Microfluidic resonant waveguide grating biosensor system for whole cell sensing

We report on a fluidic resonant waveguide grating (RWG) biosensorsystem that enables medium throughput measurements of cellular responses under microfluidics in a 32-well format. Dynamic mass redistribution assays under microfluidics differentiate the cross-desensitization process between the β 2 -adrenoceptor agonist epinephrine and the adenylate cyclase activator forskolin mediated signaling. This system opens new possibility to study cellular processes that are otherwise difficult to achieve using conventional RWG configurations.

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