Identification of a New Structural Variant of Human Apolipoprotein E , E 2 ( Lys , 46 , Gln ) , in a Type III Hyperlipoproteinemic Subject with the E 3 / 2 Phenotype

Address all correspondence to Dr. R. W. Mahley, The Gladstone Foundation Laboratories, P. 0. Box 40608, San Francisco, CA 94140. Received for publication 26 April 1983 and in revised form 22 June 1983. subject; similar subfractions could be obtained from each subject and were shown to have a similar ability to stimulate cholesteryl ester accumulation in mouse peritoneal macrophages. The new apo E2 variant has also been detected in a second type III hyperlipoproteinemic subject.

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