Transcriptional regulation by STAT6

[1]  R. Lahesmaa,et al.  Genes in T Lymphocytes Identification of Novel IL-4/Stat6-Regulated , 2013 .

[2]  M. Kaplan,et al.  Regulating Il9 transcription in T helper cells. , 2011, Trends in immunology.

[3]  A. Keegan,et al.  STAT6 Expression in Multiple Cell Types Mediates the Cooperative Development of Allergic Airway Disease , 2011, The Journal of Immunology.

[4]  David E Levy,et al.  The transcription factor STAT3 is required for T helper 2 cell development. , 2011, Immunity.

[5]  W. Wood,et al.  Dynamic BRG1 Recruitment during T Helper Differentiation and Activation Reveals Distal Regulatory Elements , 2011, Molecular and Cellular Biology.

[6]  R. Evans,et al.  STAT6 Transcription Factor Is a Facilitator of the Nuclear Receptor PPARγ-Regulated Gene Expression in Macrophages and Dendritic Cells , 2010, Immunity.

[7]  S. Goenka,et al.  PARP-14 Functions as a Transcriptional Switch for Stat6-dependent Gene Activation* , 2010, The Journal of Biological Chemistry.

[8]  David Voehringer,et al.  Alternatively activated macrophages inhibit T-cell proliferation by Stat6-dependent expression of PD-L2. , 2010, Blood.

[9]  Yutaka Suzuki,et al.  STAT6-mediated displacement of polycomb by trithorax complex establishes long-term maintenance of GATA3 expression in T helper type 2 cells , 2010, The Journal of experimental medicine.

[10]  A. Altman Faculty Opinions recommendation of The transcription factor PU.1 is required for the development of IL-9-producing T cells and allergic inflammation. , 2010 .

[11]  C. Zang,et al.  Discrete roles of STAT4 and STAT6 transcription factors in tuning epigenetic modifications and transcription during T helper cell differentiation. , 2010, Immunity.

[12]  Matej Oresic,et al.  Genome-wide profiling of interleukin-4 and STAT6 transcription factor regulation of human Th2 cell programming. , 2010, Immunity.

[13]  M. Kaplan,et al.  IL-4 Regulates Skin Homeostasis and the Predisposition toward Allergic Skin Inflammation , 2010, The Journal of Immunology.

[14]  Carol E. Jones,et al.  Regulation of mucin expression in respiratory diseases. , 2009, Biochemical Society transactions.

[15]  C. Watson Immune cell regulators in mouse mammary development and involution. , 2009, Journal of animal science.

[16]  S. Gordon,et al.  Alternative activation of macrophages: an immunologic functional perspective. , 2009, Annual review of immunology.

[17]  S. Tuomela,et al.  Identification of novel Stat6 regulated proteins in IL‐4‐treated mouse lymphocytes , 2009, Proteomics.

[18]  S. Khoury,et al.  A tale of two STAT6 knock out mice in the induction of experimental autoimmune encephalomyelitis , 2009, Journal of Neuroimmunology.

[19]  V. Kuchroo,et al.  IL-4 inhibits TGF-β-induced Foxp3+ T cells and, together with TGF-β, generates IL-9+ IL-10+ Foxp3− effector T cells , 2008, Nature Immunology.

[20]  P. Openshaw Faculty Opinions recommendation of Transforming growth factor-beta 'reprograms' the differentiation of T helper 2 cells and promotes an interleukin 9-producing subset. , 2008 .

[21]  M. Pazin,et al.  BRG1-Mediated Chromatin Remodeling Regulates Differentiation and Gene Expression of T Helper Cells , 2008, Molecular and Cellular Biology.

[22]  Joanna M. Roberts,et al.  In vivo studies fail to reveal a role for IL-4 or STAT6 signaling in Th2 lymphocyte differentiation , 2008, Proceedings of the National Academy of Sciences.

[23]  R. Schleimer,et al.  Interleukin-4, interleukin-13, signal transducer and activator of transcription factor 6, and allergic asthma. , 2008, Current molecular medicine.

[24]  M. Kaplan,et al.  IL-4 Is a Critical Determinant in the Generation of Allergic Inflammation Initiated by a Constitutively Active Stat6 , 2008, The Journal of Immunology.

[25]  M. Boguniewicz,et al.  Loricrin and involucrin expression is down-regulated by Th2 cytokines through STAT-6. , 2008, Clinical immunology.

[26]  Daniel Panne,et al.  The enhanceosome. , 2008, Current opinion in structural biology.

[27]  M. Pazin,et al.  BRG 1-Mediated Chromatin Remodeling Regulates Differentiation and Gene Expression of T Helper Cells † , 2008 .

[28]  C. Watson,et al.  The IL-4/IL-13/Stat6 signalling pathway promotes luminal mammary epithelial cell development , 2007, Development.

[29]  M. Kaplan,et al.  IL‐4‐stimulated NF‐κB activity is required for Stat6 DNA binding , 2007 .

[30]  S. Cho,et al.  Collaborator of Stat6 (CoaSt6)-associated Poly(ADP-ribose) Polymerase Activity Modulates Stat6-dependent Gene Transcription* , 2007, Journal of Biological Chemistry.

[31]  M. Kaplan,et al.  IL-4-stimulated NF-kappaB activity is required for Stat6 DNA binding. , 2007, Journal of Leukocyte Biology.

[32]  O. Silvennoinen,et al.  Characterization of RNA helicase A as component of STAT6-dependent enhanceosome , 2006, Nucleic acids research.

[33]  D. Hebenstreit,et al.  Signaling mechanisms, interaction partners, and target genes of STAT6. , 2006, Cytokine & growth factor reviews.

[34]  Bogdan Tanasa,et al.  Regulation of Th2 differentiation and Il4 locus accessibility. , 2006, Annual review of immunology.

[35]  M. Boothby,et al.  Selective potentiation of Stat-dependent gene expression by collaborator of Stat6 (CoaSt6), a transcriptional cofactor. , 2006, Proceedings of the National Academy of Sciences of the United States of America.

[36]  Bjoern Peters,et al.  Chronic ethanol ingestion in rats decreases granulocyte-macrophage colony-stimulating factor receptor expression and downstream signaling in the alveolar macrophage. , 1997, The Journal of Immunology.

[37]  S. Morris,et al.  Induction of arginase I transcription by IL-4 requires a composite DNA response element for STAT6 and C/EBPbeta. , 2005, Gene.

[38]  M. Kaplan,et al.  Interleukin (IL)-4 inhibits IL-10 to promote IL-12 production by dendritic cells , 2005, The Journal of experimental medicine.

[39]  Kotaro Suzuki,et al.  Indispensable Role of Stat5a in Stat6-Independent Th2 Cell Differentiation and Allergic Airway Inflammation1 , 2005, The Journal of Immunology.

[40]  F. Finkelman,et al.  Interleukin‐4‐ and interleukin‐13‐mediated host protection against intestinal nematode parasites , 2004, Immunological reviews.

[41]  A. Schröder,et al.  The Transcriptional Co-activator p/CIP (NCoA-3) Is Up-regulated by STAT6 and Serves as a Positive Regulator of Transcriptional Activation by STAT6* , 2004, Journal of Biological Chemistry.

[42]  P. Murray,et al.  Enhancer-Mediated Control of Macrophage-Specific Arginase I Expression1 , 2004, The Journal of Immunology.

[43]  Yuling Wang,et al.  Interleukin 4 Regulates Phosphorylation of Serine 756 in the Transactivation Domain of Stat6 , 2004, Journal of Biological Chemistry.

[44]  F. Alt,et al.  Induction of Activation-induced Cytidine Deaminase Gene Expression by Il-4 and Cd40 Ligation Is Dependent on Stat6 and Nfkb , 2022 .

[45]  C. Litterst,et al.  Structure of the NCoA-1/SRC-1 PAS-B domain bound to the LXXLL motif of the STAT6 transactivation domain. , 2004, Journal of molecular biology.

[46]  M. Boothby,et al.  Differential Roles of C-terminal Activation Motifs in the Establishment of Stat6 Transcriptional Specificity* , 2003, Journal of Biological Chemistry.

[47]  M. Rothenberg,et al.  Intratracheal IL-13 induces eosinophilic esophagitis by an IL-5, eotaxin-1, and STAT6-dependent mechanism. , 2003, Gastroenterology.

[48]  W. Paul,et al.  Stat5 activation plays a critical role in Th2 differentiation. , 2003, Immunity.

[49]  R. Lahesmaa,et al.  Identification of Novel IL-4/Stat6-Regulated Genes in T Lymphocytes1 , 2003, The Journal of Immunology.

[50]  O. Silvennoinen,et al.  PU.1 is required for transcriptional activation of the Stat6 response element in the Igϵ promoter , 2003 .

[51]  M. Kaplan,et al.  Expression of a Constitutively Active Stat6 In Vivo Alters Lymphocyte Homeostasis with Distinct Effects in T and B Cells1 , 2003, The Journal of Immunology.

[52]  A. Stütz,et al.  The Th2 Cell Cytokines IL-4 and IL-13 Regulate Found in Inflammatory Zone 1/Resistin-Like Molecule α Gene Expression by a STAT6 and CCAAT/Enhancer-Binding Protein-Dependent Mechanism , 2003, The Journal of Immunology.

[53]  O. Silvennoinen,et al.  PU.1 is required for transcriptional activation of the Stat6 response element in the Igepsilon promoter. , 2003, European journal of immunology.

[54]  C. Litterst,et al.  An LXXLL Motif in the Transactivation Domain of STAT6 Mediates Recruitment of NCoA-1/SRC-1* , 2002, The Journal of Biological Chemistry.

[55]  E. Kieff,et al.  Identification of p100 as a coactivator for STAT6 that bridges STAT6 with RNA polymerase II , 2002, The EMBO journal.

[56]  D. Sheppard,et al.  Direct effects of interleukin-13 on epithelial cells cause airway hyperreactivity and mucus overproduction in asthma , 2002, Nature Medicine.

[57]  M. White,et al.  Interleukin-4-mediated Protection of Primary B Cells from Apoptosis through Stat6-dependent Up-regulation of Bcl-xL* , 2002, The Journal of Biological Chemistry.

[58]  R. Flavell,et al.  Cutting Edge: Changes in Histone Acetylation at the IL-4 and IFN-γ Loci Accompany Th1/Th2 Differentiation , 2002, The Journal of Immunology.

[59]  Anjana Rao,et al.  TH cell differentiation is accompanied by dynamic changes in histone acetylation of cytokine genes , 2002, Nature Immunology.

[60]  Booki Min,et al.  Growth factor independent-1 induced by IL-4 regulates Th2 cell proliferation. , 2002, Immunity.

[61]  A. Agresti,et al.  c-Rel is a selective activator of a novel IL-4/CD40 responsive element in the human Ig gamma4 germline promoter. , 2002, Molecular immunology.

[62]  P. Pavlidis,et al.  Cutting Edge: STAT6 Serves as a Positive and Negative Regulator of Gene Expression in IL-4-Stimulated B Lymphocytes1 , 2002, The Journal of Immunology.

[63]  C. Litterst,et al.  Transcriptional Activation by STAT6 Requires the Direct Interaction with NCoA-1* , 2001, The Journal of Biological Chemistry.

[64]  P. Shankaranarayanan,et al.  Acetylation by Histone Acetyltransferase CREB-binding Protein/p300 of STAT6 Is Required for Transcriptional Activation of the 15-Lipoxygenase-1 Gene* , 2001, The Journal of Biological Chemistry.

[65]  P. Howarth,et al.  Signal transducer and activator of transcription 6 (STAT-6) expression and function in asthmatic bronchial epithelium. , 2001, The Journal of allergy and clinical immunology.

[66]  S. Khoury,et al.  Effect of targeted disruption of STAT4 and STAT6 on the induction of experimental autoimmune encephalomyelitis. , 2001, The Journal of clinical investigation.

[67]  S. Akira,et al.  Enhanced resistance in STAT6-deficient mice to infection with ectromelia virus , 2001, Proceedings of the National Academy of Sciences of the United States of America.

[68]  A. Tager,et al.  Signal Transducer and Activator of Transcription 6 Controls Chemokine Production and T Helper Cell Type 2 Cell Trafficking in Allergic Pulmonary Inflammation , 2001, The Journal of experimental medicine.

[69]  H. Maassab,et al.  IL-13-Induced Airway Hyperreactivity During Respiratory Syncytial Virus Infection Is STAT6 Dependent1 , 2001, The Journal of Immunology.

[70]  R. Tarleton,et al.  Increased Susceptibility of Stat4-Deficient and Enhanced Resistance in Stat6-Deficient Mice to Infection with Trypanosoma cruzi1 , 2000, The Journal of Immunology.

[71]  Takashi Tanaka,et al.  The biology of Stat4 and Stat6 , 2000, Oncogene.

[72]  A. Sher,et al.  Single Cell Analysis Reveals That IL-4 Receptor/Stat6 Signaling Is Not Required for the In Vivo or In Vitro Development of CD4+ Lymphocytes with a Th2 Cytokine Profile , 2000, The Journal of Immunology.

[73]  F. Finkelman,et al.  Stat6 Regulation of In Vivo IL-4 Responses1 , 2000, The Journal of Immunology.

[74]  H. Gamble,et al.  Stat6 Signaling Promotes Protective Immunity Against Trichinella spiralis Through a Mast Cell- and T Cell-Dependent Mechanism1 , 2000, The Journal of Immunology.

[75]  H. Kiyono,et al.  Systemically derived large intestinal CD4(+) Th2 cells play a central role in STAT6-mediated allergic diarrhea. , 2000, The Journal of clinical investigation.

[76]  V. Casolaro,et al.  Activation of Eotaxin Gene Transcription by NF-κB and STAT6 in Human Airway Epithelial Cells , 1999, The Journal of Immunology.

[77]  M. Kaplan,et al.  Stat6-dependent and -independent pathways for IL-4 production. , 1999, Journal of immunology.

[78]  M. Boothby,et al.  Paired Stat6 C-terminal transcription activation domains required both for inhibition of an IFN-responsive promoter and trans-activation. , 1999, Journal of immunology.

[79]  A. Stütz,et al.  Functional synergism of STAT6 with either NF-kappa B or PU.1 to mediate IL-4-induced activation of IgE germline gene transcription. , 1999, Journal of immunology.

[80]  J. Petersen,et al.  Autoreactive CD4+ T cells protect from autoimmune diabetes via bystander suppression using the IL-4/Stat6 pathway. , 1999, Immunity.

[81]  Bernd Groner,et al.  p300/CBP is required for transcriptional induction by interleukin-4 and interacts with Stat6 , 1999, Nucleic Acids Res..

[82]  N. Reich,et al.  Cooperation of the transcriptional coactivators CBP and p300 with Stat6. , 1999, Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research.

[83]  P. Casali,et al.  The evolutionarily conserved sequence upstream of the human Ig heavy chain S gamma 3 region is an inducible promoter: synergistic activation by CD40 ligand and IL-4 via cooperative NF-kappa B and STAT-6 binding sites. , 1999, Journal of immunology.

[84]  V. Casolaro,et al.  Activation of eotaxin gene transcription by NF-kappa B and STAT6 in human airway epithelial cells. , 1999, Journal of immunology.

[85]  D. Conrad,et al.  STAT6, NF-kappaB and C/EBP in CD23 expression and IgE production. , 1998, International immunology.

[86]  U. Schindler,et al.  Synergistic Activation of the Germline ε Promoter Mediated by Stat6 and C/EBPβ , 1998, The Journal of Immunology.

[87]  J. Stavnezer,et al.  Interaction of Stat6 and NF-κB: Direct Association and Synergistic Activation of Interleukin-4-Induced Transcription , 1998, Molecular and Cellular Biology.

[88]  S. Akira,et al.  Abrogation of Bronchial Eosinophilic Inflammation and Airway Hyperreactivity in Signal Transducers and Activators of Transcription (STAT)6-deficient Mice , 1998, The Journal of experimental medicine.

[89]  M. Kaplan,et al.  Stat Proteins Control Lymphocyte Proliferation by Regulating p27Kip1 Expression , 1998, Molecular and Cellular Biology.

[90]  M. Wills-Karp,et al.  Signal Transducer and Activator of Transcription Factor 6 (Stat6)-deficient Mice Are Protected from Antigen-induced Airway Hyperresponsiveness and Mucus Production , 1998, The Journal of experimental medicine.

[91]  M. Kaplan,et al.  Th2 cells are required for the Schistosoma mansoni egg-induced granulomatous response. , 1998, Journal of immunology.

[92]  F. Finkelman,et al.  IL-13, IL-4Ralpha, and Stat6 are required for the expulsion of the gastrointestinal nematode parasite Nippostrongylus brasiliensis. , 1998, Immunity.

[93]  U. Schindler,et al.  Synergistic activation of the germline epsilon promoter mediated by Stat6 and C/EBP beta. , 1998, Journal of immunology.

[94]  A. Stütz,et al.  Cooperation of binding sites for STAT6 and NF kappa B/rel in the IL-4-induced up-regulation of the human IgE germline promoter. , 1997, Journal of immunology.

[95]  P. Rothman,et al.  Identification of a STAT6 domain required for IL-4-induced activation of transcription. , 1997, Journal of immunology.

[96]  B. Groner,et al.  Epithelial Cells. Mammary Stat5 and Stat6 in Lymphoid Cells and Comparison of the Transactivation Domains Of , 1997 .

[97]  J. Stavnezer,et al.  CD40 cross-linking induces Ig epsilon germline transcripts in B cells via activation of NF-kappaB: synergy with IL-4 induction. , 1997, Journal of immunology.

[98]  S. Akira,et al.  STAT6: its role in interleukin 4-mediated biological functions , 1997, Journal of Molecular Medicine.

[99]  D. Katz,et al.  Analysis of the promoter elements necessary for IL-4 and anti-CD40 antibody induction of murine Fc epsilon RII (CD23): comparison with the germline epsilon promoter. , 1997, Journal of immunology.

[100]  S. Akira,et al.  Impaired IL-13-mediated functions of macrophages in STAT6-deficient mice. , 1996, Journal of immunology.

[101]  U. Schindler,et al.  Requirements for interleukin-4-induced gene expression and functional characterization of Stat6 , 1996, Molecular and cellular biology.

[102]  W. Paul,et al.  Lack of IL-4-induced Th2 response and IgE class switching in mice with disrupted State6 gene , 1996, Nature.

[103]  S. Akira,et al.  Essential role of Stat6 in IL-4 signalling , 1996, Nature.

[104]  M. Kaplan,et al.  Stat6 is required for mediating responses to IL-4 and for development of Th2 cells. , 1996, Immunity.

[105]  S. McKnight,et al.  Components of a Stat recognition code: evidence for two layers of molecular selectivity. , 1995, Immunity.

[106]  W. Paul,et al.  Cloning of murine Stat6 and human Stat6, Stat proteins that are tyrosine phosphorylated in responses to IL-4 and IL-3 but are not required for mitogenesis , 1995, Molecular and cellular biology.

[107]  J. Stavnezer,et al.  Characterization of an interleukin 4 (IL-4) responsive region in the immunoglobulin heavy chain germline epsilon promoter: regulation by NF- IL-4, a C/EBP family member and NF-kappa B/p50 , 1995, The Journal of experimental medicine.

[108]  S. McKnight,et al.  An interleukin-4-induced transcription factor: IL-4 Stat. , 1994, Science.

[109]  N. Reich,et al.  Requirement of tyrosine phosphorylation for rapid activation of a DNA binding factor by IL-4. , 1993, Science.