pentose phosphate pathway , 2020, Nature Chemical Biology.
[2] Hua-Chuan Zhang,et al. Glycogen metabolism regulates macrophage-mediated acute inflammatory responses , 2020, Nature Communications.
[3] C. Slingluff,et al. Impaired enolase 1 glycolytic activity restrains effector functions of tumor-infiltrating CD8+ T cells , 2019, Science Immunology.
[4] W. Linehan,et al. Metabolic Labeling of Cultured Mammalian Cells for Stable Isotope-Resolved Metabolomics: Practical Aspects of Tissue Culture and Sample Extraction. , 2019, Methods in molecular biology.
[5] G. Gerosa. error bars , 2018 .
[6] H. Young,et al. Early TCR Signaling Induces Rapid Aerobic Glycolysis Enabling Distinct Acute T Cell Effector Functions , 2018, Cell reports.
[7] Xuetao Cao,et al. A Pck1-directed glycogen metabolic program regulates formation and maintenance of memory CD8+ T cells , 2017, Nature Cell Biology.
[8] Lanjuan Li,et al. Drp1-Dependent Mitochondrial Fission Plays Critical Roles in Physiological and Pathological Progresses in Mammals , 2017, International journal of molecular sciences.
[9] C. Leslie,et al. Aerobic glycolysis promotes T helper 1 cell differentiation through an epigenetic mechanism , 2016, Science.
[10] Y. Song,et al. Mitochondrial dynamics altered by oxidative stress in cancer , 2016, Free radical research.
[11] A. Lane,et al. Distinctly perturbed metabolic networks underlie differential tumor tissue damages induced by immune modulator β-glucan in a two-case ex vivo non-small-cell lung cancer study , 2016, Cold Spring Harbor molecular case studies.
[12] O. Kretz,et al. Mitochondrial Dynamics Controls T Cell Fate through Metabolic Programming , 2016, Cell.
[13] V. Boussiotis,et al. The role of metabolic reprogramming in T cell fate and function. , 2016, Current trends in immunology.
[14] Simon C Watkins,et al. The Tumor Microenvironment Represses T Cell Mitochondrial Biogenesis to Drive Intratumoral T Cell Metabolic Insufficiency and Dysfunction. , 2016, Immunity.
[15] D. Chan,et al. The mitochondrial fission receptor Mff selectively recruits oligomerized Drp1 , 2015, Molecular biology of the cell.
[16] J. Locasale,et al. Phosphoenolpyruvate Is a Metabolic Checkpoint of Anti-tumor T Cell Responses , 2015, Cell.
[17] R. Schreiber,et al. Metabolic Competition in the Tumor Microenvironment Is a Driver of Cancer Progression , 2015, Cell.
[18] Joshua D. Rabinowitz,et al. The return of metabolism: biochemistry and physiology of the pentose phosphate pathway , 2014, Biological reviews of the Cambridge Philosophical Society.
[19] M. Birnbaum,et al. Memory CD8(+) T cells use cell-intrinsic lipolysis to support the metabolic programming necessary for development. , 2014, Immunity.
[20] J. Rathmell,et al. The glucose transporter Glut1 is selectively essential for CD4 T cell activation and effector function. , 2014, Cell metabolism.
[21] Jae-Hoon Chang,et al. Inflammatory T cell responses rely on amino acid transporter ASCT2 facilitation of glutamine uptake and mTORC1 kinase activation. , 2014, Immunity.
[22] C. Ratledge. The role of malic enzyme as the provider of NADPH in oleaginous microorganisms: a reappraisal and unsolved problems , 2014, Biotechnology Letters.
[23] Chih-Hao Chang,et al. Fueling Immunity: Insights into Metabolism and Lymphocyte Function , 2013, Science.
[24] P. Muranski,et al. Inhibiting glycolytic metabolism enhances CD8+ T cell memory and antitumor function. , 2013, The Journal of clinical investigation.
[25] B. Faubert,et al. Posttranscriptional Control of T Cell Effector Function by Aerobic Glycolysis , 2013, Cell.
[26] Linda V. Sinclair,et al. Control of amino-acid transport by antigen receptors coordinates the metabolic reprogramming essential for T cell differentiation , 2013, Nature Immunology.
[27] S. Mehrotra,et al. Redox regulation of T-cell function: from molecular mechanisms to significance in human health and disease. , 2013, Antioxidants & redox signaling.
[28] J. Rathmell,et al. Metabolic regulation of T lymphocytes. , 2013, Annual review of immunology.
[29] J. Licht,et al. Mitochondria are required for antigen-specific T cell activation through reactive oxygen species signaling. , 2013, Immunity.
[30] R. Siegel,et al. Mitochondrial ROS fire up T cell activation. , 2013, Immunity.
[31] Linda V. Sinclair,et al. Antigen receptor control of amino acid transport coordinates the metabolic re-programming that is essential for T cell differentiation , 2013, Nature immunology.
[32] C. Ballantyne,et al. CD11a Regulates Effector CD8 T Cell Differentiation and Central Memory Development in Response to Infection with Listeria monocytogenes , 2013, Infection and Immunity.
[33] P. Grudnik,et al. T cell activation is driven by an ADP-dependent glucokinase linking enhanced glycolysis with mitochondrial reactive oxygen species generation. , 2012, Cell reports.
[34] P. Krammer,et al. Manganese superoxide dismutase: a regulator of T cell activation-induced oxidative signaling and cell death. , 2012, Biochimica et biophysica acta.
[35] J. Nunnari,et al. Mitochondria: In Sickness and in Health , 2012, Cell.
[36] T. Finkel. From Sulfenylation to Sulfhydration: What a Thiolate Needs to Tolerate , 2012, Science Signaling.
[37] G. V. D. van der Windt,et al. Mitochondrial respiratory capacity is a critical regulator of CD8+ T cell memory development. , 2012, Immunity.
[38] T. Fan,et al. High information throughput analysis of nucleotides and their isotopically enriched isotopologues by direct-infusion FTICR-MS , 2011, Metabolomics.
[39] Jesse M. Platt,et al. Hypoxia promotes isocitrate dehydrogenase-dependent carboxylation of α-ketoglutarate to citrate to support cell growth and viability , 2011, Proceedings of the National Academy of Sciences.
[40] Michael J Morgan,et al. Crosstalk of reactive oxygen species and NF-κB signaling , 2011, Cell Research.
[41] K. Frauwirth,et al. Glutamine Uptake and Metabolism Are Coordinately Regulated by ERK/MAPK during T Lymphocyte Activation , 2010, The Journal of Immunology.
[42] M. Veiga-da-Cunha,et al. Characterization of mammalian sedoheptulokinase and mechanism of formation of erythritol in sedoheptulokinase deficiency , 2008, FEBS letters.
[43] G. Perkins,et al. Mitochondrial fragmentation in neurodegeneration , 2008, Nature Reviews Neuroscience.
[44] J. Rathmell,et al. Glucose Uptake Is Limiting in T Cell Activation and Requires CD28-Mediated Akt-Dependent and Independent Pathways1 , 2008, The Journal of Immunology.
[45] C. Grant,et al. Metabolic reconfiguration is a regulated response to oxidative stress , 2008, Journal of biology.
[46] M. Ziegler,et al. NAD Kinase Levels Control the NADPH Concentration in Human Cells* , 2007, Journal of Biological Chemistry.
[47] D. Chan,et al. OPA1 processing controls mitochondrial fusion and is regulated by mRNA splicing, membrane potential, and Yme1L , 2007, The Journal of cell biology.
[48] F. Kauffman,et al. Metabolism via the pentose phosphate pathway in rat pheochromocytoma PC12 cells: Effects of nerve growth factor and 6-aminonicotinamide , 1987, Neurochemical Research.
[49] S. Rosenberg,et al. Tumor Regression and Autoimmunity after Reversal of a Functionally Tolerant State of Self-reactive CD8+ T Cells , 2003, The Journal of experimental medicine.
[50] N. Kruger,et al. The oxidative pentose phosphate pathway: structure and organisation. , 2003, Current opinion in plant biology.
[51] C. Thompson,et al. The CD28 signaling pathway regulates glucose metabolism. , 2002, Immunity.
[52] T. Huh,et al. Cytosolic NADP(+)-dependent isocitrate dehydrogenase status modulates oxidative damage to cells. , 2002, Free radical biology & medicine.
[53] Hao Shen,et al. Organ-Specific Regulation of the CD8 T Cell Response to Listeria monocytogenes Infection1 , 2001, The Journal of Immunology.
[54] M. Cascante,et al. Nonoxidative pentose phosphate pathways and their direct role in ribose synthesis in tumors: is cancer a disease of cellular glucose metabolism? , 1998, Medical hypotheses.
[55] R. D. Williams,et al. Oxythiamine and dehydroepiandrosterone inhibit the nonoxidative synthesis of ribose and tumor cell proliferation. , 1997, Cancer research.