Carotenoid extraction methods: A review of recent developments.

The versatile use of carotenoids in feed, food, cosmetic and pharmaceutical industries has emphasized the optimization of extraction methods to obtain the highest recovery. The choice of method for carotenoid extraction from food matrices is crucial, owing to the presence of diverse carotenoids with varied levels of polarity, and the presence of various physical and chemical barriers in the food matrices. This review highlights the theoretical aspects and recent developments of various conventional and nonconventional methods used for the extraction of carotenoids, including ultrasound-assisted extraction (UAE), pressurized liquid extraction (PLE), and supercritical fluid extraction (SFE). Recent applications of non-toxic and environmentally safe solvents (green solvents) and ionic liquids (IL) for carotenoid extraction are also described. Additionally, future research challenges in the context of carotenoids extractions are also identified.

[1]  W. Bi,et al.  Task-specific ionic liquid-assisted extraction and separation of astaxanthin from shrimp waste. , 2010, Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.

[2]  K. Christensen,et al.  Influence of green solvent extraction on carotenoid yield from shrimp (Pandalus borealis) processing waste , 2015 .

[3]  P. Andrade,et al.  Alternative and Efficient Extraction Methods for Marine-Derived Compounds , 2015, Marine drugs.

[4]  P. Zoumpoulakis,et al.  Response surface methodology toward the optimization of high-energy carotenoid extraction from Aristeus antennatus shrimp. , 2015, Analytica chimica acta.

[5]  M. Rols,et al.  A Comparative Study on the Effects of Millisecond- and Microsecond-Pulsed Electric Field Treatments on the Permeabilization and Extraction of Pigments from Chlorella vulgaris , 2015, The Journal of Membrane Biology.

[6]  E. Ibáñez,et al.  Comparison of extraction methods for selected carotenoids from macroalgae and the assessment of their seasonal/spatial variation , 2016 .

[7]  I. Strati,et al.  Enzyme and high pressure assisted extraction of carotenoids from tomato waste , 2015 .

[8]  Alejandro Cifuentes,et al.  On-line coupling of supercritical fluid extraction and chromatographic techniques. , 2017, Journal of separation science.

[9]  A. Goula,et al.  Green ultrasound-assisted extraction of carotenoids from pomegranate wastes using vegetable oils. , 2017, Ultrasonics sonochemistry.

[10]  Gongke Li,et al.  Review of online coupling of sample preparation techniques with liquid chromatography. , 2014, Analytica chimica acta.

[11]  Shen Jiachuan Supercritical Carbon Dioxide Extraction , 2010 .

[12]  Y. Keum,et al.  Progress in Microbial Carotenoids Production , 2017, Indian Journal of Microbiology.

[13]  Christian Capello,et al.  What is a green solvent? A comprehensive framework for the environmental assessment of solvents , 2007 .

[14]  F. Granado,et al.  A fast, reliable and low-cost saponification protocol for analysis of carotenoids in vegetables. , 2001 .

[15]  Jean-Paul Cadoret,et al.  Study on the microalgal pigments extraction process: Performance of microwave assisted extraction , 2011 .

[16]  Donghong Liu,et al.  Effects of supercritical CO2 fluid parameters on chemical composition and yield of carotenoids extracted from pumpkin , 2010 .

[17]  N. Moran,et al.  Lateral Transfer of Genes from Fungi Underlies Carotenoid Production in Aphids , 2010, Science.

[18]  C. A. V. Burkert,et al.  Extraction of carotenoids from Phaffia rhodozyma: A comparison between different techniques of cell disruption , 2012, Food Science and Biotechnology.

[19]  Sakamon Devahastin,et al.  Enhancement of microwave-assisted extraction via intermittent radiation: Extraction of carotenoids from carrot peels , 2014 .

[20]  I. Strati,et al.  Process optimisation for recovery of carotenoids from tomato waste. , 2011, Food chemistry.

[21]  M. Ferruzzi,et al.  Microwave-assisted extraction of lycopene in tomato peels: Effect of extraction conditions on all-trans and cis-isomer yields , 2015 .

[22]  Gokare A. Ravishankar,et al.  Pigment identification, antioxidant activity, and nutrient composition of Tinospora cordifolia (willd.) Miers ex Hook. f & Thoms fruit , 2011, International journal of food sciences and nutrition.

[23]  Y. Oh,et al.  Breaking dormancy: an energy-efficient means of recovering astaxanthin from microalgae , 2015 .

[24]  D. Murzin,et al.  Comparative study of the extraction methods for recovery of carotenoids from algae: extraction kinetics and effect of different extraction parameters , 2014 .

[25]  C. Barrow,et al.  Optimization of zeaxanthin and β-carotene extraction from Chlorella saccharophila isolated from New Zealand marine waters , 2015 .

[26]  E. Uquiche,et al.  Enhancement of pigment extraction from B. braunii pretreated using CO2 rapid depressurization , 2016, Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology].

[27]  C. Xue,et al.  Optimization of subcritical fluid extraction of carotenoids and chlorophyll a from Laminaria japonica Aresch by response surface methodology. , 2014, Journal of the science of food and agriculture.

[28]  S. Abbasi,et al.  Microemulsion-based lycopene extraction: Effect of surfactants, co-surfactants and pretreatments. , 2016, Food chemistry.

[29]  F. Blanchard,et al.  Response surface methodology applied to Supercritical Fluid Extraction (SFE) of carotenoids from Persimmon (Diospyros kaki L.). , 2016, Food chemistry.

[30]  S. Murphy,et al.  Momordica cochinchinensis Spreng. (gac) fruit carotenoids reevaluated , 2006 .

[31]  C Mantell,et al.  Comparison of supercritical fluid and ultrasound-assisted extraction of carotenoids and chlorophyll a from Dunaliella salina. , 2009, Talanta.

[32]  Kai Fan,et al.  Ultrasonic‐Assisted Solvent Extraction of Carotenoids From Rapeseed Meal: Optimization Using Response Surface Methodology , 2015 .

[33]  J. V. Oliveira,et al.  Technological process for cell disruption, extraction and encapsulation of astaxanthin from Haematococcus pluvialis. , 2016, Journal of biotechnology.

[34]  G. Mita,et al.  Supercritical Carbon Dioxide Extraction of Carotenoids from Pumpkin (Cucurbita spp.): A Review , 2014, International journal of molecular sciences.

[35]  Régis Vanderesse,et al.  Accelerated solvent extraction of carotenoids from: Tunisian Kaki (Diospyros kaki L.), peach (Prunus persica L.) and apricot (Prunus armeniaca L.). , 2015, Food chemistry.

[36]  Alejandro Cifuentes,et al.  Pressurized liquids as an alternative process to antioxidant carotenoids' extraction from Haematococcus pluvialis microalgae , 2010 .

[37]  C. Barrow,et al.  Understanding response surface optimisation to the modeling of Astaxanthin extraction from a novel strain Thraustochytrium sp. S7 , 2015 .

[38]  Jay J. Cheng,et al.  Astaxanthin-Producing Green Microalga Haematococcus pluvialis: From Single Cell to High Value Commercial Products , 2016, Front. Plant Sci..

[39]  Farid Chemat,et al.  Degradation during application of ultrasound in food processing: A review , 2013 .

[40]  Hao Wu,et al.  Effect of modifier on the composition and antioxidant activity of carotenoid extracts from pumpkin (Cucurbita maxima) by supercritical CO2 , 2013 .

[41]  Mitsuru Watanabe,et al.  Carotenoid pigment composition, polyphenol content, and antioxidant activities of extracts from orange-colored Chinese cabbage , 2011 .

[42]  Jingxin Xia,et al.  Supercritical carbon dioxide extraction of β-carotene and α-tocopherol from pumpkin: a Box–Behnken design for extraction variables , 2017 .

[43]  H. B. Sowbhagya,et al.  Enzyme-Assisted Extraction of Flavorings and Colorants from Plant Materials , 2010, Critical reviews in food science and nutrition.

[44]  Bijesh Puthusseri,et al.  Carotenoid content, its stability during drying and the antioxidant activity of commercial coriander (Coriandrum sativum L.) varieties , 2012 .

[45]  Jo‐Shu Chang,et al.  Disruption of thermo-tolerant Desmodesmus sp. F51 in high pressure homogenization as a prelude to carotenoids extraction , 2016 .

[46]  L. Gouveia,et al.  Colouring ornamental fish (Cyprinus carpio and Carassius auratus) with microalgal biomass , 2003 .

[47]  S. W. Park,et al.  Carotenoids from fruits and vegetables: Chemistry, analysis, occurrence, bioavailability and biological activities. , 2015, Food research international.

[48]  Peter J. Dunn,et al.  Green chemistry tools to influence a medicinal chemistry and research chemistry based organisation , 2008 .

[49]  N. Meeso,et al.  Lycopene and beta carotene concentration in aril oil of gac (Momordica cochinchinensis Spreng) as influenced by aril-drying process and solvents extraction , 2013 .

[50]  Eugène Vorobiev,et al.  Pulse Duration and Efficiency of Soft Cellular Tissue Disintegration by Pulsed Electric Fields , 2008 .

[51]  B. Simonovska,et al.  Influence of Synthetic Antioxidants on Extraction of All-trans-Lutein from Spinach under Air and Nitrogen Atmosphere , 2013 .

[52]  P. Roach,et al.  Optimisation of extraction conditions for recovering carotenoids and antioxidant capacity from Gac peel using response surface methodology , 2017 .

[53]  Wen-Bin Wu,et al.  Determination of carotenoids and their esters in fruits of Lycium barbarum Linnaeus by HPLC-DAD-APCI-MS. , 2008, Journal of pharmaceutical and biomedical analysis.

[54]  Gokare A. Ravishankar,et al.  Berberine and lycopene profilingduring the ontogeny of Tinosporacordifolia (Willd.) Miers ex Hook.F. & Thoms fruit , 2011 .

[55]  L. Marczak,et al.  Carotenoid and lipid extraction from Heterochlorella luteoviridis using moderate electric field and ethanol , 2016 .

[56]  M. Maraschin,et al.  Pink shrimp (P. brasiliensis and P. paulensis) residue: Supercritical fluid extraction of carotenoid fraction , 2013 .

[57]  M. Maraschin,et al.  Pink shrimp (P. brasiliensis and P. paulensis) residue: influence of extraction method on carotenoid concentration. , 2011, Talanta.

[58]  A. Cepeda,et al.  Review of methods for analysis of carotenoids , 2014 .

[59]  A. Mercadante,et al.  Composition by LC-MS/MS of New Carotenoid Esters in Mango and Citrus. , 2016, Journal of agricultural and food chemistry.

[60]  M. Riekkola,et al.  Determination of lycopene in food by on-line SFE coupled to HPLC using a single monolithic column for trapping and separation. , 2004, Journal of chromatography. A.

[61]  Y. Keum,et al.  Fatty acid and carotenoid composition of bitter melon (Momordica charantia L.) seed arils: a potentially valuable source of lycopene , 2017, Journal of Food Measurement and Characterization.

[62]  A. Kundu,et al.  Optimal extraction and fingerprinting of carotenoids by accelerated solvent extraction and liquid chromatography with tandem mass spectrometry. , 2015, Food chemistry.

[63]  Gokare A. Ravishankar,et al.  Berberine and lycopene profiling during the ontogeny of Tinospora cordifolia ( Willd . ) , 2011 .

[64]  G. S. Vijaya Raghavan,et al.  Structural modification by different pretreatment methods to enhance microwave-assisted extraction of β-carotene from carrots , 2013 .

[65]  J. M. Fernández-Sevilla,et al.  Supercritical fluid extraction of carotenoids from Scenedesmus almeriensis , 2010 .

[66]  M. Sarrafzadeh,et al.  Experimental optimization of SC-CO2 extraction of carotenoids from Dunaliella salina , 2017 .

[67]  C. Zetzl,et al.  Supercritical CO2 extraction and antioxidant activity of lycopene and β-carotene-enriched oleoresin from tomato (Lycopersicum esculentum L.) peels by-product of a Tunisian industry , 2017 .

[68]  Y. Oh,et al.  Cell-wall disruption and lipid/astaxanthin extraction from microalgae: Chlorella and Haematococcus. , 2016, Bioresource technology.

[69]  Mahesha M. Poojary,et al.  Optimization of extraction of high purity all-trans-lycopene from tomato pulp waste. , 2015, Food chemistry.

[70]  Jo‐Shu Chang,et al.  Characterization, extraction and purification of lutein produced by an indigenous microalga Scenedesmus obliquus CNW-N , 2013 .

[71]  R. Saini,et al.  Carotenoid content in vegetative and reproductive parts of commercially grown Moringa oleifera Lam. cultivars from India by LC–APCI–MS , 2014, European Food Research and Technology.

[72]  M. Meireles,et al.  Pressurized liquid extraction and low-pressure solvent extraction of carotenoids from pressed palm fiber: Experimental and economical evaluation , 2015 .

[73]  D. Rodrigues,et al.  Carotenoid esters in foods - A review and practical directions on analysis and occurrence. , 2017, Food research international.

[74]  F. G. Acién,et al.  Recovery of lutein from microalgae biomass: development of a process for Scenedesmus almeriensis biomass. , 2008, Journal of agricultural and food chemistry.

[75]  Motonobu Goto,et al.  Extraction of carotenoids and lipids from algae by supercritical CO2 and subcritical dimethyl ether , 2015 .

[76]  Farid Chemat,et al.  Is it possible to substitute hexane with green solvents for extraction of carotenoids? A theoretical versus experimental solubility study , 2016 .

[77]  E. Larsen,et al.  Simple saponification method for the quantitative determination of carotenoids in green vegetables. , 2005, Journal of agricultural and food chemistry.

[78]  L. Marczak,et al.  Ultrasound as an alternative technology to extract carotenoids and lipids from Heterochlorella luteoviridis. , 2017, Bioresource technology.

[79]  N. Shetty,et al.  Effect of dehydration methods on retention of carotenoids, tocopherols, ascorbic acid and antioxidant activity in Moringa oleifera leaves and preparation of a RTE product , 2014, Journal of Food Science and Technology.

[80]  M. Goto,et al.  Extraction of Astaxanthin from Haematococcus p luvialis Using Supercritical CO 2 and Ethanol as Entrainer , 2006 .

[81]  S. Boussiba Carotenogenesis in the green alga Haematococcus pluvialis: Cellular physiology and stress response , 2000 .

[82]  Abdul Latif Ahmad,et al.  Green extraction methods and environmental applications of carotenoids-a review , 2015 .

[83]  E. Ibáñez,et al.  Optimization of clean extraction methods to isolate carotenoids from the microalga Neochloris oleoabundans and subsequent chemical characterization using liquid chromatography tandem mass spectrometry , 2013, Analytical and Bioanalytical Chemistry.

[84]  Gokare A. Ravishankar,et al.  Astaxanthin: Sources, Extraction, Stability, Biological Activities and Its Commercial Applications—A Review , 2014, Marine drugs.

[85]  René H. Wijffels,et al.  Novel astaxanthin extraction from Haematococcus pluvialis using cell permeabilising ionic liquids , 2016 .