In vivo drug discovery in the zebrafish
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[1] Clayton M. Christensen. The Innovator's Dilemma: When New Technologies Cause Great Firms to Fail , 2013 .
[2] L. Zon,et al. Effects of lethal irradiation in zebrafish and rescue by hematopoietic cell transplantation. , 2004, Blood.
[3] Nancy Hopkins,et al. Identification of 315 genes essential for early zebrafish development. , 2004, Proceedings of the National Academy of Sciences of the United States of America.
[4] Mark S. Miller,et al. A genetic screen in zebrafish identifies cilia genes as a principal cause of cystic kidney , 2004, Development.
[5] J. Fetcho,et al. Cyclic AMP-Induced Repair of Zebrafish Spinal Circuits , 2004, Science.
[6] C. Tyler,et al. Impacts of 17β-estradiol, including environmentally relevant concentrations, on reproduction after exposure during embryo-larval-, juvenile- and adult-life stages in zebrafish (Danio rerio) , 2004 .
[7] L. Zon,et al. In vivo tracking of T cell development, ablation, and engraftment in transgenic zebrafish. , 2004, Proceedings of the National Academy of Sciences of the United States of America.
[8] Stuart L Schreiber,et al. Chemical suppression of a genetic mutation in a zebrafish model of aortic coarctation , 2004, Nature Biotechnology.
[9] W. Alexander,et al. Suppressor screen in Mpl-/- mice: c-Myb mutation causes supraphysiological production of platelets in the absence of thrombopoietin signaling. , 2004, Proceedings of the National Academy of Sciences of the United States of America.
[10] S. Guo,et al. Linking genes to brain, behavior and neurological diseases: what can we learn from zebrafish? , 2004, Genes, brain, and behavior.
[11] Peter Greaves,et al. First dose of potential new medicines to humans: how animals help , 2004, Nature Reviews Drug Discovery.
[12] R. Armer,et al. Trends in early drug safety. , 2004, Drug news & perspectives.
[13] S. Burgess,et al. Transgenic zebrafish produced by retroviral infection of in vitro-cultured sperm. , 2004, Proceedings of the National Academy of Sciences of the United States of America.
[14] S. Kenwrick,et al. Pilot morpholino screen in Xenopus tropicalis identifies a novel gene involved in head development , 2004, Developmental dynamics : an official publication of the American Association of Anatomists.
[15] Kenji Kobayashi,et al. Morpholino-based gene knockdown screen of novel genes with developmental function in Ciona intestinalis , 2003, Development.
[16] Gabriele Vacun,et al. Zebrafish embryos express an orthologue of HERG and are sensitive toward a range of QT-prolonging drugs inducing severe arrhythmia. , 2003, Toxicology and applied pharmacology.
[17] D. Raible,et al. Developmental differences in susceptibility to neomycin-induced hair cell death in the lateral line neuromasts of zebrafish (Danio rerio) , 2003, Hearing Research.
[18] S. Sivasubbu,et al. Efficient gene delivery and gene expression in zebrafish using the Sleeping Beauty transposon. , 2003, Developmental biology.
[19] A. Amsterdam. Insertional mutagenesis in zebrafish , 2003, Developmental dynamics : an official publication of the American Association of Anatomists.
[20] L. Zon,et al. cdx4 mutants fail to specify blood progenitors and can be rescued by multiple hox genes , 2003, Nature.
[21] U. Langheinrich,et al. Zebrafish: a new model on the pharmaceutical catwalk. , 2003, BioEssays : news and reviews in molecular, cellular and developmental biology.
[22] T. Strachan,et al. Mutations in INVS encoding inversin cause nephronophthisis type 2, linking renal cystic disease to the function of primary cilia and left-right axis determination , 2003, Nature Genetics.
[23] Leonard I. Zon,et al. Cancer genetics and drug discovery in the zebrafish , 2003, Nature Reviews Cancer.
[24] J. Tobert,et al. Lovastatin and beyond: the history of the HMG-CoA reductase inhibitors , 2003, Nature Reviews Drug Discovery.
[25] Jan Kaslin,et al. Modulation of the histaminergic system and behaviour by α‐fluoromethylhistidine in zebrafish , 2003 .
[26] Calum A. MacRae,et al. Drugs That Induce Repolarization Abnormalities Cause Bradycardia in Zebrafish , 2003, Circulation.
[27] A. Rubinstein,et al. Zebrafish: from disease modeling to drug discovery. , 2003, Current opinion in drug discovery & development.
[28] David M Langenau,et al. Myc-Induced T Cell Leukemia in Transgenic Zebrafish , 2003, Science.
[29] M. Keating,et al. Tales of regeneration in zebrafish , 2003, Developmental dynamics : an official publication of the American Association of Anatomists.
[30] M. Kent,et al. The State of the Art of the Zebrafish Model for Toxicology and Toxicologic Pathology Research—Advantages and Current Limitations , 2003, Toxicologic pathology.
[31] M. Keating,et al. Heart Regeneration in Zebrafish , 2002, Science.
[32] R. Myers,et al. Rapid mapping of zebrafish mutations with SNPs and oligonucleotide microarrays. , 2002, Genome research.
[33] Patricia McGrath,et al. Zebrafish: a preclinical model for drug screening. , 2002, Assay and drug development technologies.
[34] M. Fishman,et al. The heartstrings mutation in zebrafish causes heart/fin Tbx5 deficiency syndrome. , 2002, Development.
[35] V. Dzau,et al. Construction of a zebrafish cDNA microarray: gene expression profiling of the zebrafish during development. , 2002, Biochemical and biophysical research communications.
[36] Ki-Young Lee,et al. Cloned zebrafish by nuclear transfer from long-term-cultured cells , 2002, Nature Biotechnology.
[37] R. Plasterk,et al. Target-Selected Inactivation of the Zebrafish rag1 Gene , 2002, Science.
[38] Kathryn E. Crosier,et al. Runx1 is required for zebrafish blood and vessel development and expression of a human RUNX1-CBF2T1 transgene advances a model for studies of leukemogenesis. , 2002, Development.
[39] James F Amatruda,et al. Zebrafish as a cancer model system. , 2002, Cancer cell.
[40] J. Heasman. Morpholino oligos: making sense of antisense? , 2002, Developmental biology.
[41] Mark C. Fishman,et al. Cardiomyopathy in zebrafish due to mutation in an alternatively spliced exon of titin , 2002, Nature Genetics.
[42] John Atherton,et al. Mutations of TTN, encoding the giant muscle filament titin, cause familial dilated cardiomyopathy , 2002, Nature Genetics.
[43] M. Fishman,et al. Gridlock signalling pathway fashions the first embryonic artery , 2001, Nature.
[44] T. Schilling,et al. Origins of anteroposterior patterning and Hox gene regulation during chordate evolution. , 2001, Philosophical transactions of the Royal Society of London. Series B, Biological sciences.
[45] John E. Dowling,et al. Behavioral screening for cocaine sensitivity in mutagenized zebrafish , 2001, Proceedings of the National Academy of Sciences of the United States of America.
[46] H O Villar,et al. Toward the design of chemical libraries for mass screening biased against mutagenic compounds. , 2001, Journal of medicinal chemistry.
[47] Cornelia M. van Duijn,et al. A mutation in SLC11A3 is associated with autosomal dominant hemochromatosis , 2001, Nature Genetics.
[48] M. Halpern,et al. Genetic Analysis of Digestive Physiology Using Fluorescent Phospholipid Reporters , 2001, Science.
[49] S. Ekker,et al. Effective targeted gene ‘knockdown’ in zebrafish , 2000, Nature Genetics.
[50] J. Hendricks,et al. Neoplasia in Zebrafish (Danio rerio) Treated with 7,12-Diniethylbenz[a]anthracene by Two Exposure Routes at Different Developmental Stages , 2000, Toxicologic pathology.
[51] M. Fishman,et al. gridlock, an HLH gene required for assembly of the aorta in zebrafish. , 2000, Science.
[52] A. Brownlie,et al. Positional cloning of zebrafish ferroportin1 identifies a conserved vertebrate iron exporter , 2000, Nature.
[53] William A. Harris,et al. Genetic Disorders of Vision Revealed by a Behavioral Screen of 400 Essential Loci in Zebrafish , 1999, The Journal of Neuroscience.
[54] H. Baier,et al. A radiation hybrid map of the zebrafish genome , 1999, Nature Genetics.
[55] J. Postlethwait,et al. Radiation hybrid mapping of the zebrafish genome. , 1999, Proceedings of the National Academy of Sciences of the United States of America.
[56] B. Paw,et al. Characterization of whole genome radiation hybrid mapping resources for non-mammalian vertebrates. , 1998, Nucleic acids research.
[57] Rainer W Friedrich,et al. Genetic Analysis of Vertebrate Sensory Hair Cell Mechanosensation: the Zebrafish Circler Mutants , 1998, Neuron.
[58] J. Dowling,et al. A dominant form of inherited retinal degeneration caused by a non-photoreceptor cell-specific mutation. , 1997, Proceedings of the National Academy of Sciences of the United States of America.
[59] J. Eisen,et al. Zebrafish Make a Big Splash , 1996, Cell.
[60] A. Schier,et al. A genetic screen for mutations affecting embryogenesis in zebrafish. , 1996, Development.
[61] D A Kane,et al. The identification of genes with unique and essential functions in the development of the zebrafish, Danio rerio. , 1996, Development.
[62] A. Schier,et al. Mutations affecting development of the zebrafish retina. , 1996, Development.
[63] E. Green,et al. A molecular basis for cardiac arrhythmia: HERG mutations cause long QT syndrome , 1995, Cell.
[64] A. Schier,et al. Efficient recovery of ENU-induced mutations from the zebrafish germline. , 1994, Genetics.
[65] J. Robson,et al. Recent Advances in Pharmacology , 1951, Canadian Medical Association journal.
[66] J. Clader. The discovery of ezetimibe: a view from outside the receptor. , 2004, Journal of medicinal chemistry.
[67] E. Levin,et al. Chlorpyrifos exposure of developing zebrafish: effects on survival and long-term effects on response latency and spatial discrimination. , 2003, Neurotoxicology and teratology.
[68] M. Lindsay. Target discovery , 2003, Nature Reviews Drug Discovery.
[69] Stephen H. Friend,et al. Toxicogenomics and drug discovery: will new technologies help us produce better drugs? , 2002, Nature Reviews Drug Discovery.
[70] M. Fishman,et al. From Zebrafish to human: modular medical models. , 2002, Annual review of genomics and human genetics.
[71] H. Takeda,et al. Transgenic zebrafish for detecting mutations caused by compounds in aquatic environments , 2000, Nature Biotechnology.
[72] Shuo Lin,et al. Chapter 7 Transgenesis , 1998 .
[73] David I. Wilson,et al. Holt-Oram syndrome is caused by mutations in TBX5, a member of the Brachyury (T) gene family , 1997, Nature Genetics.
[74] A. Schier,et al. Mutations affecting development of the zebrafish ear. , 1996, Development.
[75] Luquan Wang,et al. Materials and Methods Figs. S1 to S4 Tables S1 and S2 References Niemann-pick C1 like 1 Protein Is Critical for Intestinal Cholesterol Absorption , 2022 .