In vivo drug discovery in the zebrafish

[1]  Clayton M. Christensen The Innovator's Dilemma: When New Technologies Cause Great Firms to Fail , 2013 .

[2]  L. Zon,et al.  Effects of lethal irradiation in zebrafish and rescue by hematopoietic cell transplantation. , 2004, Blood.

[3]  Nancy Hopkins,et al.  Identification of 315 genes essential for early zebrafish development. , 2004, Proceedings of the National Academy of Sciences of the United States of America.

[4]  Mark S. Miller,et al.  A genetic screen in zebrafish identifies cilia genes as a principal cause of cystic kidney , 2004, Development.

[5]  J. Fetcho,et al.  Cyclic AMP-Induced Repair of Zebrafish Spinal Circuits , 2004, Science.

[6]  C. Tyler,et al.  Impacts of 17β-estradiol, including environmentally relevant concentrations, on reproduction after exposure during embryo-larval-, juvenile- and adult-life stages in zebrafish (Danio rerio) , 2004 .

[7]  L. Zon,et al.  In vivo tracking of T cell development, ablation, and engraftment in transgenic zebrafish. , 2004, Proceedings of the National Academy of Sciences of the United States of America.

[8]  Stuart L Schreiber,et al.  Chemical suppression of a genetic mutation in a zebrafish model of aortic coarctation , 2004, Nature Biotechnology.

[9]  W. Alexander,et al.  Suppressor screen in Mpl-/- mice: c-Myb mutation causes supraphysiological production of platelets in the absence of thrombopoietin signaling. , 2004, Proceedings of the National Academy of Sciences of the United States of America.

[10]  S. Guo,et al.  Linking genes to brain, behavior and neurological diseases: what can we learn from zebrafish? , 2004, Genes, brain, and behavior.

[11]  Peter Greaves,et al.  First dose of potential new medicines to humans: how animals help , 2004, Nature Reviews Drug Discovery.

[12]  R. Armer,et al.  Trends in early drug safety. , 2004, Drug news & perspectives.

[13]  S. Burgess,et al.  Transgenic zebrafish produced by retroviral infection of in vitro-cultured sperm. , 2004, Proceedings of the National Academy of Sciences of the United States of America.

[14]  S. Kenwrick,et al.  Pilot morpholino screen in Xenopus tropicalis identifies a novel gene involved in head development , 2004, Developmental dynamics : an official publication of the American Association of Anatomists.

[15]  Kenji Kobayashi,et al.  Morpholino-based gene knockdown screen of novel genes with developmental function in Ciona intestinalis , 2003, Development.

[16]  Gabriele Vacun,et al.  Zebrafish embryos express an orthologue of HERG and are sensitive toward a range of QT-prolonging drugs inducing severe arrhythmia. , 2003, Toxicology and applied pharmacology.

[17]  D. Raible,et al.  Developmental differences in susceptibility to neomycin-induced hair cell death in the lateral line neuromasts of zebrafish (Danio rerio) , 2003, Hearing Research.

[18]  S. Sivasubbu,et al.  Efficient gene delivery and gene expression in zebrafish using the Sleeping Beauty transposon. , 2003, Developmental biology.

[19]  A. Amsterdam Insertional mutagenesis in zebrafish , 2003, Developmental dynamics : an official publication of the American Association of Anatomists.

[20]  L. Zon,et al.  cdx4 mutants fail to specify blood progenitors and can be rescued by multiple hox genes , 2003, Nature.

[21]  U. Langheinrich,et al.  Zebrafish: a new model on the pharmaceutical catwalk. , 2003, BioEssays : news and reviews in molecular, cellular and developmental biology.

[22]  T. Strachan,et al.  Mutations in INVS encoding inversin cause nephronophthisis type 2, linking renal cystic disease to the function of primary cilia and left-right axis determination , 2003, Nature Genetics.

[23]  Leonard I. Zon,et al.  Cancer genetics and drug discovery in the zebrafish , 2003, Nature Reviews Cancer.

[24]  J. Tobert,et al.  Lovastatin and beyond: the history of the HMG-CoA reductase inhibitors , 2003, Nature Reviews Drug Discovery.

[25]  Jan Kaslin,et al.  Modulation of the histaminergic system and behaviour by α‐fluoromethylhistidine in zebrafish , 2003 .

[26]  Calum A. MacRae,et al.  Drugs That Induce Repolarization Abnormalities Cause Bradycardia in Zebrafish , 2003, Circulation.

[27]  A. Rubinstein,et al.  Zebrafish: from disease modeling to drug discovery. , 2003, Current opinion in drug discovery & development.

[28]  David M Langenau,et al.  Myc-Induced T Cell Leukemia in Transgenic Zebrafish , 2003, Science.

[29]  M. Keating,et al.  Tales of regeneration in zebrafish , 2003, Developmental dynamics : an official publication of the American Association of Anatomists.

[30]  M. Kent,et al.  The State of the Art of the Zebrafish Model for Toxicology and Toxicologic Pathology Research—Advantages and Current Limitations , 2003, Toxicologic pathology.

[31]  M. Keating,et al.  Heart Regeneration in Zebrafish , 2002, Science.

[32]  R. Myers,et al.  Rapid mapping of zebrafish mutations with SNPs and oligonucleotide microarrays. , 2002, Genome research.

[33]  Patricia McGrath,et al.  Zebrafish: a preclinical model for drug screening. , 2002, Assay and drug development technologies.

[34]  M. Fishman,et al.  The heartstrings mutation in zebrafish causes heart/fin Tbx5 deficiency syndrome. , 2002, Development.

[35]  V. Dzau,et al.  Construction of a zebrafish cDNA microarray: gene expression profiling of the zebrafish during development. , 2002, Biochemical and biophysical research communications.

[36]  Ki-Young Lee,et al.  Cloned zebrafish by nuclear transfer from long-term-cultured cells , 2002, Nature Biotechnology.

[37]  R. Plasterk,et al.  Target-Selected Inactivation of the Zebrafish rag1 Gene , 2002, Science.

[38]  Kathryn E. Crosier,et al.  Runx1 is required for zebrafish blood and vessel development and expression of a human RUNX1-CBF2T1 transgene advances a model for studies of leukemogenesis. , 2002, Development.

[39]  James F Amatruda,et al.  Zebrafish as a cancer model system. , 2002, Cancer cell.

[40]  J. Heasman Morpholino oligos: making sense of antisense? , 2002, Developmental biology.

[41]  Mark C. Fishman,et al.  Cardiomyopathy in zebrafish due to mutation in an alternatively spliced exon of titin , 2002, Nature Genetics.

[42]  John Atherton,et al.  Mutations of TTN, encoding the giant muscle filament titin, cause familial dilated cardiomyopathy , 2002, Nature Genetics.

[43]  M. Fishman,et al.  Gridlock signalling pathway fashions the first embryonic artery , 2001, Nature.

[44]  T. Schilling,et al.  Origins of anteroposterior patterning and Hox gene regulation during chordate evolution. , 2001, Philosophical transactions of the Royal Society of London. Series B, Biological sciences.

[45]  John E. Dowling,et al.  Behavioral screening for cocaine sensitivity in mutagenized zebrafish , 2001, Proceedings of the National Academy of Sciences of the United States of America.

[46]  H O Villar,et al.  Toward the design of chemical libraries for mass screening biased against mutagenic compounds. , 2001, Journal of medicinal chemistry.

[47]  Cornelia M. van Duijn,et al.  A mutation in SLC11A3 is associated with autosomal dominant hemochromatosis , 2001, Nature Genetics.

[48]  M. Halpern,et al.  Genetic Analysis of Digestive Physiology Using Fluorescent Phospholipid Reporters , 2001, Science.

[49]  S. Ekker,et al.  Effective targeted gene ‘knockdown’ in zebrafish , 2000, Nature Genetics.

[50]  J. Hendricks,et al.  Neoplasia in Zebrafish (Danio rerio) Treated with 7,12-Diniethylbenz[a]anthracene by Two Exposure Routes at Different Developmental Stages , 2000, Toxicologic pathology.

[51]  M. Fishman,et al.  gridlock, an HLH gene required for assembly of the aorta in zebrafish. , 2000, Science.

[52]  A. Brownlie,et al.  Positional cloning of zebrafish ferroportin1 identifies a conserved vertebrate iron exporter , 2000, Nature.

[53]  William A. Harris,et al.  Genetic Disorders of Vision Revealed by a Behavioral Screen of 400 Essential Loci in Zebrafish , 1999, The Journal of Neuroscience.

[54]  H. Baier,et al.  A radiation hybrid map of the zebrafish genome , 1999, Nature Genetics.

[55]  J. Postlethwait,et al.  Radiation hybrid mapping of the zebrafish genome. , 1999, Proceedings of the National Academy of Sciences of the United States of America.

[56]  B. Paw,et al.  Characterization of whole genome radiation hybrid mapping resources for non-mammalian vertebrates. , 1998, Nucleic acids research.

[57]  Rainer W Friedrich,et al.  Genetic Analysis of Vertebrate Sensory Hair Cell Mechanosensation: the Zebrafish Circler Mutants , 1998, Neuron.

[58]  J. Dowling,et al.  A dominant form of inherited retinal degeneration caused by a non-photoreceptor cell-specific mutation. , 1997, Proceedings of the National Academy of Sciences of the United States of America.

[59]  J. Eisen,et al.  Zebrafish Make a Big Splash , 1996, Cell.

[60]  A. Schier,et al.  A genetic screen for mutations affecting embryogenesis in zebrafish. , 1996, Development.

[61]  D A Kane,et al.  The identification of genes with unique and essential functions in the development of the zebrafish, Danio rerio. , 1996, Development.

[62]  A. Schier,et al.  Mutations affecting development of the zebrafish retina. , 1996, Development.

[63]  E. Green,et al.  A molecular basis for cardiac arrhythmia: HERG mutations cause long QT syndrome , 1995, Cell.

[64]  A. Schier,et al.  Efficient recovery of ENU-induced mutations from the zebrafish germline. , 1994, Genetics.

[65]  J. Robson,et al.  Recent Advances in Pharmacology , 1951, Canadian Medical Association journal.

[66]  J. Clader The discovery of ezetimibe: a view from outside the receptor. , 2004, Journal of medicinal chemistry.

[67]  E. Levin,et al.  Chlorpyrifos exposure of developing zebrafish: effects on survival and long-term effects on response latency and spatial discrimination. , 2003, Neurotoxicology and teratology.

[68]  M. Lindsay Target discovery , 2003, Nature Reviews Drug Discovery.

[69]  Stephen H. Friend,et al.  Toxicogenomics and drug discovery: will new technologies help us produce better drugs? , 2002, Nature Reviews Drug Discovery.

[70]  M. Fishman,et al.  From Zebrafish to human: modular medical models. , 2002, Annual review of genomics and human genetics.

[71]  H. Takeda,et al.  Transgenic zebrafish for detecting mutations caused by compounds in aquatic environments , 2000, Nature Biotechnology.

[72]  Shuo Lin,et al.  Chapter 7 Transgenesis , 1998 .

[73]  David I. Wilson,et al.  Holt-Oram syndrome is caused by mutations in TBX5, a member of the Brachyury (T) gene family , 1997, Nature Genetics.

[74]  A. Schier,et al.  Mutations affecting development of the zebrafish ear. , 1996, Development.

[75]  Luquan Wang,et al.  Materials and Methods Figs. S1 to S4 Tables S1 and S2 References Niemann-pick C1 like 1 Protein Is Critical for Intestinal Cholesterol Absorption , 2022 .