Lipidomic Analysis of α-Synuclein Neurotoxicity Identifies Stearoyl CoA Desaturase as a Target for Parkinson Treatment.

[1]  C. McMaster.  From yeast to humans – roles of the Kennedy pathway for phosphatidylcholine synthesis , 2018, FEBS letters.

[2]  Hongyuan Yang,et al.  Lipid droplet growth and adipocyte development: mechanistically distinct processes connected by phospholipids. , 2017, Biochimica et biophysica acta. Molecular and cell biology of lipids.

[3]  Lisa J. Lapidus,et al.  Nortriptyline inhibits aggregation and neurotoxicity of alpha-synuclein by enhancing reconfiguration of the monomeric form , 2017, Neurobiology of Disease.

[4]  J. Goodman,et al.  The collaborative work of droplet assembly. , 2017, Biochimica et biophysica acta. Molecular and cell biology of lipids.

[5]  D. Selkoe,et al.  Loss of native &agr;-synuclein multimerization by strategically mutating its amphipathic helix causes abnormal vesicle interactions in neuronal cells , 2017, Human molecular genetics.

[6]  M. Nalls,et al.  A meta-analysis of genome-wide association studies identifies 17 new Parkinson's disease risk loci , 2017, Nature Genetics.

[7]  K. Reue,et al.  Lipin proteins and glycerolipid metabolism: Roles at the ER membrane and beyond. , 2017, Biochimica et biophysica acta. Biomembranes.

[8]  Robert V Farese,et al.  Lipid Droplet Biogenesis. , 2017, Annual review of cell and developmental biology.

[9]  T. Gasser,et al.  Integrated molecular landscape of Parkinson’s disease , 2017, npj Parkinson's Disease.

[10]  Hana El-Samad,et al.  Robust Synthetic Circuits for Two-Dimensional Control of Gene Expression in Yeast. , 2017, ACS synthetic biology.

[11]  C. Galvagnion.  The Role of Lipids Interacting with α-Synuclein in the Pathogenesis of Parkinson's Disease. , 2017, Journal of Parkinson's disease.

[12]  R. Coleman,et al.  SEIPIN Regulates Lipid Droplet Expansion and Adipocyte Development by Modulating the Activity of Glycerol-3-phosphate Acyltransferase , 2016, Cell reports.

[13]  Radhey S. Gupta,et al.  Diacylglycerol Kinase-ε: Properties and Biological Roles , 2016, Front. Cell Dev. Biol..

[14]  Christer S. Ejsing,et al.  Seipin is required for converting nascent to mature lipid droplets , 2016, eLife.

[15]  Gerhard Hummer,et al.  A Eukaryotic Sensor for Membrane Lipid Saturation. , 2016, Molecular cell.

[16]  S. Gujja,et al.  Cholesterol-Independent SREBP-1 Maturation Is Linked to ARF1 Inactivation. , 2016, Cell reports.

[17]  R. Young,et al.  Parkinson-associated risk variant in enhancer element produces subtle effect on target gene expression , 2016, Nature.

[18]  Yonatan Stelzer,et al.  Parkinson-associated risk variant in enhancer element produces subtle effect on target gene expression , 2016, Nature.

[19]  Pedro Carvalho,et al.  The seipin complex Fld1/Ldb16 stabilizes ER–lipid droplet contact sites , 2015, The Journal of cell biology.

[20]  D. Selkoe,et al.  KTKEGV repeat motifs are key mediators of normal α-synuclein tetramerization: Their mutation causes excess monomers and neurotoxicity , 2015, Proceedings of the National Academy of Sciences.

[21]  R. Jaenisch,et al.  Parkinson-causing α-synuclein missense mutations shift native tetramers to monomers as a mechanism for disease initiation , 2015, Nature Communications.

[22]  Q. Gao,et al.  Seipin performs dissectible functions in promoting lipid droplet biogenesis and regulating droplet morphology , 2015, Molecular biology of the cell.

[23]  D. Eliezer,et al.  Alpha-Synuclein Function and Dysfunction on Cellular Membranes , 2014, Experimental neurobiology.

[24]  P. McLean,et al.  α-Synuclein Multimers Cluster Synaptic Vesicles and Attenuate Recycling , 2014, Current Biology.

[25]  T. Südhof,et al.  α-Synuclein assembles into higher-order multimers upon membrane binding to promote SNARE complex formation , 2014, Proceedings of the National Academy of Sciences.

[26]  S. Henry,et al.  Regulation of Gene Expression through a Transcriptional Repressor that Senses Acyl-Chain Length in Membrane Phospholipids , 2014, Developmental cell.

[27]  Chao-Wen Wang,et al.  Control of lipid droplet size in budding yeast requires the collaboration between Fld1 and Ldb16 , 2014, Journal of Cell Science.

[28]  Jean-Charles Sanchez,et al.  Proteomic analysis of human substantia nigra identifies novel candidates involved in Parkinson's disease pathogenesis , 2014, Proteomics.

[29]  B. Giasson,et al.  Evidence of Native α-Synuclein Conformers in the Human Brain* , 2014, The Journal of Biological Chemistry.

[30]  J. Loeffler,et al.  A plural role for lipids in motor neuron diseases: energy, signaling and structure , 2013, Front. Cell. Neurosci..

[31]  S. Fulton,et al.  Glucose Regulates Hypothalamic Long-chain Fatty Acid Metabolism via AMP-activated Kinase (AMPK) in Neurons and Astrocytes* , 2013, The Journal of Biological Chemistry.

[32]  Daniel F Tardiff,et al.  Yeast Reveal a “Druggable” Rsp5/Nedd4 Network that Ameliorates α-Synuclein Toxicity in Neurons , 2013, Science.

[33]  T. Südhof,et al.  Rapid Single-Step Induction of Functional Neurons from Human Pluripotent Stem Cells , 2013, Neuron.

[34]  Wei Song,et al.  GAK rs1564282 and DGKQ rs11248060 increase the risk for Parkinson’s disease in a Chinese population , 2013, Journal of Clinical Neuroscience.

[35]  Ronald Melki,et al.  G51D α‐synuclein mutation causes a novel Parkinsonian–pyramidal syndrome , 2013, Annals of neurology.

[36]  Thomas Gurry,et al.  The dynamic structure of α-synuclein multimers. , 2013, Journal of the American Chemical Society.

[37]  H. Shill,et al.  Changes in properties of serine 129 phosphorylated α-synuclein with progression of Lewy-type histopathology in human brains , 2013, Experimental Neurology.

[38]  D. Selkoe,et al.  In Vivo Cross-linking Reveals Principally Oligomeric Forms of α-Synuclein and β-Synuclein in Neurons and Non-neural Cells* , 2013, The Journal of Biological Chemistry.

[39]  S. Chandra,et al.  Monomeric Synucleins Generate Membrane Curvature* , 2012, The Journal of Biological Chemistry.

[40]  Daniel A. Lorenz,et al.  Rho Signaling Participates in Membrane Fluidity Homeostasis , 2012, PloS one.

[41]  D. Dickson.  Parkinson's disease and parkinsonism: neuropathology. , 2012, Cold Spring Harbor perspectives in medicine.

[42]  H. Groenewegen,et al.  The Proteome of the Locus Ceruleus in Parkinson's Disease: Relevance to Pathogenesis , 2012, Brain pathology.

[43]  J. Brouwers,et al.  The yeast acyltransferase Sct1p regulates fatty acid desaturation by competing with the desaturase Ole1p , 2012, Molecular biology of the cell.

[44]  Pingsheng Liu,et al.  Molecular characterization of seipin and its mutants: implications for seipin in triacylglycerol synthesis[S] , 2011, Journal of Lipid Research.

[45]  Wei Wang,et al.  A soluble α-synuclein construct forms a dynamic tetramer , 2011, Proceedings of the National Academy of Sciences.

[46]  Patrick A. Lewis,et al.  Parkinson's disease induced pluripotent stem cells with triplication of the α-synuclein locus , 2011, Nature communications.

[47]  D. Selkoe,et al.  α-Synuclein occurs physiologically as a helically folded tetramer that resists aggregation , 2011, Nature.

[48]  P. Watkins,et al.  Human Fatty Acid Transport Protein 2a/Very Long Chain Acyl-CoA Synthetase 1 (FATP2a/Acsvl1) Has a Preference in Mediating the Channeling of Exogenous n-3 Fatty Acids into Phosphatidylinositol* , 2011, The Journal of Biological Chemistry.

[49]  B. Antonny,et al.  α-Synuclein and ALPS motifs are membrane curvature sensors whose contrasting chemistry mediates selective vesicle binding , 2011, The Journal of cell biology.

[50]  Susan Lindquist,et al.  Generation of Isogenic Pluripotent Stem Cells Differing Exclusively at Two Early Onset Parkinson Point Mutations , 2011, Cell.

[51]  Thomas Vierbuchen,et al.  Induction of human neuronal cells by defined transcription factors , 2011, Nature.

[52]  K. Caldwell,et al.  Modeling dopamine neuron degeneration in Caenorhabditis elegans. , 2011, Methods in molecular biology.

[53]  P. Foley.  Lipids in Alzheimer's disease: A century-old story. , 2010, Biochimica et biophysica acta.

[54]  Thomas Vierbuchen,et al.  Direct conversion of fibroblasts to functional neurons by defined factors , 2010, Nature.

[55]  Jens Nielsen,et al.  Systems biology of lipid metabolism: From yeast to human , 2009, FEBS letters.

[56]  Carmen Birchmeier,et al.  Synaptic PRG-1 Modulates Excitatory Transmission via Lipid Phosphate-Mediated Signaling , 2009, Cell.

[57]  Ad Bax,et al.  Multiple tight phospholipid-binding modes of alpha-synuclein revealed by solution NMR spectroscopy. , 2009, Journal of molecular biology.

[58]  K. Natter,et al.  Good Fat, Essential Cellular Requirements for Triacylglycerol Synthesis to Maintain Membrane Homeostasis in Yeast* , 2009, The Journal of Biological Chemistry.

[59]  K. Obata,et al.  Preferential labeling of inhibitory and excitatory cortical neurons by endogenous tropism of adeno-associated virus and lentivirus vectors , 2009, Neuroscience.

[60]  M. Neumann,et al.  Nuclear and neuritic distribution of serine-129 phosphorylated α-synuclein in transgenic mice , 2009, Neuroscience.

[61]  Y. Chrétien,et al.  Seipin deficiency alters fatty acid Delta9 desaturation and lipid droplet formation in Berardinelli-Seip congenital lipodystrophy. , 2009, Biochimie.

[62]  Chad A. Cowan,et al.  A high-efficiency system for the generation and study of human induced pluripotent stem cells. , 2008, Cell stem cell.

[63]  T. Iwatsubo,et al.  Relationship of phosphorylated α-synuclein and tau accumulation to Aβ deposition in the cerebral cortex of dementia with Lewy bodies , 2008, Experimental Neurology.

[64]  Bernd J. Pichler,et al.  Neurodegeneration and Motor Dysfunction in a Conditional Model of Parkinson's Disease , 2008, The Journal of Neuroscience.

[65]  E. Wanker,et al.  Alpha-synuclein selectively binds to anionic phospholipids embedded in liquid-disordered domains. , 2008, Journal of molecular biology.

[66]  J. Trojanowski,et al.  Alpha-synuclein-induced aggregation of cytoplasmic vesicles in Saccharomyces cerevisiae. , 2007, Molecular biology of the cell.

[67]  Richard G. W. Anderson,et al.  The lipodystrophy protein seipin is found at endoplasmic reticulum lipid droplet junctions and is important for droplet morphology , 2007, Proceedings of the National Academy of Sciences.

[68]  R. M. Adibhatla,et al.  Role of Lipids in Brain Injury and Diseases. , 2007, Future lipidology.

[69]  T. Iwatsubo,et al.  Accumulation of phosphorylated α‐synuclein in dopaminergic neurons of transgenic mice that express human α‐synuclein , 2007 .

[70]  Peter T Lansbury,et al.  Relationships between the sequence of alpha-synuclein and its membrane affinity, fibrillization propensity, and yeast toxicity. , 2007, Journal of molecular biology.

[71]  P. Black,et al.  Yeast acyl-CoA synthetases at the crossroads of fatty acid metabolism and regulation. , 2007, Biochimica et biophysica acta.

[72]  P. Lansbury,et al.  Interactions among α-synuclein, dopamine, and biomembranes , 2007, Journal of Molecular Neuroscience.

[73]  R. Barbour,et al.  Phosphorylation of Ser-129 Is the Dominant Pathological Modification of α-Synuclein in Familial and Sporadic Lewy Body Disease* , 2006, Journal of Biological Chemistry.

[74]  D. Gantz,et al.  Interactions between fatty acids and α-synuclein Published, JLR Papers in Press, May 10, 2006. , 2006, Journal of Lipid Research.

[75]  K. Natter,et al.  Obese Yeast: Triglyceride Lipolysis Is Functionally Conserved from Mammals to Yeast* , 2006, Journal of Biological Chemistry.

[76]  C. Lücke,et al.  Interactions between fatty acids and alpha-synuclein. , 2006, Journal of lipid research.

[77]  Udo Rüb,et al.  Vulnerability of cortical neurons to Alzheimer's and Parkinson's diseases. , 2006, Journal of Alzheimer's disease : JAD.

[78]  Thomas C. Südhof,et al.  α-Synuclein Cooperates with CSPα in Preventing Neurodegeneration , 2005, Cell.

[79]  G. Daum,et al.  Formation and mobilization of neutral lipids in the yeast Saccharomyces cerevisiae. , 2005, Biochemical Society transactions.

[80]  W. Xia,et al.  Dimerization of Parkinson's disease-causing DJ-1 and formation of high molecular weight complexes in human brain , 2004, Molecular and Cellular Neuroscience.

[81]  Michel Goedert,et al.  Mutation E46K increases phospholipid binding and assembly into filaments of human α‐synuclein , 2004 .

[82]  J. Alexander,et al.  Omega-Oxidation of Monocarboxylic Acids in Rat Brain , 1998, Neurochemical Research.

[83]  S. Lindquist,et al.  Yeast Cells Provide Insight into Alpha-Synuclein Biology and Pathobiology , 2003, Science.

[84]  Janel O. Johnson,et al.  α-Synuclein Locus Triplication Causes Parkinson's Disease , 2003, Science.

[85]  J. Payton,et al.  Epitope mapping and specificity of the anti-α-synuclein monoclonal antibody Syn-1 in mouse brain and cultured cell lines , 2003, Neuroscience Letters.

[86]  Paul N. Black,et al.  Transmembrane Movement of Exogenous Long-Chain Fatty Acids: Proteins, Enzymes, and Vectorial Esterification , 2003, Microbiology and Molecular Biology Reviews.

[87]  R. Haller,et al.  Energy Contribution of Octanoate to Intact Rat Brain Metabolism Measured by 13C Nuclear Magnetic Resonance Spectroscopy , 2003, The Journal of Neuroscience.

[88]  Robert V Farese,et al.  Triglyceride accumulation protects against fatty acid-induced lipotoxicity , 2003, Proceedings of the National Academy of Sciences of the United States of America.

[89]  Matthew P Frosch,et al.  The Formation of Highly Soluble Oligomers of α-Synuclein Is Regulated by Fatty Acids and Enhanced in Parkinson's Disease , 2003, Neuron.

[90]  R. McKay,et al.  Generating CNS neurons from embryonic, fetal, and adult stem cells. , 2003, Methods in enzymology.

[91]  P. Black,et al.  Fatty Acid Transport in Saccharomyces cerevisiae , 2002, The Journal of Biological Chemistry.

[92]  P. S. St George-Hyslop,et al.  Defective membrane interactions of familial Parkinson's disease mutant A30P α-synuclein , 2002 .

[93]  Rebecca A. Betensky,et al.  α-Synuclein occurs in lipid-rich high molecular weight complexes, binds fatty acids, and shows homology to the fatty acid-binding proteins , 2001, Proceedings of the National Academy of Sciences of the United States of America.

[94]  A. Jonas,et al.  Stabilization of α-Synuclein Secondary Structure upon Binding to Synthetic Membranes* , 1998, The Journal of Biological Chemistry.

[95]  J. de Vellis,et al.  Capacity for substrate utilization in oxidative metabolism by neurons, astrocytes, and oligodendrocytes from developing brain in primary culture , 1987, Journal of neuroscience research.

[96]  P. Sastry,et al.  Lipids of nervous tissue: composition and metabolism. , 1985, Progress in lipid research.