Toxicity of lithium to humans and the environment--a literature review.

Lithium concentrations in the surface and underground waters may be higher than general environment in places where lithium-rich brines and minerals occur, and in places where lithium batteries are disposed of. This review has indicated that lithium is not expected to bioaccumulate and its human and environmental toxicity are low. Lithium is not a dietary mineral for plants but it does stimulate plant growth. Large doses of lithium (up to 10 mg/L in serum) are given to patients with bipolar disorder. At 10 mg/L of blood, a person is mildly lithium poisoned. At 15 mg/L they experience confusion and speech impairment, and at 20 mg/L Li there is a risk of death. A provisional recommended daily intake of 14.3 microg/kg body weight lithium for an adult has been suggested.

[1]  N. J. Birch Possible mechanism for biological action of lithium , 1976, Nature.

[2]  M. Anke,et al.  Elements and their compounds in the environment , 2004 .

[3]  J. Chmielnicka,et al.  The trace elements in response to lithium intoxication in renal failure. , 2003, Ecotoxicology and environmental safety.

[4]  G. Schrauzer Lithium: Occurrence, Dietary Intakes, Nutritional Essentiality , 2002, Journal of the American College of Nutrition.

[5]  G. Rosen MUTATIONS INDUCED BY THE ACTION OF METAL IONS IN PISUM , 2010 .

[6]  B. Källén,et al.  Lithium and pregnancy , 1983 .

[7]  J. Poulsen,et al.  Studies on the haematologic and cytogenetic effect of lithium. , 2009, Acta medica Scandinavica.

[8]  G. Obe,et al.  Is Lithium Mutagenic in Man? , 1980, Pharmakopsychiatrie, Neuro-Psychopharmakologie.

[9]  Sack Rb Letter: Serotyping of E. coli. , 1976, Lancet.

[10]  A. Amdisen Clinical Features and Management of Lithium Poisoning , 1988, Medical toxicology and adverse drug experience.

[11]  K. H. Wedepohl,et al.  The Composition of the Continental Crust , 1995 .

[12]  H. Nishioka Mutagenic activities of metal compounds in bacteria. , 1975, Mutation research.

[13]  F. Oehme Toxicity of heavy metals in the environment , 1978 .

[14]  J. Timson,et al.  Lithium and mitosis. , 1971, Lancet.

[15]  D. Dhawan,et al.  Effect of lithium on hepatic lipid peroxidation and antioxidative enzymes under different dietary protein regimens , 1998, Journal of applied toxicology : JAT.

[16]  S J Hamilton,et al.  Hazard assessment of inorganics to three endangered fish in the Green River, Utah. , 1995, Ecotoxicology and environmental safety.

[17]  Fathi Habashi,et al.  Handbook of extractive metallurgy , 1997 .

[18]  J. Gazet,et al.  Letter: Treatment of Hodgkin's disease. , 1974, Lancet.

[19]  Helmut Sigel,et al.  Handbook on toxicity of inorganic compounds , 1990 .

[20]  A. Czeizel Budapest Registry of Self-poisoned Patients. , 1994, Mutation research.

[21]  A. Leonard,et al.  Mutagenicity, carcinogenicity and teratogenicity of lithium compounds. , 1995, Mutation research.

[22]  C. Phiel,et al.  Molecular targets of lithium action. , 2003, Annual review of pharmacology and toxicology.

[23]  John Doull,et al.  VIRAL DISEASES: A SYMPOSIUM , 1976, The Ulster Medical Journal.

[24]  U. Friedrich,et al.  Lithium and chromosome abnormalities. , 1969, Lancet.

[25]  S. Kulesza,et al.  [Lithium in biology and medicine]. , 1977, Postepy higieny i medycyny doswiadczalnej.

[26]  J. Edmond,et al.  Lithium and its isotopes in major world rivers: Implications for weathering and the oceanic budget , 1998 .

[27]  J. Moore,et al.  An assessment of lithium using the IEHR Evaluative Process for Assessing Human Developmental and Reproductive Toxicity of Agents. IEHR Expert Scientific Committee. , 1995, Reproductive toxicology.

[28]  G. Schrauzer,et al.  Lithium in drinking water and the incidences of crimes, suicides, and arrests related to drug addictions , 1990, Biological Trace Element Research.

[29]  A. J. Stewart,et al.  Review of Lithium in the Aquatic Environment: Distribution in the United States, Toxicity and Case Example of Groundwater Contamination , 2003, Ecotoxicology.

[30]  Humphrey John Moule Bowen,et al.  Environmental chemistry of the elements , 1979 .

[31]  L. Jarvik,et al.  Chromosome examinations in patients on lithium carbonate. , 1971, Archives of general psychiatry.

[32]  L. Price,et al.  Lithium in the treatment of mood disorders. , 1994, The New England journal of medicine.

[33]  M. Schou Lithium in psychiatric therapy and prophylaxis. , 1968, Journal of psychiatric research.

[34]  R. Torre,et al.  The in vivo and in vitro effects of lithium on human chromosomes and cell replication , 1976 .

[35]  A. Sadosty,et al.  The use of lithium levels in the emergency department. , 1999, The Journal of emergency medicine.

[36]  H. Manji,et al.  Long‐term action of lithium: A role for transcriptional and posttranscriptional factors regulated by protein kinase C , 1994, Synapse.

[37]  F. Vincent,et al.  Lithium in the treatment of mood disorders. , 1995 .

[38]  I. Kuznetsov,et al.  [Effect of alkaline metal ions on DNA secondary structure. IV. Thermal denaturation of alkaline metal deoxyribonucleates in solutions of low ionic strength]. , 1971, Biofizika.

[39]  B. Mason Principles of geochemistry , 1958 .

[40]  M. Freeman,et al.  Lithium: clinical considerations in internal medicine. , 2006, The American journal of medicine.

[41]  J. Domingo Metal-induced developmental toxicity in mammals: a review. , 1994, Journal of toxicology and environmental health.

[42]  A. J. Stewart,et al.  Toxicity of Lithium to Three Freshwater Organisms and the Antagonistic Effect of Sodium , 2003, Ecotoxicology.

[43]  A. Villeneuve,et al.  Lithium, chromosomes, and mitotic index. , 1971, Lancet.

[44]  Douglas Borys,et al.  2003 annual report of the American Association of Poison Control Centers Toxic Exposure Surveillance System. , 2004, The American journal of emergency medicine.

[45]  T. Einarson,et al.  A case-control study on the association between first trimester exposure to lithium and Ebstein's anomaly. , 1990, The American journal of cardiology.

[46]  Jefferson Jw,et al.  The checkered history of lithium in medicine. , 1980 .

[47]  B. Källén Comments on teratogen update: lithium , 1988 .

[48]  T. Inubushi,et al.  Lithium side effects in relation to brain lithium concentration measured by lithium-7 magnetic resonance spectroscopy , 1996, Progress in Neuro-Psychopharmacology and Biological Psychiatry.

[49]  T. Nagao,et al.  Effect of lithium on rat embryos in culture: Growth, development, compartmental distribution and lack of a protective effect of inositol , 2005, Archives of Toxicology.

[50]  G. Greenberg,et al.  Drugs in Pregnancy and Lactation , 1990 .

[51]  A. H. Cook The chemistry and biology of yeasts. , 1959 .

[52]  E. Tyobeka,et al.  Lithium enhances the proliferation of HL-60 promyelocytic leukemia cells. , 1990, Leukemia research.

[53]  A. Morávková,et al.  Results of genotoxicity testing of mazindol (degonan), lithium carbonicum (contemnol) and dropropizine (ditustat) in Chinese hamster V79 and human EUE cells. , 1986, Mutation research.

[54]  S. R. Rose,et al.  2002 annual report of the American Association of Poison Control Centers Toxic Exposure Surveillance System. , 2003, The American journal of emergency medicine.

[55]  A. Amdisen,et al.  Lithium teratogenicity. , 1971, Lancet.

[56]  Cathleen Clancy,et al.  Medical toxicology: Diagnosis and treatment of human poisoning , 1995 .

[57]  E. D. Wachsmuth,et al.  Effect of Amitosis on the Distribution of Human Lactic Acid Dehydrogenase Isozymes , 1964, Nature.

[58]  E. Gocke,et al.  Mutagenicity studies with x-ray-contrast media, analgesics, antipyretics, antirheumatics and some other pharmaceutical drugs in bacterial, Drosophila and mammalian test systems. , 1979, Mutation research.

[59]  T. Litovitz,et al.  1994 annual report of the American Association of Poison Control Centers Toxic Exposure Surveillance System. , 1995, The American journal of emergency medicine.

[60]  S. Moores Between a rock and a salt lake , 2007 .

[61]  T. Terao,et al.  Lithium and dementia: A preliminary study , 2006, Progress in Neuro-Psychopharmacology and Biological Psychiatry.

[62]  Takehiko Tsuruta,et al.  Removal and recovery of lithium using various microorganisms. , 2005, Journal of bioscience and bioengineering.

[63]  Lithium salts in the treatment of psychotic excitement. , 1949, The Medical journal of Australia.

[64]  R. Sram,et al.  Inhibition of DNA repair synthesis in the rat by in vivo exposure to psychotropic drugs and reversal of the effect by co-administration with alpha-tocopherol. , 1990, Mutation research.

[65]  J. Bannigan,et al.  The effects of lithium on neurulation stage mouse embryos , 1997, Archives of Toxicology.

[66]  P. K. Dixit,et al.  Teratogenic effects of lithium in mice. , 1982, Teratology.

[67]  Prospective multicentre study of pregnancy outcome after lithium exposure during first trimester , 1992, The Lancet.

[68]  黄亚明 eMedicine , 2009 .

[69]  R. Stern Lithium in the treatment of mood disorders. , 1995, The New England journal of medicine.

[70]  N. Kanematsu,et al.  Rec assay and mutagenicity studies on metal compounds. , 1980, Mutation research.