Families at risk of colorectal cancer: who are they?

The first degree kinships of 305 index cases have been studied to determine whether an early age of onset or a particular site distribution characterizes familial aggregations of colorectal cancer. The probands comprised 100 patients aged 55-74 years and 205 patients under 55 years at diagnosis and were drawn from a large population database. Ascertainment and verification were complete for 2566 of 2657 first degree relatives. The history of cancer in 296 relatives was validated in 96% of cases from medical or other records. Among kinships ascertained through index cases under 55 years of age, less than 5% had three or more individuals affected by colorectal cancer. The comparable proportion of older probands' families was 3%. Probands with proximal disease were no more likely to have a positive family history of bowel cancer than those with disease distal to the splenic flexure. These findings are consistent with other population based studies of the epidemiology of familial colorectal cancer but contrast with reviews from referral centres and family cancer clinics.

[1]  J. Mecklin,et al.  Hereditary non-polyposis colorectal cancer , 1991, The Lancet.

[2]  F. Kee,et al.  How prevalent is cancer family syndrome? , 1991, Gut.

[3]  S. Bülow,et al.  Cancer incidence among parents of patients with colorectal cancer , 1991, International journal of cancer.

[4]  R. Houlston,et al.  Risk of cancer death in first‐degree relatives of patients with hereditary non‐polyposis cancer syndrome (Lynch type II): A study of 130 kindreds in the United Kingdom , 1990, The British journal of surgery.

[5]  H. Lynch,et al.  Abnormalities of lectin histochemistry in familial polyposis coli and hereditary nonpolyposis colorectal cancer , 1990, Cancer.

[6]  M. Skolnick,et al.  Characteristics of familial colon cancer in a large population data base , 1989, Cancer.

[7]  L. Roncucci,et al.  Familial aggregation of tumors in the three-year experience of a population-based colorectal cancer registry. , 1989, Cancer research.

[8]  E. Riboli,et al.  LATENT COLORECTAL CANCER FOUND AT NECROPSY , 1989, The Lancet.

[9]  G. Fisher,et al.  Familial colorectal cancer and the screening of family members , 1989, The Medical journal of Australia.

[10]  T. Smyrk,et al.  Differential diagnosis of hereditary nonpolyposis colorectal cancer (Lynch syndrome I and Lynch syndrome II) , 1988, Diseases of the colon and rectum.

[11]  P. Schulte,et al.  Methodologic issues in the use of biologic markers in epidemiologic research. , 1987, American journal of epidemiology.

[12]  J. Mecklin.  Frequency of hereditary colorectal carcinoma. , 1987, Gastroenterology.

[13]  R. Elston,et al.  Hereditary nonpolyposis colorectal cancer (lynch syndromes I and II). II. Biomarker studies , 1985, Cancer.

[14]  R. Chaganti,et al.  Familial predisposition to cancer and age at onset of disease in randomly selected cancer patients. , 1983, American journal of human genetics.

[15]  R. Quadrelli,et al.  [Familial colonic cancer]. , 1978, La Nouvelle presse medicale.

[16]  J. Geenen,et al.  Diabetic Diarrhea: A clinical and pathophysiological study , 1969 .

[17]  F. Kee,et al.  Histologic characteristics and outcome of familial non-polyposis colorectal carcinoma. , 1991, Scandinavian journal of gastroenterology.

[18]  A. Chakravarti,et al.  Estimating the age‐at‐onset function using life‐table methods , 1988, Genetic epidemiology.

[19]  R. Elston,et al.  Segregation analysis of hereditary nonpolyposis colorectal cancer , 1986, Genetic epidemiology.