Synthesis and Characterization of Polylactic Acid Tubular Scaffolds with Improved Mechanical Properties for Vascular Tissue Engineering

In this study, a new electrospinning method for producing of cycloid fibers has been developed. The cycloid polylactic acid (PLA) fibers produced by this method were then collected (with a 4 mm inner diameter) by a rotational collector as tubular scaffolds for vascular tissue engineering. The morphology, degradation behavior, porosity and mechanical properties of the produced tubular scaffolds were investigated and compared with conventional tubular scaffolds manufactured with random fibers. The results from the tensile tests demonstrated that the mechanical strength and Young module of the prepared scaffolds by cycloid fibers were significantly higher than conventional tubular random fibers. This improvement in the mechanical properties of cycloid fibers justifies the widespread use of these scaffolds in tissue engineering in order to produce more strengthened vessels.

[1]  Qizhi Chen,et al.  Elastomeric biomaterials for tissue engineering , 2013 .

[2]  M. Mozafari,et al.  Synthesis and characterization of electrospun polyvinyl alcohol nanofibrous scaffolds modified by blending with chitosan for neural tissue engineering , 2012, International journal of nanomedicine.

[3]  D. Bonn,et al.  Micro helical polymeric structures produced by variable voltage direct electrospinning , 2011, 1109.2432.

[4]  M. Radisic,et al.  Endothelial cells guided by immobilized gradients of vascular endothelial growth factor on porous collagen scaffolds. , 2011, Acta biomaterialia.

[5]  L. Ye,et al.  Electrospinning and biocompatibility evaluation of biodegradable polyurethanes based on L-lysine diisocyanate and L-lysine chain extender. , 2011, Journal of biomedical materials research. Part A.

[6]  James J. Yoo,et al.  Bilayered scaffold for engineering cellularized blood vessels. , 2010, Biomaterials.

[7]  S. Kundu,et al.  Electrospinning: a fascinating fiber fabrication technique. , 2010, Biotechnology advances.

[8]  A. Janorkar,et al.  Poly(lactic acid) modifications , 2010 .

[9]  N. L'Heureux,et al.  Mechanical properties of completely autologous human tissue engineered blood vessels compared to human saphenous vein and mammary artery. , 2009, Biomaterials.

[10]  Jie Yu,et al.  Production of aligned helical polymer nanofibers by electrospinning , 2008 .

[11]  Katja Schenke-Layland,et al.  Three-dimensional electrospun ECM-based hybrid scaffolds for cardiovascular tissue engineering. , 2008, Biomaterials.

[12]  Horst A von Recum,et al.  Electrospinning: applications in drug delivery and tissue engineering. , 2008, Biomaterials.

[13]  Matthew P. Brennan,et al.  Small-diameter biodegradable scaffolds for functional vascular tissue engineering in the mouse model. , 2008, Biomaterials.

[14]  Benjamin Chu,et al.  Functional electrospun nanofibrous scaffolds for biomedical applications. , 2007, Advanced drug delivery reviews.

[15]  Gregory C Rutledge,et al.  Formation of fibers by electrospinning. , 2007, Advanced drug delivery reviews.

[16]  Darrell H. Reneker,et al.  Buckling of jets in electrospinning , 2007 .

[17]  J. Goddard,et al.  Polymer surface modification for the attachment of bioactive compounds , 2007 .

[18]  Jöns Hilborn,et al.  Poly(lactic acid) fiber : An overview , 2007 .

[19]  A. Boccaccini,et al.  Biodegradable and bioactive porous polymer/inorganic composite scaffolds for bone tissue engineering. , 2006, Biomaterials.

[20]  Sean J Kirkpatrick,et al.  Development of a reinforced porcine elastin composite vascular scaffold. , 2006, Journal of biomedical materials research. Part A.

[21]  F P T Baaijens,et al.  Design of scaffolds for blood vessel tissue engineering using a multi-layering electrospinning technique. , 2005, Acta biomaterialia.

[22]  Antonios G Mikos,et al.  In vitro degradation of porous poly(propylene fumarate)/poly(DL-lactic-co-glycolic acid) composite scaffolds. , 2005, Biomaterials.

[23]  Julie H. Campbell,et al.  Advances in vascular tissue engineering. , 2003, Cardiovascular pathology : the official journal of the Society for Cardiovascular Pathology.

[24]  Cornelius Borst,et al.  Mechanical properties of porcine and human arteries: implications for coronary anastomotic connectors. , 2003, The Annals of thoracic surgery.

[25]  Sung Chul Yoon,et al.  Thermal and mechanical characteristics of poly(L-lactic acid) nanocomposite scaffold. , 2003, Biomaterials.

[26]  Robert E Guldberg,et al.  Microarchitectural and mechanical characterization of oriented porous polymer scaffolds. , 2003, Biomaterials.

[27]  Darrell H. Reneker,et al.  Bending instability of electrically charged liquid jets of polymer solutions in electrospinning , 2000 .

[28]  D J Mooney,et al.  Bioabsorbable polymer scaffolds for tissue engineering capable of sustained growth factor delivery. , 2000, Journal of controlled release : official journal of the Controlled Release Society.

[29]  D. Vashaee,et al.  Electrospun nanofibers: from filtration membranes to highly specialized tissue engineering scaffolds. , 2014, Journal of nanoscience and nanotechnology.

[30]  Qiguang Wang,et al.  THE EFFECT OF POROSITY ON THE STRUCTURE AND PROPERTIES OF CALCIUM POLYPHOSPHATE BIOCERAMICS , 2011 .

[31]  L. Bačáková,et al.  Blood vessel replacement: 50 years of development and tissue engineering paradigms in vascular surgery. , 2009, Physiological research.