Morphological and immunohistochemical characterization of alterations induced by doxorubicin and the chronological course of recovering of various tissues in rabbits

Alterations caused by doxorubicin (DOX) in rabbits and their course of recovering was characterized nd DOX dose lymphatic organs were markedly hypocellular, testes and skin were atrophic, and myocardial degeneration occurred. Two weeks after the last DOX dose hematopoetic organs appeared to be hyperplastic. After six weeks hematopoetic tissues and testes were normal, whereas the skin was still atrophic. Myocardial fibrosis, as well as renal cysts and fibrosis developed. In conclusion, using doxorubicin the different reaction patterns of the various organs should consider forensic aspects (i.e. potentia generandi) and carefull interpretation of experimental results.