The COX‐2 inhibitors, meloxicam and nimesulide, suppress neurogenesis in the adult mouse brain

Background and purpose:  In adults, neurogenesis persists in the hippocampus and the subventricular zone (SVZ), and this is important for learning and memory. Inhibitors of COX‐2 suppress ischaemia‐induced neurogenesis in the hippocampus. Here, we have determined the effects of COX‐2 inhibitors on neurogenesis throughout the normal adult mouse brain.

[1]  P. Lipsky.  Introduction. The role of COX-2-specific inhibitors in clinical practice. , 2001, The American journal of medicine.

[2]  O. Lindvall,et al.  Inflammation is detrimental for neurogenesis in adult brain , 2003, Proceedings of the National Academy of Sciences of the United States of America.

[3]  H. Berendse,et al.  Subclinical dopaminergic dysfunction in asymptomatic Parkinson's disease patients' relatives with a decreased sense of smell , 2001, Annals of neurology.

[4]  Maria B. Luskin,et al.  Restricted proliferation and migration of postnatally generated neurons derived from the forebrain subventricular zone , 1993, Neuron.

[5]  Carol A. Barnes,et al.  Expression of a mitogen-inducible cyclooxygenase in brain neurons: Regulation by synaptic activity and glucocorticoids , 1993, Neuron.

[6]  L. Bonfanti,et al.  Expression of polysialylated neural cell adhesion molecule by proliferating cells in the subependymal layer of the adult rat, in its rostral extension and in the olfactory bulb , 1994, Neuroscience.

[7]  H. Scharfman,et al.  Neuroscience. Is more neurogenesis always better? , 2007, Science.

[8]  C. Deng,et al.  Fibroblast Growth Factor Receptor-1 is Required for Long-Term Potentiation, Memory Consolidation, and Neurogenesis , 2007, Biological Psychiatry.

[9]  Deanna L. Taylor,et al.  Microglia release activators of neuronal proliferation mediated by activation of mitogen‐activated protein kinase, phosphatidylinositol‐3‐kinase/Akt and delta–Notch signalling cascades , 2004, Journal of neurochemistry.

[10]  F. Gage,et al.  Neuroscience. Cellular interactions in the stem cell niche. , 2004, Science.

[11]  Christelle Rochefort,et al.  Enriched Odor Exposure Increases the Number of Newborn Neurons in the Adult Olfactory Bulb and Improves Odor Memory , 2002, The Journal of Neuroscience.

[12]  M. Ross,et al.  Cyclo-Oxygenase-2 Gene Expression in Neurons Contributes to Ischemic Brain Damage , 1997, The Journal of Neuroscience.

[13]  D. Steindler,et al.  Microglia instruct subventricular zone neurogenesis , 2006, Glia.

[14]  N. Bazan.  COX-2 as a multifunctional neuronal modulator , 2001, Nature Medicine.

[15]  G. Kempermann.  They Are Not Too Excited: The Possible Role of Adult-Born Neurons in Epilepsy , 2006, Neuron.

[16]  A. Álvarez-Buylla,et al.  For the Long Run Maintaining Germinal Niches in the Adult Brain , 2004, Neuron.

[17]  Arturo Alvarez-Buylla,et al.  EGF Converts Transit-Amplifying Neurogenic Precursors in the Adult Brain into Multipotent Stem Cells , 2002, Neuron.

[18]  D. Türck,et al.  A review of the clinical pharmacokinetics of meloxicam. , 1996, British journal of rheumatology.

[19]  J. García-Verdugo,et al.  Cellular Composition and Three-Dimensional Organization of the Subventricular Germinal Zone in the Adult Mammalian Brain , 1997, The Journal of Neuroscience.

[20]  H. T. Ghashghaei,et al.  Reinduction of ErbB2 in astrocytes promotes radial glial progenitor identity in adult cerebral cortex. , 2007, Genes & development.

[21]  R. N. Brogden,et al.  Nimesulide. An update of its pharmacodynamic and pharmacokinetic properties, and therapeutic efficacy. , 1994, Drugs.

[22]  Yaniv Ziv,et al.  Immune cells contribute to the maintenance of neurogenesis and spatial learning abilities in adulthood , 2006, Nature Neuroscience.

[23]  A. Parent,et al.  Bcl-2 Protein as a Marker of Neuronal Immaturity in Postnatal Primate Brain , 1998, The Journal of Neuroscience.

[24]  P. Worley,et al.  COX-2, a synaptically induced enzyme, is expressed by excitatory neurons at postsynaptic sites in rat cerebral cortex. , 1996, Proceedings of the National Academy of Sciences of the United States of America.

[25]  D. Brown,et al.  Which proliferation markers for routine immunohistology? A comparison of five antibodies. , 1994, Journal of clinical pathology.

[26]  F. Gage,et al.  Neurogenesis in the adult human hippocampus , 1998, Nature Medicine.

[27]  H. Scharfman,et al.  Is More Neurogenesis Always Better? , 2007, Science.

[28]  T. Shono,et al.  Cyclooxygenase-2 expression in human gliomas: prognostic significance and molecular correlations. , 2001, Cancer research.

[29]  H. Budka,et al.  Cyclooxygenase-2 is induced in microglia during chronic cerebral ischemia in humans , 2000, Acta Neuropathologica.

[30]  O. Lindvall,et al.  Neuronal replacement from endogenous precursors in the adult brain after stroke , 2002, Nature Medicine.

[31]  Adi Mizrahi,et al.  Dendritic development and plasticity of adult-born neurons in the mouse olfactory bulb , 2007, Nature Neuroscience.

[32]  J. Haxby,et al.  OLFACTORY DETECTION AND RECOGNITION IN ALZHEIMER'S DISEASE , 1987, The Lancet.

[33]  F. Gage,et al.  Epidermal Growth Factor and Fibroblast Growth Factor-2 Have Different Effects on Neural Progenitors in the Adult Rat Brain , 1997, The Journal of Neuroscience.

[34]  Keun-Hwa Jung,et al.  Cyclooxygenase-2 inhibitor, celecoxib, inhibits the altered hippocampal neurogenesis with attenuation of spontaneous recurrent seizures following pilocarpine-induced status epilepticus , 2006, Neurobiology of Disease.

[35]  Austin G Smith,et al.  Niche-Independent Symmetrical Self-Renewal of a Mammalian Tissue Stem Cell , 2005, PLoS biology.

[36]  R. Hen,et al.  Requirement of Hippocampal Neurogenesis for the Behavioral Effects of Antidepressants , 2003, Science.

[37]  Constance M. Smith,et al.  The Division of Neuronal Progenitor Cells during Migration in the Neonatal Mammalian Forebrain , 1995, Molecular and Cellular Neuroscience.

[38]  T. Machida,et al.  Acetylsalicylic acid reduces ischemia-induced proliferation of dentate cells in gerbils , 2001, Neuroreport.

[39]  F. Gage,et al.  Neurogenic niche modulation by activated microglia: transforming growth factor β increases neurogenesis in the adult dentate gyrus , 2006, The European journal of neuroscience.

[40]  M. Serby,et al.  The nature and course of olfactory deficits in Alzheimer's disease. , 1991, The American journal of psychiatry.

[41]  P. Moberg,et al.  Olfaction in neurodegenerative disease: a meta-analysis of olfactory functioning in Alzheimer's and Parkinson's diseases. , 1998, Archives of neurology.

[42]  Michael J Thun,et al.  Nonsteroidal anti-inflammatory drugs as anticancer agents: mechanistic, pharmacologic, and clinical issues. , 2002, Journal of the National Cancer Institute.

[43]  F. Gage,et al.  Functional neurogenesis in the adult hippocampus , 2002, Nature.

[44]  Rafael J. Yáñez-Muñoz,et al.  A diacylglycerol lipase-CB2 cannabinoid pathway regulates adult subventricular zone neurogenesis in an age-dependent manner , 2008, Molecular and Cellular Neuroscience.

[45]  F. Gage,et al.  Mechanisms and Functional Implications of Adult Neurogenesis , 2008, Cell.

[46]  S. Haeberlein,et al.  Migration and differentiation of neural precursor cells can be directed by microglia , 2003, Proceedings of the National Academy of Sciences of the United States of America.

[47]  K. Jin,et al.  Neurogenesis and aging: FGF‐2 and HB‐EGF restore neurogenesis in hippocampus and subventricular zone of aged mice , 2003, Aging cell.

[48]  Jack M Parent,et al.  Rat forebrain neurogenesis and striatal neuron replacement after focal stroke , 2002, Annals of neurology.

[49]  Austin G Smith,et al.  Adherent neural stem (NS) cells from fetal and adult forebrain. , 2006, Cerebral cortex.

[50]  F. Gage,et al.  Cellular Interactions in the Stem Cell Niche , 2004, Science.

[51]  Colm Cunningham,et al.  The impact of systemic infection on the progression of neurodegenerative disease , 2003, Nature Reviews Neuroscience.

[52]  B. Hinz,et al.  Drug Insight: cyclo-oxygenase-2 inhibitors—a critical appraisal , 2007, Nature Clinical Practice Rheumatology.

[53]  Sally Temple,et al.  Endothelial Cells Stimulate Self-Renewal and Expand Neurogenesis of Neural Stem Cells , 2004, Science.

[54]  H. Okano,et al.  Implication of cyclooxygenase‐2 on enhanced proliferation of neural progenitor cells in the adult mouse hippocampus after ischemia , 2003, Journal of neuroscience research.

[55]  Yaniv Ziv,et al.  Microglia activated by IL-4 or IFN-γ differentially induce neurogenesis and oligodendrogenesis from adult stem/progenitor cells , 2006, Molecular and Cellular Neuroscience.

[56]  Richard L. Doty,et al.  Presence of both odor identification and detection deficits in alzheimer's disease , 1987, Brain Research Bulletin.

[57]  K. Hirata,et al.  Expression of Iba1 protein in microglial cells of zitter mutant rat , 2007, Neuroscience Letters.

[58]  Lan Xiao,et al.  Cannabinoids promote embryonic and adult hippocampus neurogenesis and produce anxiolytic- and antidepressant-like effects. , 2005, Journal of Clinical Investigation.