The N-glycosidase mechanism of ribosome-inactivating proteins implied by crystal structures of alpha-momorcharin.

[1]  Daniel E. Koshland,et al.  STEREOCHEMISTRY AND THE MECHANISM OF ENZYMATIC REACTIONS , 1953 .

[2]  J. Kraut,et al.  Refinement of the crystal structure of adenosine‐5'‐phosphate , 1963 .

[3]  D. Phillips,et al.  The three-dimensional structure of an enzyme molecule. , 1966, Scientific American.

[4]  M. Sundaralingam,et al.  Conformational analysis of the sugar ring in nucleosides and nucleotides. A new description using the concept of pseudorotation. , 1972, Journal of the American Chemical Society.

[5]  J. Irvin Purification and partial characterization of the antiviral protein from Phytolacca americana which inhibits eukaryotic protein synthesis. , 1975, Archives of biochemistry and biophysics.

[6]  S. Heyningen,et al.  Molecular action of toxins and viruses , 1982 .

[7]  A. Pihl,et al.  Toxic lectins and related proteins , 1982 .

[8]  J. Uhr,et al.  Immunotoxins: a new approach to cancer therapy. , 1983, Science.

[9]  Jones Ta,et al.  Diffraction methods for biological macromolecules. Interactive computer graphics: FRODO. , 1985, Methods in enzymology.

[10]  A. Jimenez,et al.  Plant and fungal protein and glycoprotein toxins inhibiting eukaryote protein synthesis. , 1985, Annual review of microbiology.

[11]  L. Yujuan,et al.  THE COURSE OF THE POLYPEPTIDE CHAIN OF TRICHOSANTHIN MOLECULE , 1986 .

[12]  Z. Xuejun,et al.  Homology of trichosanthin and ricin A chain , 1986, Nature.

[13]  L. Barbieri,et al.  Ribosome‐inactivating proteins up to date , 1986, FEBS letters.

[14]  Keiichi Watanabe,et al.  Involvement of arginine residues in inhibition of protein synthesis by ricin A‐chain , 1986, FEBS letters.

[15]  V. Heyningen,et al.  Error rates in prenatal cystic fibrosis diagnosis , 1986, Nature.

[16]  K. Tsurugi,et al.  Mechanism of action of ricin and related toxic lectins on eukaryotic ribosomes. , 1986, Nucleic acids symposium series.

[17]  B. Svensson,et al.  Chemical modification studies on protein synthesis inhibitor II from barley seeds. Identification of an essential tyrosyl residue , 1986 .

[18]  K. Tsurugi,et al.  The mechanism of action of ricin and related toxic lectins on eukaryotic ribosomes. The site and the characteristics of the modification in 28 S ribosomal RNA caused by the toxins. , 1987, The Journal of biological chemistry.

[19]  J. Mekalanos,et al.  Nucleotide sequence of the Shiga-like toxin genes of Escherichia coli. , 1987, Proceedings of the National Academy of Sciences of the United States of America.

[20]  K. Tsurugi,et al.  RNA N-glycosidase activity of ricin A-chain. Mechanism of action of the toxic lectin ricin on eukaryotic ribosomes. , 1987, The Journal of biological chemistry.

[21]  N. Xuong,et al.  The three-dimensional structure of ricin at 2.8 A. , 1987, The Journal of biological chemistry.

[22]  V. Schramm,et al.  Transition-state structures for N-glycoside hydrolysis of AMP by acid and by AMP nucleosidase in the presence and absence of allosteric activator. , 1987, Biochemistry.

[23]  M. Karplus,et al.  Crystallographic R Factor Refinement by Molecular Dynamics , 1987, Science.

[24]  Barry C. Finzel,et al.  The use of an imaging proportional counter in macromolecular crystallography , 1987 .

[25]  H. Noller,et al.  Interaction of elongation factors EF-G and EF-Tu with a conserved loop in 23S RNA , 1988, Nature.

[26]  H. Berman,et al.  Crystal structure of formycin 5'-phosphate: an explanation for its tight binding to AMP nucleosidase. , 1988, Biochemistry.

[27]  K. Tsurugi,et al.  The RNA N-glycosidase activity of ricin A-chain. The characteristics of the enzymatic activity of ricin A-chain with ribosomes and with rRNA. , 1988, The Journal of biological chemistry.

[28]  J. Mekalanos,et al.  Evidence that glutamic acid 167 is an active-site residue of Shiga-like toxin I. , 1988, Proceedings of the National Academy of Sciences of the United States of America.

[29]  K. Tsurugi,et al.  The site of action of six different ribosome-inactivating proteins from plants on eukaryotic ribosomes: the RNA N-glycosidase activity of the proteins. , 1988, Biochemical and biophysical research communications.

[30]  K. Tsurugi,et al.  The RNA N-glycosidase activity of ricin A-chain. , 1988, Nucleic acids symposium series.

[31]  R. Buderi Row over controversial new AIDS drug. , 1989, Nature.

[32]  A. Frankel,et al.  Role of glutamic acid 177 of the ricin toxin A chain in enzymatic inactivation of ribosomes , 1989, Molecular and cellular biology.

[33]  P. Krieg,et al.  Ribosome inactivation by ricin A chain: a sensitive method to assess the activity of wild‐type and mutant polypeptides. , 1989, The EMBO journal.

[34]  M. McGrath,et al.  GLQ223: an inhibitor of human immunodeficiency virus replication in acutely and chronically infected cells of lymphocyte and mononuclear phagocyte lineage. , 1989, Proceedings of the National Academy of Sciences of the United States of America.

[35]  Jia-huai Wang,et al.  Crystals of α-momorcharin: A new ribosome-inactivating protein , 1990 .

[36]  R. W. Baldwin,et al.  A phase I/II study of trichosanthin treatment of HIV disease. , 1990, AIDS.

[37]  D. Richman,et al.  Inhibition of HIV replication by pokeweed antiviral protein targeted to CD4+ cells by monoclonal antibodies , 1990, Nature.

[38]  J. Kahn,et al.  The safety and pharmacokinetics of GLQ223 in subjects with AIDS and AIDS-related complex: a phase I study. , 1990, AIDS.

[39]  J. Richardson,et al.  Role of arginine 180 and glutamic acid 177 of ricin toxin A chain in enzymatic inactivation of ribosomes , 1990, Molecular and cellular biology.

[40]  P. Mcguire,et al.  Site-directed mutagenesis of ricin A chain Trp 211 to Phe. , 2009, International journal of peptide and protein research.

[41]  Axel T. Brunger,et al.  Extension of molecular replacement: a new search strategy based on Patterson correlation refinement , 1990 .

[42]  J. Robertus,et al.  Site‐directed mutagenesis of ricin A‐chain and implications for the mechanism of action , 1991, Proteins.

[43]  J. Robertus,et al.  Structure of ricin A‐chain at 2.5 Å , 1991, Proteins.

[44]  M. Kimura,et al.  Conserved amino acid residues in ribosome-inactivating proteins from plants. , 1991, Biochimie.

[45]  N. Habuka,et al.  Escherichia coli ribosome is inactivated by Mirabilis antiviral protein which cleaves the N-glycosidic bond at A2660 of 23 S ribosomal RNA. , 1991, Journal of molecular biology.

[46]  P. Shaw,et al.  Cloning of the cDNA of α-momorcharin: a ribosome inactivating protein , 1991 .

[47]  G. Legname,et al.  Single‐chain ribosome inactivating proteins from plants depurinate Escherichia coli 23S ribosomal RNA , 1991, FEBS letters.

[48]  H. Yeung,et al.  Minireview: enzymatic properties of ribosome-inactivating proteins (RIPs) and related toxins. , 1991, Life sciences.

[49]  Z. Feng,et al.  Improved isolation and further characterization of beta-trichosanthin, a ribosome-inactivating and abortifacient protein from tubers of trichosanthes cucumeroides (cucurbitaceae) , 1991 .

[50]  J. Robertus,et al.  Analysis of several key active site residues of ricin A chain by mutagenesis and X-ray crystallography. , 1992, Protein engineering.

[51]  A. Frankel,et al.  Structure of a ricin mutant showing rescue of activity by a noncatalytic residue. , 1992, Biochemistry.

[52]  P. Fitzgerald,et al.  Molecular replacement , 1992 .

[53]  A. Monzingo,et al.  X-ray analysis of substrate analogs in the ricin A-chain active site. , 1992, Journal of molecular biology.