Plasma urea kinetics in urea infusion

Seven patients undergoing an infusion of 30 per cent urea‐10 per cent invert sugar solution (Urevert) for treatment of cerebral edema were studied with regard to plasma urea kinetics. The 2 compartment (extracellular and intracellular fluid spaces) model has been applied to analysis of the plasma levels. On the average, the human data could be simulated with our standard canine correlation: 2 compartment urea transport coefficient K, (liters per hour)= 0.735 weight (kilograms)± 14 per cent.