Acetoacetate protects macrophages from lactic acidosis-induced mitochondrial dysfunction by metabolic reprograming

[1]  S. Arena,et al.  CA IX Stabilizes Intracellular pH to Maintain Metabolic Reprogramming and Proliferation in Hypoxia , 2020, Frontiers in Oncology.

[2]  A. Kavazis,et al.  Mitochondrial lactate metabolism: history and implications for exercise and disease , 2020, The Journal of physiology.

[3]  M. Campone,et al.  Lactic Acidosis Together with GM-CSF and M-CSF Induces Human Macrophages toward an Inflammatory Protumor Phenotype , 2020, Cancer Immunology Research.

[4]  G. Tsujimoto,et al.  Ketone body receptor GPR43 regulates lipid metabolism under ketogenic conditions , 2019, Proceedings of the National Academy of Sciences.

[5]  Xianlin Han,et al.  Hepatocyte-Macrophage Acetoacetate Shuttle Protects against Tissue Fibrosis. , 2019, Cell metabolism.

[6]  J. Geffner,et al.  Unravelling the Interplay between Extracellular Acidosis and Immune Cells , 2018, Mediators of inflammation.

[7]  E. Ruppin,et al.  Systems analysis of intracellular pH vulnerabilities for cancer therapy , 2018, Nature Communications.

[8]  C. Libert,et al.  Reprogramming of basic metabolic pathways in microbial sepsis: therapeutic targets at last? , 2018, EMBO molecular medicine.

[9]  Ping Wang,et al.  Tissue-resident macrophages in the intestine are long lived and defined by Tim-4 and CD4 expression , 2018, The Journal of experimental medicine.

[10]  I. Dikic,et al.  Mechanism and medical implications of mammalian autophagy , 2018, Nature reviews. Molecular cell biology.

[11]  Q. Qian,et al.  Lactic Acid: No Longer an Inert and End-Product of Glycolysis. , 2017, Physiology.

[12]  O. Feron,et al.  Tumour acidosis: from the passenger to the driver's seat , 2017, Nature Reviews Cancer.

[13]  Y. C. Long,et al.  Glutamine metabolism regulates autophagy-dependent mTORC1 reactivation during amino acid starvation , 2017, Nature Communications.

[14]  Marianne O. Price,et al.  Activation of mitophagy leads to decline in Mfn2 and loss of mitochondrial mass in Fuchs endothelial corneal dystrophy , 2017, Scientific Reports.

[15]  G. Tsujimoto,et al.  The short chain fatty acid receptor GPR43 regulates inflammatory signals in adipose tissue M2-type macrophages , 2017, PloS one.

[16]  R. Shaw,et al.  AMPK: Mechanisms of Cellular Energy Sensing and Restoration of Metabolic Balance. , 2017, Molecular cell.

[17]  P. Puchalska,et al.  Multi-dimensional Roles of Ketone Bodies in Fuel Metabolism, Signaling, and Therapeutics. , 2017, Cell metabolism.

[18]  Alberto Mantovani,et al.  Tumour-associated macrophages as treatment targets in oncology , 2017, Nature Reviews Clinical Oncology.

[19]  J. Gallezot,et al.  Opposing Effects of Fasting Metabolism on Tissue Tolerance in Bacterial and Viral Inflammation , 2016, Cell.

[20]  D. Bernstein,et al.  Mitochondrial remodeling: Rearranging, recycling, and reprogramming. , 2016, Cell calcium.

[21]  K. Macleod,et al.  In Brief: Mitophagy: mechanisms and role in human disease , 2016, The Journal of pathology.

[22]  H. P. Leite,et al.  Metabolic resuscitation in sepsis: a necessary step beyond the hemodynamic? , 2016, Journal of thoracic disease.

[23]  F. Sbrana,et al.  Tumor acidosis enhances cytotoxic effects and autophagy inhibition by salinomycin on cancer cell lines and cancer stem cells , 2016, Oncotarget.

[24]  W. Zhou,et al.  Flow Cytometry-Based Assessment of Mitophagy Using MitoTracker , 2016, Front. Cell. Neurosci..

[25]  K. Clarke,et al.  The Population Pharmacokinetics of d-β-hydroxybutyrate Following Administration of (R)-3-Hydroxybutyl (R)-3-Hydroxybutyrate , 2016, The AAPS Journal.

[26]  V. Zinchenko,et al.  Intracellular pH Modulates Autophagy and Mitophagy* , 2016, The Journal of Biological Chemistry.

[27]  S. Manalis,et al.  Biophysical changes reduce energetic demand in growth factor–deprived lymphocytes , 2016, The Journal of cell biology.

[28]  C. Supuran,et al.  Metabolism and microenvironment in cancer plasticity , 2016, Cancer & Metabolism.

[29]  Gregory Lefebvre,et al.  Medium‐chain fatty acids inhibit mitochondrial metabolism in astrocytes promoting astrocyte‐neuron lactate and ketone body shuttle systems , 2016, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[30]  R. Medzhitov,et al.  Tissue biology perspective on macrophages , 2015, Nature Immunology.

[31]  S. Fernández-Arroyo,et al.  Reshaping of Human Macrophage Polarization through Modulation of Glucose Catabolic Pathways , 2015, The Journal of Immunology.

[32]  Nektarios Tavernarakis,et al.  Balancing mitochondrial biogenesis and mitophagy to maintain energy metabolism homeostasis , 2015, Cell Death and Differentiation.

[33]  J. Debnath,et al.  Autophagy at the crossroads of catabolism and anabolism , 2015, Nature Reviews Molecular Cell Biology.

[34]  Lorenzo Galluzzi,et al.  Acetyl coenzyme A: a central metabolite and second messenger. , 2015, Cell metabolism.

[35]  M. Rehli,et al.  Lactic acid delays the inflammatory response of human monocytes. , 2015, Biochemical and biophysical research communications.

[36]  Jonathan L. Sessler,et al.  Mitochondria-Immobilized pH-Sensitive Off–On Fluorescent Probe , 2014, Journal of the American Chemical Society.

[37]  G. Cline,et al.  Functional polarization of tumour-associated macrophages by tumour-derived lactic acid , 2014, Nature.

[38]  L. Hodson,et al.  The storage stability and concentration of acetoacetate differs between blood fractions. , 2014, Clinica chimica acta; international journal of clinical chemistry.

[39]  P. Codogno,et al.  Regulation of autophagy by amino acids and MTOR-dependent signal transduction , 2014, Amino Acids.

[40]  Hao Wu,et al.  Beyond Warburg effect – dual metabolic nature of cancer cells , 2014, Scientific Reports.

[41]  C. López-Otín,et al.  Regulation of autophagy by cytosolic acetyl-coenzyme A. , 2014, Molecular cell.

[42]  Tom C. Freeman,et al.  Transcriptome-Based Network Analysis Reveals a Spectrum Model of Human Macrophage Activation , 2014, Immunity.

[43]  M. Singer.  The role of mitochondrial dysfunction in sepsis-induced multi-organ failure , 2013, Virulence.

[44]  J. James,et al.  Loss of iron triggers PINK1/Parkin-independent mitophagy , 2013, EMBO reports.

[45]  J. Harper,et al.  Uba1 functions in Atg7- and Atg3-independent autophagy , 2013, Nature Cell Biology.

[46]  J. Takala,et al.  Mitochondrial function in sepsis , 2013, European journal of clinical investigation.

[47]  C. Bauvy,et al.  Glutamate dehydrogenase contributes to leucine sensing in the regulation of autophagy , 2013, Autophagy.

[48]  F. Sotgia,et al.  Ketone bodies and two-compartment tumor metabolism: Stromal ketone production fuels mitochondrial biogenesis in epithelial cancer cells , 2012, Cell cycle.

[49]  P. Codogno,et al.  Autophagy Is a Protective Mechanism for Human Melanoma Cells under Acidic Stress* , 2012, The Journal of Biological Chemistry.

[50]  M. Morgan,et al.  Induction of autophagy is essential for monocyte-macrophage differentiation. , 2012, Blood.

[51]  Alberto Mantovani,et al.  Macrophage plasticity and polarization: in vivo veritas. , 2012, The Journal of clinical investigation.

[52]  O. Shirihai,et al.  The interplay between mitochondrial dynamics and mitophagy. , 2011, Antioxidants & redox signaling.

[53]  Daniel Merl,et al.  Lactic Acidosis Triggers Starvation Response with Paradoxical Induction of TXNIP through MondoA , 2010, PLoS genetics.

[54]  Emil Alexov,et al.  On the pH‐optimum of activity and stability of proteins , 2010, Proteins.

[55]  N. Mizushima,et al.  Methods in Mammalian Autophagy Research , 2010, Cell.

[56]  P. Oefner,et al.  Lactic Acid and Acidification Inhibit TNF Secretion and Glycolysis of Human Monocytes , 2009, The Journal of Immunology.

[57]  L. Cantley,et al.  Understanding the Warburg Effect: The Metabolic Requirements of Cell Proliferation , 2009, Science.

[58]  H. Yde,et al.  Diurnal variations in the concentrations of blood acetoacetate and 3-hydroxybutyrate. The ketone body peak around midnight and its relationship to free fatty acids, glycerol, insulin, growth hormone and glucose in serum and plasma. , 2009, Acta medica Scandinavica.

[59]  A. Iwasaki,et al.  Absence of autophagy results in reactive oxygen species-dependent amplification of RLR signaling , 2009, Proceedings of the National Academy of Sciences.

[60]  M. West,et al.  The Genomic Analysis of Lactic Acidosis and Acidosis Response in Human Cancers , 2008, PLoS genetics.

[61]  T. Herbert,et al.  Inhibition of SNAT2 by metabolic acidosis enhances proteolysis in skeletal muscle. , 2008, Journal of the American Society of Nephrology.

[62]  D. Klionsky,et al.  Dissecting autophagosome formation: The missing pieces , 2008, Autophagy.

[63]  Pernille R. Jensen,et al.  Magnetic resonance imaging of pH in vivo using hyperpolarized 13C-labelled bicarbonate , 2008, Nature.

[64]  T. Herbert,et al.  Acidosis-sensing glutamine pump SNAT2 determines amino acid levels and mammalian target of rapamycin signalling to protein synthesis in L6 muscle cells. , 2007, Journal of the American Society of Nephrology : JASN.

[65]  A. Mackensen,et al.  Tumor-derived lactic acid modulates dendritic cell activation and antigen expression. , 2006, Blood.

[66]  L. Zitvogel,et al.  In vivo veritas , 2005, Nature Biotechnology.

[67]  M. Singer,et al.  Mitochondrial dysfunction in sepsis , 2003, Current infectious disease reports.

[68]  J. Bocchini,et al.  Elevated blood interleukin-6 levels in hyperketonemic type 1 diabetic patients and secretion by acetoacetate-treated cultured U937 monocytes. , 2003, Diabetes care.

[69]  J. Bocchini,et al.  Hyperketonemia increases tumor necrosis factor-alpha secretion in cultured U937 monocytes and Type 1 diabetic patients and is apparently mediated by oxidative stress and cAMP deficiency. , 2002, Diabetes.

[70]  P. Briand,et al.  Intracellular pH regulation in a nonmalignant and a derived malignant human breast cell line , 2000, Journal of cellular physiology.

[71]  H. Simmen,et al.  Analysis of pH and pO2 in abscesses, peritoneal fluid, and drainage fluid in the presence or absence of bacterial infection during and after abdominal surgery. , 1993, American journal of surgery.

[72]  I. Tannock,et al.  Reduction of intracellular pH as a possible mechanism for killing cells in acidic regions of solid tumors: effects of carbonylcyanide-3-chlorophenylhydrazone. , 1989, Cancer research.

[73]  I. Tannock,et al.  Influence of hypoxia and an acidic environment on the metabolism and viability of cultured cells: potential implications for cell death in tumors. , 1986, Cancer research.

[74]  R. Dubos.  The micro-environment of inflammation or Metchnikoff revisited. , 1955, Lancet.

[75]  Y. Yoon,et al.  Morphological control of mitochondrial bioenergetics. , 2015, Frontiers in bioscience.

[76]  Sergio Grinstein,et al.  Sensors and regulators of intracellular pH , 2010, Nature Reviews Molecular Cell Biology.

[77]  S. Messina.  Missing pieces. , 1999, Nutrition (Burbank, Los Angeles County, Calif.).

[78]  K. Ozawa,et al.  Ketogenesis during sepsis in relation to hepatic energy metabolism , 1984, Research in experimental medicine. Zeitschrift fur die gesamte experimentelle Medizin einschliesslich experimenteller Chirurgie.