Uni- and cross-modal temporal modulation of tactile extinction in right brain damaged patients

The influence of ipsilesional tactile and visual stimuli on the ability to detect contralesional tactile stimuli was investigated in eight right brain damaged patients (RBD) with tactile extinction and in eight healthy subjects by delivering a series of single and double stimuli. Double stimuli were unimodal (tactile or visual) or cross-modal (tactile and visual) and could be delivered simultaneously or sequentially at three possible intervals (65, 125, 305 ms). In sequential double trials, left-sided stimuli preceded or followed right-sided stimuli. Subjects were asked to verbally report number (1 or 2), side (left or right) and modality (tactile, visual, visuo-tactile). Control subjects were highly accurate in detecting single and double stimuli. RBD patients detected all right-sided stimuli and left single visual or tactile stimuli with high accuracy; however, they omitted left-sided tactile stimuli in a high proportion of double trials due to the presence of tactile extinction. Omissions of left-sided tactile stimuli were minimal at the longest SOA. Moreover, at 0 and 65 ms SOA omissions were significantly higher in unimodal than in cross-modal combinations. This figure indicates that detection of contralesional tactile stimuli is modulated over time both uni- and cross-modally.

[1]  A. Nobre,et al.  Orienting attention in time: behavioural and neuroanatomical distinction between exogenous and endogenous shifts , 2000, Neuropsychologia.

[2]  Chris Rorden,et al.  Non-spatially lateralized mechanisms in hemispatial neglect , 2003, Nature Reviews Neuroscience.

[3]  Nicola Smania,et al.  Frames of Reference for Mapping Tactile Stimuli in Brain-Damaged Patients , 1999, Journal of Cognitive Neuroscience.

[4]  A Maravita,et al.  Vision and touch through the looking glass in a case of crossmodal extinction , 2000, Neuroreport.

[5]  G Vallar,et al.  Anatomical correlates of visual and tactile extinction in humans: a clinical CT scan study. , 1994, Journal of neurology, neurosurgery, and psychiatry.

[6]  C. Gross,et al.  Coding of visual space by premotor neurons. , 1994, Science.

[7]  Macdonald Critchley,et al.  THE PHENOMENON OF TACTILE IN ATTENTION WITH SPECIAL REFERENCE TO PARIETAL LESIONS , 1949 .

[8]  A. Nobre,et al.  Multiple mechanisms of selective attention: differential modulation of stimulus processing by attention to space or time , 2002, Neuropsychologia.

[9]  G Rizzolatti,et al.  The Space Around Us , 1997, Science.

[10]  A W Inhoff,et al.  Bimodal extinction without cross-modal extinction. , 1992, Journal of neurology, neurosurgery, and psychiatry.

[11]  J. Gore,et al.  Neural Correlates of the Attentional Blink , 2000, Neuron.

[12]  C. Kennard,et al.  Abnormal temporal dynamics of visual attention in spatial neglect patients , 1997, Nature.

[13]  C. Spence,et al.  Visual Prior Entry , 2001, Psychological science.

[14]  Marlene Behrmann,et al.  Spatial and temporal influences on extinction , 2002, Neuropsychologia.

[15]  Kimron Shapiro,et al.  Direct measurement of attentional dwell time in human vision , 1994, Nature.

[16]  Jon Driver,et al.  Attentional competition between modalities: extinction between touch and vision after right hemisphere damage , 1997, Neuropsychologia.

[17]  G. Basso,et al.  Visual extinction as a spatio‐temporal disorder of selective attention , 1998, Neuroreport.

[18]  Elisabetta Làdavas,et al.  Seeing where your hands are , 1997, Nature.

[19]  Walter Schneider,et al.  Micro Experimental Laboratory: An integrated system for IBM PC compatibles , 1988 .

[20]  Francesco Pavani,et al.  Acoustical Vision of Neglected Stimuli: Interaction among Spatially Converging Audiovisual Inputs in Neglect Patients , 2002, Journal of Cognitive Neuroscience.

[21]  Jon Driver,et al.  Reaching with a tool extends visual–tactile interactions into far space: evidence from cross-modal extinction , 2001, Neuropsychologia.

[22]  E. Titchener.  Scientific Books: Lectures on the Elementary Psychology of Feeling and Attention , 1909 .

[23]  J. Dichgans,et al.  Space exploration in neglect. , 1998, Brain : a journal of neurology.

[24]  K L Shapiro,et al.  Temporary suppression of visual processing in an RSVP task: an attentional blink? . , 1992, Journal of experimental psychology. Human perception and performance.

[25]  H. Birch,et al.  Delayed information processing and extinction following cerebral damage. , 1967, Brain : a journal of neurology.

[26]  B. Eskenazi,et al.  The nature of unilateral neglect in the olfactory sensory system , 1988, Neuropsychologia.

[27]  Buccal hemineglect. , 2000, Archives of neurology.

[28]  S Ullman,et al.  Shifts in selective visual attention: towards the underlying neural circuitry. , 1985, Human neurobiology.

[29]  E. Renzi,et al.  Patterns of neglect dissociation. , 1989, Behavioural neurology.

[30]  C. Spence,et al.  Multisensory prior entry. , 2001, Journal of experimental psychology. General.

[31]  C. Bundesen.  A theory of visual attention. , 1990, Psychological review.

[32]  Alessandro Farnè,et al.  Auditory peripersonal space in humans. , 2002, Journal of cognitive neuroscience.

[33]  K. Shapiro,et al.  Attention to visual pattern information produces the attentional blink in rapid serial visual presentation. , 1994, Journal of experimental psychology. Human perception and performance.

[34]  V. Moro,et al.  Dissociation between taste and tactile extinction on the tongue after right brain damage , 2004, Neuropsychologia.

[35]  M S Graziano,et al.  A System of Multimodal Areas in the Primate Brain , 2001, Neuron.

[36]  M. Potter,et al.  A two-stage model for multiple target detection in rapid serial visual presentation. , 1995, Journal of experimental psychology. Human perception and performance.

[37]  Giuseppe di Pellegrino,et al.  Neuropsychological Evidence of an Integrated Visuotactile Representation of Peripersonal Space in Humans , 1998, Journal of Cognitive Neuroscience.

[38]  Giuseppe Di Pellegrino,et al.  Spatial extinction on double asynchronous stimulation , 1997, Neuropsychologia.

[39]  F. J. Friedrich,et al.  Effects of parietal injury on covert orienting of attention , 1984, The Journal of neuroscience : the official journal of the Society for Neuroscience.

[40]  J. Lewald,et al.  Impaired perception of temporal order in auditory extinction , 2002, Neuropsychologia.

[41]  S. Aglioti,et al.  Temporal Modulation of Spatial Tactile Extinction in Right-Brain-Damaged Patients , 2003, Journal of Cognitive Neuroscience.

[42]  Jane E. Raymond,et al.  Attention to visual pattern information produces the attentional blink in rapid serial visual presentation , 1994 .

[43]  V. Moro,et al.  Overt and covert processing of left-side information in unilateral neglect investigated with chimeric drawings. , 1996, Journal of clinical and experimental neuropsychology.

[44]  W. B. Pillsbury.  Lectures or the Elementary Psychology of Feeling and Attention , 1909 .

[45]  Jon Driver,et al.  Crossmodal attention , 1998, Current Opinion in Neurobiology.

[46]  C. A. Marzi,et al.  Input and Response Determinants of Visual Extinction: A Case Study , 1996, Cortex.