Dementia in adults with mental retardation: assessment at a single point in time.

Dementia status of 273 adults with mental retardation was rated based upon two extensive evaluations conducted 18 months apart. Overall, 184 individuals did not have dementia, 33 had possible or definite dementia, and 66 had findings suggesting uncertain or questionable status. These ratings were compared to binary classifications (dementia vs. no dementia) generated from the Dementia Questionnaire for Persons With Mental Retardation (Evenhuis, 1995) and the IBR Mental Status Examination (Wisniewski & Hill, 1985). When performance was referenced to IQs (established earlier in adulthood), quantitative criteria effectively distinguished between individuals with and without dementia based upon assessment at a single point in time. Findings suggest that procedures of this type could soon contribute to more accurate and rapid diagnoses of dementia.

[1]  S. Folstein,et al.  "Mini-mental state". A practical method for grading the cognitive state of patients for the clinician. , 1975, Journal of psychiatric research.

[2]  J. Haxby.  Neuropsychological evaluation of adults with Down's syndrome: patterns of selective impairment in non-demented old adults. , 2008, Journal of mental deficiency research.

[3]  E. Aylward,et al.  Diagnosis of dementia in individuals with intellectual disability. , 1997, Journal of intellectual disability research : JIDR.

[4]  H. Wiśniewski,et al.  Aging and Alzheimer's disease in Down syndrome: Clinical and pathological changes , 1996 .

[5]  M. Roth,et al.  The Association Between Quantitative Measures of Dementia and of Senile Change in the Cerebral Grey Matter of Elderly Subjects , 1968, British Journal of Psychiatry.

[6]  H. Wiśniewski,et al.  Aging and Dementia among Adults with Mental Retardation and Down Syndrome , 1998 .

[7]  J. Haxby,et al.  NIH conference. Alzheimer disease: clinical and biological heterogeneity. , 1988, Annals of internal medicine.

[8]  N. Schupf,et al.  Prevalence of dementia in adults with and without Down syndrome. , 1996, American journal of mental retardation : AJMR.

[9]  M. A. Merrill,et al.  Stanford-Binet Intelligence Scale , 1972 .

[10]  B. Reisberg,et al.  Dementia: a systematic approach to identifying reversible causes. , 1986, Geriatrics.

[11]  S H Ferris,et al.  Diagnosis and treatment of Alzheimer disease and related disorders. Consensus statement of the American Association for Geriatric Psychiatry, the Alzheimer's Association, and the American Geriatrics Society. , 1997, JAMA.

[12]  V. Prasher,et al.  Dementia Questionnaire for Persons with Mental Retardation (DMR): Modified Criteria for Adults with Down's Syndrome , 1997 .

[13]  S. Krinsky-McHale,et al.  Changes in explicit memory associated with early dementia in adults with Down's syndrome. , 2002, Journal of intellectual disability research : JIDR.

[14]  Herman Buschke,et al.  Selective reminding for analysis of memory and learning , 1973 .

[15]  M. Albert,et al.  The Test for Severe Impairment: An Instrument for the Assessment of Patients with Severe Cognitive Dysfunction , 1992, Journal of the American Geriatrics Society.

[16]  P. Truax,et al.  Assessment of behavioral problems in dementia: the revised memory and behavior problems checklist. , 1992, Psychology and aging.

[17]  H. Wiśniewski,et al.  Aging and developmental disabilities : issues and approaches , 1985 .

[18]  Robert L. Schalock,et al.  Mental Retardation: Definition, Classification, and Systems of Supports. 10th Edition. , 2002 .

[19]  L. Igrić,et al.  AAMD Adaptive Behavior Scale , 1991 .

[20]  R. Katzman.,et al.  Early detection of senile dementia. , 1981, Hospital practice.

[21]  A. Dalton,et al.  Dementia, aging, and intellectual disabilities : a handbook , 1999 .

[22]  R. Eyman,et al.  Mortality of people with mental retardation in California with and without Down syndrome, 1986-1991. , 1996, American journal of mental retardation : AJMR.

[23]  Dc Washington.  Diagnostic and Statistical Manual of Mental Disorders, 4th Ed. , 1994 .

[24]  Stefano Cappa,et al.  Aging and dementia , 2001 .

[25]  L. Berg.  Clinical Dementia Rating (CDR). , 1988, Psychopharmacology bulletin.