EZH2 Mediates epigenetic silencing of neuroblastoma suppressor genes CASZ1, CLU, RUNX3, and NGFR.
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J. Khan | Jun S. Wei | S. Bates | C. Thiele | Chunxi Wang | Chan-Wook Woo | Zhijie Li | Zhihui Liu | V. Marquez | K. Ge | Qihuang Jin | Lifeng Wang
[1] J. Khan,et al. CASZ1, a candidate tumor-suppressor gene, suppresses neuroblastoma tumor growth through reprogramming gene expression , 2011, Cell Death and Differentiation.
[2] Lu Gan,et al. Cyclin-dependent kinases regulate epigenetic gene silencing through phosphorylation of EZH2 , 2010, Nature Cell Biology.
[3] Guy Sauvageau,et al. Polycomb group proteins: multi-faceted regulators of somatic stem cells and cancer. , 2010, Cell stem cell.
[4] L. Boyer,et al. Polycomb group proteins set the stage for early lineage commitment. , 2010, Cell stem cell.
[5] Ji-Eun Lee,et al. Histone H3K27 methyltransferase Ezh2 represses Wnt genes to facilitate adipogenesis , 2010, Proceedings of the National Academy of Sciences.
[6] Nicolò Riggi,et al. EZH2 is essential for glioblastoma cancer stem cell maintenance. , 2009, Cancer research.
[7] Kristian Helin,et al. Polycomb group proteins: navigators of lineage pathways led astray in cancer , 2009, Nature Reviews Cancer.
[8] Huidong Shi,et al. Combined epigenetic therapy with the histone methyltransferase EZH2 inhibitor 3-deazaneplanocin A and the histone deacetylase inhibitor panobinostat against human AML cells. , 2009, Blood.
[9] F. Westermann,et al. Molecular characterization and classification of neuroblastoma. , 2009, Future oncology.
[10] N. Sebire,et al. Clusterin, a haploinsufficient tumor suppressor gene in neuroblastomas. , 2009, Journal of the National Cancer Institute.
[11] G. Hannon,et al. Ezh2 Orchestrates Gene Expression for the Stepwise Differentiation of Tissue-Specific Stem Cells , 2009, Cell.
[12] H. Kovar,et al. EZH2 is a mediator of EWS/FLI1 driven tumor growth and metastasis blocking endothelial and neuro-ectodermal differentiation , 2009, Proceedings of the National Academy of Sciences.
[13] S. Varambally,et al. Genomic Loss of microRNA-101 Leads to Overexpression of Histone Methyltransferase EZH2 in Cancer , 2008, Science.
[14] S. Dhanasekaran,et al. Repression of E-cadherin by the polycomb group protein EZH2 in cancer , 2008, Oncogene.
[15] J. Pollack,et al. MYC stimulates EZH2 expression by repression of its negative regulator miR-26a. , 2008, Blood.
[16] Stefano Bonassi,et al. Identification of low intratumoral gene expression heterogeneity in neuroblastic tumors by genome‐wide expression analysis and game theory , 2008, Cancer.
[17] J Khan,et al. The MYCN oncogene is a direct target of miR-34a , 2008, Oncogene.
[18] J. Maris,et al. CHD5, a Tumor Suppressor Gene Deleted From 1p36.31 in Neuroblastomas , 2008, Journal of the National Cancer Institute.
[19] Yuri Kotliarov,et al. Epigenetic-mediated dysfunction of the bone morphogenetic protein pathway inhibits differentiation of glioblastoma-initiating cells. , 2008, Cancer cell.
[20] T. Veenstra,et al. Identification of JmjC domain-containing UTX and JMJD3 as histone H3 lysine 27 demethylases , 2007, Proceedings of the National Academy of Sciences.
[21] D. Ghosh,et al. A polycomb repression signature in metastatic prostate cancer predicts cancer outcome. , 2007, Cancer research.
[22] H. Carén,et al. Genetic and epigenetic changes in the common 1p36 deletion in neuroblastoma tumours , 2007, British Journal of Cancer.
[23] J. Mchugh,et al. Expression of polycomb group protein EZH2 in nevi and melanoma , 2007, Journal of cutaneous pathology.
[24] Qiang Yu,et al. Pharmacologic disruption of Polycomb-repressive complex 2-mediated gene repression selectively induces apoptosis in cancer cells. , 2007, Genes & development.
[25] Kristian Helin,et al. The Polycomb group proteins bind throughout the INK4A-ARF locus and are disassociated in senescent cells. , 2007, Genes & development.
[26] H. Vogel,et al. CHD5 Is a Tumor Suppressor at Human 1p36 , 2007, Cell.
[27] Tommy Martinsson,et al. Neuroblastoma tumors with favorable and unfavorable outcomes: Significant differences in mRNA expression of genes mapped at 1p36.2 , 2007, Genes, chromosomes & cancer.
[28] C. Thiele,et al. Molecular cloning and characterization of human Castor, a novel human gene upregulated during cell differentiation. , 2006, Biochemical and biophysical research communications.
[29] James A. Cuff,et al. A Bivalent Chromatin Structure Marks Key Developmental Genes in Embryonic Stem Cells , 2006, Cell.
[30] O. Halvorsen,et al. EZH2 expression is associated with high proliferation rate and aggressive tumor subgroups in cutaneous melanoma and cancers of the endometrium, prostate, and breast. , 2006, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.
[31] P. Houghton,et al. Evaluation of the Antitumor Efficacy, Pharmacokinetics, and Pharmacodynamics of the Histone Deacetylase Inhibitor Depsipeptide in Childhood Cancer Models In vivo , 2006, Clinical Cancer Research.
[32] E. Connolly,et al. Chromosome 1p and 11q Deletions and Outcome in Neuroblastoma. , 2006, Neurosurgery.
[33] J. Khan,et al. Altered expression of cell cycle genes distinguishes aggressive neuroblastoma , 2005, Oncogene.
[34] Takeshi Inoue,et al. Marker genes to predict sensitivity to FK228, a histone deacetylase inhibitor. , 2005, Biochemical pharmacology.
[35] L. Hesson,et al. A cluster of genes located in 1p36 are down-regulated in neuroblastomas with poor prognosis, but not due to CpG island methylation , 2005, Molecular Cancer.
[36] G. Melino,et al. Mechanism of Induction of Apoptosis by p73 and Its Relevance to Neuroblastoma Biology , 2004, Annals of the New York Academy of Sciences.
[37] Qing-Rong Chen,et al. Prediction of Clinical Outcome Using Gene Expression Profiling and Artificial Neural Networks for Patients with Neuroblastoma , 2004, Cancer Research.
[38] G. Chatta. Multiplex biomarker approach for determining risk of prostate-specific antigen-defined recurrence of prostate cancer , 2003 .
[39] Kristian Helin,et al. EZH2 is downstream of the pRB‐E2F pathway, essential for proliferation and amplified in cancer , 2003, The EMBO journal.
[40] Debashis Ghosh,et al. EZH2 is a marker of aggressive breast cancer and promotes neoplastic transformation of breast epithelial cells , 2003, Proceedings of the National Academy of Sciences of the United States of America.
[41] Arul M Chinnaiyan,et al. Multiplex biomarker approach for determining risk of prostate-specific antigen-defined recurrence of prostate cancer. , 2003, Journal of the National Cancer Institute.
[42] Rogier Versteeg,et al. Rearrangements and increased expression of cyclin D1 (CCND1) in neuroblastoma , 2003, Genes, chromosomes & cancer.
[43] G. Brodeur. Neuroblastoma: biological insights into a clinical enigma , 2003, Nature Reviews Cancer.
[44] R. Stallings,et al. Are gains of chromosomal regions 7q and 11p important abnormalities in neuroblastoma? , 2003, Cancer genetics and cytogenetics.
[45] S. Dhanasekaran,et al. The polycomb group protein EZH2 is involved in progression of prostate cancer , 2002, Nature.
[46] Hengbin Wang,et al. Role of Histone H3 Lysine 27 Methylation in Polycomb-Group Silencing , 2002, Science.
[47] S. Itohara,et al. Causal Relationship between the Loss of RUNX3 Expression and Gastric Cancer , 2002, Cell.
[48] C. Eng,et al. RASSF1A promoter region CpG island hypermethylation in phaeochromocytomas and neuroblastoma tumours , 2001, Oncogene.
[49] Rogier Versteeg,et al. Allelic loss of chromosome 1p as a predictor of unfavorable outcome in patients with neuroblastoma. , 1996, The New England journal of medicine.
[50] C. Rieder,et al. Greatwall kinase , 2004, The Journal of cell biology.
[51] W. Odenwald,et al. castor encodes a novel zinc finger protein required for the development of a subset of CNS neurons in drosophila , 1992, Neuron.