Surface Modifications Technology of Quantum Dots Based Biosensors and Their Medical Applications

Abstract Quantum dots (QDs) as a new type of nano-structured luminescent materials has been widely used in biology, materials science, and physical optics. QD-based biosensors can be used for the rapid and accurate detection of biological macromolecules or inorganic molecules both in vivo and in vitro. To enhance their fluorescence properties and lower their biological toxicity, the surface of QDs needs to be modified. Currently, the surface modification technologies mainly include multidentate ligand, sulphydryl group coupling, amphiphilic molecules, cavity-chain, and dendrimer technology. Meanwhile, various biosensors have been developed by adopting different modification techniques to locate and track a variety of disease-specific biological molecules. Although enormous literatures have reported the biological applications of QD-based biosensors, few systematic reviews of surface modification technologies on QDs have been published. This paper reviews the surface modification technologies of QDs in biosensors and their medical applications.

[1]  Miguel Valcárcel,et al.  Colistin-functionalised CdSe/ZnS quantum dots as fluorescent probe for the rapid detection of Escherichia coli. , 2011, Biosensors & bioelectronics.

[2]  Shurong Tang,et al.  Ultrasensitive electrochemical detection of Pb²⁺ based on rolling circle amplification and quantum dots tagging. , 2013, Biosensors & bioelectronics.

[3]  Yunfei Liu,et al.  Using layer-by-layer assembly to fabricate NaLa(MoO4)2@CdTe core–shell microspheres with high fluorescence , 2014, Journal of Materials Science.

[4]  Xueming Li,et al.  A suspension-cell biosensor for real-time determination of binding kinetics of protein-carbohydrate interactions on cancer cell surfaces. , 2013, Chemical communications.

[5]  Daxiang Cui,et al.  HER2 monoclonal antibody conjugated RNase-A-associated CdTe quantum dots for targeted imaging and therapy of gastric cancer. , 2012, Biomaterials.

[6]  Vibha Rani,et al.  Nanotechnology: Emerging Tool for Diagnostics and Therapeutics , 2011, Applied biochemistry and biotechnology.

[7]  F. Raymo,et al.  A mechanism to signal receptor-substrate interactions with luminescent quantum dots. , 2006, Proceedings of the National Academy of Sciences of the United States of America.

[8]  T. Kissel,et al.  Amphiphilic biodegradable PEG-PCL-PEI triblock copolymers for FRET-capable in vitro and in vivo delivery of siRNA and quantum dots. , 2014, Molecular pharmaceutics.

[9]  M. S. Miranda,et al.  CdSe quantum dots capped PAMAM dendrimer nanocomposites for sensing nitroaromatic compounds. , 2011, Talanta.

[10]  M. S. Miranda,et al.  Thiolated DAB dendrimers and CdSe quantum dots nanocomposites for Cd(II) or Pb(II) sensing. , 2012, Talanta.

[11]  Jian Li,et al.  Luminescent properties of CdTe quantum dots synthesized using 3-mercaptopropionic acid reduction of tellurium dioxide directly , 2013, Nanoscale Research Letters.

[12]  M. R. Kim,et al.  Charge separation in Pt-decorated CdSe@CdS octapod nanocrystals. , 2014, Nanoscale.

[13]  M. Hosseini,et al.  Study of fluorescence quenching of mercaptosuccinic acid‐capped CdS quantum dots in the presence of some heavy metal ions and its application to Hg(II) ion determination , 2014 .

[14]  M. Bawendi,et al.  CdSe nanocrystal based chem-/bio- sensors. , 2007, Chemical Society reviews.

[15]  Xianggang Liu,et al.  Sensitivity and selectivity determination of BPA in real water samples using PAMAM dendrimer and CoTe quantum dots modified glassy carbon electrode. , 2010, Journal of hazardous materials.

[16]  Guanhong Xu,et al.  Citrate-capped Mn-modified CdSe/CdS quantum dots as luminescent probes for levodopa detection in aqueous solution. , 2012, Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy.

[17]  Christopher G. Khoury,et al.  Plasmonic nanoprobes: from chemical sensing to medical diagnostics and therapy. , 2013, Nanoscale.

[18]  Weiling Fu,et al.  Dual-aptamer-based biosensing of toxoplasma antibody. , 2013, Analytical chemistry.

[19]  S. Menon,et al.  Calixarene capped ZnS quantum dots as an optical nanoprobe for detection and determination of menadione. , 2012, The Analyst.

[20]  Xiwen He,et al.  Molecularly imprinted polymer anchored on the surface of denatured bovine serum albumin modified CdTe quantum dots as fluorescent artificial receptor for recognition of target protein. , 2012, Biosensors & bioelectronics.

[21]  Kai Chen,et al.  Hydrothermal synthesis, crystal structures and luminescent properties of two new carboxylate-dependent Cd(II)-guanazole (3,5-diamino-1,2,4-triazole) frameworks , 2013 .

[22]  Nokyoung Park,et al.  Metal ion-induced dual fluorescent change for aza-crown ether acridinedione-functionalized gold nanorods and quantum dots , 2012 .

[23]  D. Cordes,et al.  A unique, two-component sensing system for fluorescence detection of glucose and other carbohydrates , 2012 .

[24]  M. Fiałkowski,et al.  A "wrap-and-wrest" mechanism of fluorescence quenching of CdSe/ZnS quantum dots by surfactant molecules. , 2013, Nanoscale.

[25]  Shusheng Zhang,et al.  Versatile electrochemiluminescence assays for cancer cells based on dendrimer/CdSe-ZnS-quantum dot nanoclusters. , 2011, Analytical chemistry.

[26]  Baoxin Li,et al.  H(2) O(2) - and pH-sensitive CdTe quantum dots as fluorescence probes for the detection of glucose. , 2013, Luminescence : the journal of biological and chemical luminescence.

[27]  Hedi Mattoussi,et al.  Multidentate zwitterionic ligands provide compact and highly biocompatible quantum dots. , 2013, Journal of the American Chemical Society.

[28]  S. Bals,et al.  Tailoring ZnSe-CdSe colloidal quantum dots via cation exchange: from core/shell to alloy nanocrystals. , 2013, ACS nano.

[29]  Itamar Willner,et al.  Optical molecular sensing with semiconductor quantum dots (QDs). , 2012, Chemical Society reviews.

[30]  H. Ju,et al.  Electrochemiluminescence detection of near single DNA molecules by using quantum dots-dendrimer nanocomposites for signal amplification. , 2011, Chemical communications.

[31]  M. Entezari,et al.  Micro-emulsion under ultrasound facilitates the fast synthesis of quantum dots of CdS at low temperature. , 2011, Ultrasonics sonochemistry.

[32]  B. Parkinson,et al.  Controlling the electronic coupling between CdSe quantum dots and thiol capping ligands via pH and ligand selection. , 2012, Langmuir : the ACS journal of surfaces and colloids.

[33]  D. Pang,et al.  The cadmium–mercaptoacetic acid complex contributes to the genotoxicity of mercaptoacetic acid-coated CdSe-core quantum dots , 2012, International journal of nanomedicine.

[34]  Jiang Xia,et al.  Preferential binding of a novel polyhistidine peptide dendrimer ligand on quantum dots probed by capillary electrophoresis. , 2011, Analytical chemistry.

[35]  Raghavendra Kikkeri,et al.  Glyco-β-cyclodextrin capped quantum dots: synthesis, cytotoxicity and optical detection of carbohydrate-protein interactions. , 2012, The Analyst.

[36]  Shuo Diao,et al.  Biological imaging using nanoparticles of small organic molecules with fluorescence emission at wavelengths longer than 1000 nm. , 2013, Angewandte Chemie.

[37]  S. Nishimura,et al.  Importance of sialic acid residues illuminated by live animal imaging using phosphorylcholine self-assembled monolayer-coated quantum dots. , 2011, Journal of the American Chemical Society.

[38]  Valentina Marchesano,et al.  Mechanisms underlying toxicity induced by CdTe quantum dots determined in an invertebrate model organism. , 2012, Biomaterials.

[39]  S. Cosnier,et al.  Impedimetric biosensor for cancer cell detection , 2013 .

[40]  Weiling Fu,et al.  Sensitive and rapid quantification of C-reactive protein using quantum dot-labeled microplate immunoassay , 2011, Journal of Translational Medicine.

[41]  Xinxia Cai,et al.  Detection of Bacillus Anthracis Using Fluorescence Immunoassay with Quantum Dots Labels , 2011 .