4-Amino-2-cyanopyrimidines: novel scaffold for nonpeptidic cathepsin S inhibitors.
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T. Kanazawa | H. Hirao | K. Masuya | A. Hallett | T. Kosaka | F. Yokokawa | Yuki Iwaki | G. Iwasaki | Yuko Hitomi | O. Irie | Masashi Kishida | Kazuhide Konishi | T. Ehara | Atsushi Toyao | H. Gunji | J. Sakaki | T. Hart | A. Iwasaki | Keiko Tanabe
[1] T. Kanazawa,et al. Discovery of selective and nonpeptidic cathepsin S inhibitors. , 2008, Bioorganic & medicinal chemistry letters.
[2] B. Maryanoff,et al. Inhibitors of proteases and amide hydrolases that employ an alpha-ketoheterocycle as a key enabling functionality. , 2008, Bioorganic & medicinal chemistry.
[3] A. Ray,et al. Cysteine cathepsin S as an immunomodulatory target: present and future trends , 2008, Expert opinion on therapeutic targets.
[4] O. Ohmori,et al. Novel scaffold for cathepsin K inhibitors. , 2007, Bioorganic & medicinal chemistry letters.
[5] Wen Jiang,et al. Pyrazole-based cathepsin S inhibitors with improved cellular potency. , 2007, Bioorganic & medicinal chemistry letters.
[6] M. Percival,et al. The identification of potent, selective, and bioavailable cathepsin S inhibitors. , 2007, Bioorganic & medicinal chemistry letters.
[7] S. Bevan,et al. Role of the cysteine protease cathepsin S in neuropathic hyperalgesia , 2007, PAIN.
[8] S. Bevan,et al. Inhibition of spinal microglial cathepsin S for the reversal of neuropathic pain , 2007, Proceedings of the National Academy of Sciences.
[9] Jennifer L. Harris,et al. Synthesis and SAR of succinamide peptidomimetic inhibitors of cathepsin S. , 2007, Bioorganic & medicinal chemistry letters.
[10] M. Hao,et al. Identification of a novel class of succinyl-nitrile-based Cathepsin S inhibitors. , 2007, Bioorganic & medicinal chemistry letters.
[11] G. Spraggon,et al. Characterization and optimization of selective, nonpeptidic inhibitors of cathepsin S with an unprecedented binding mode. , 2007, Journal of medicinal chemistry.
[12] E. Altmann,et al. 2-Cyano-pyrimidines: a new chemotype for inhibitors of the cysteine protease cathepsin K. , 2007, Journal of medicinal chemistry.
[13] P. Janser,et al. A cassette-dosing approach for improvement of oral bioavailability of dual TACE/MMP inhibitors. , 2006, Bioorganic & Medicinal Chemistry Letters.
[14] K. Nakano,et al. Design of an organocatalyst for the enantioselective Diels-Alder reaction with alpha-acyloxyacroleins. , 2005, Journal of the American Chemical Society.
[15] Ronald E White,et al. Whatever happened to cassette-dosing pharmacokinetics? , 2004, Drug discovery today.
[16] Traian Sulea,et al. Specificity determinants of human cathepsin s revealed by crystal structures of complexes. , 2003, Biochemistry.
[17] E. Purisima,et al. Design of noncovalent inhibitors of human cathepsin L. From the 96-residue proregion to optimized tripeptides. , 2002, Journal of medicinal chemistry.
[18] H. Ploegh,et al. Essential role for cathepsin S in MHC class II-associated invariant chain processing and peptide loading. , 1996, Immunity.