rs2476601 T allele (R620W) defines high-risk PTPN22 type I diabetes-associated haplotypes with preliminary evidence for an additional protective haplotype

[1]  K. Lohman,et al.  Overview of the Rapid Response data , 2009, Genes and Immunity.

[2]  J. Ilonen,et al.  Reduced CD4+T cell activation in children with type 1 diabetes carrying the PTPN22/Lyp 620Trp variant. , 2008, Journal of autoimmunity.

[3]  D. Clayton,et al.  PTPN22 Trp620 Explains the Association of Chromosome 1p13 With Type 1 Diabetes and Shows a Statistical Interaction With HLA Class II Genotypes , 2008, Diabetes.

[4]  N. Bottini,et al.  Further Evidence of a Primary, Causal Association of the PTPN22 620W Variant With Type 1 Diabetes , 2008, Diabetes.

[5]  P. Concannon,et al.  Genetic Variation in PTPN22 Corresponds to Altered Function of T and B Lymphocytes1 , 2007, The Journal of Immunology.

[6]  Simon C. Potter,et al.  Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls , 2007, Nature.

[7]  F. Pociot,et al.  PTPN22 R620W Functional Variant in Type 1 Diabetes and Autoimmunity Related Traits , 2007, Diabetes.

[8]  M. Rewers,et al.  Association of the PTPN22/LYP gene with type 1 diabetes , 2006, Pediatric diabetes.

[9]  P. Concannon,et al.  A Haplotype-Based Analysis of the PTPN22 Locus in Type 1 Diabetes , 2006, Diabetes.

[10]  J. Ilonen,et al.  Lymphoid tyrosine phosphatase (LYP/PTPN22) Arg620Trp variant regulates insulin autoimmunity and progression to type 1 diabetes , 2006, Diabetologia.

[11]  K. Eguchi,et al.  Systematic search for single nucleotide polymorphisms in a lymphoid tyrosine phosphatase gene (PTPN22): Association between a promoter polymorphism and type 1 diabetes in Asian populations , 2006 .

[12]  Nunzio Bottini,et al.  Autoimmune-associated lymphoid tyrosine phosphatase is a gain-of-function variant , 2005, Nature Genetics.

[13]  Annette Lee,et al.  Analysis of Families in the Multiple Autoimmune Disease Genetics Consortium (madgc) Collection: the Ptpn22 620w Allele Associates with Multiple Autoimmune Phenotypes , 2022 .

[14]  J. She,et al.  Genetic association between a lymphoid tyrosine phosphatase (PTPN22) and type 1 diabetes. , 2005, Diabetes.

[15]  T. Hudson,et al.  Confirmation of the association of the R620W polymorphism in the protein tyrosine phosphatase PTPN22 with type 1 diabetes in a family based study , 2005, Journal of Medical Genetics.

[16]  Mark Daly,et al.  Haploview: analysis and visualization of LD and haplotype maps , 2005, Bioinform..

[17]  R. Quinton,et al.  The codon 620 tryptophan allele of the lymphoid tyrosine phosphatase (LYP) gene is a major determinant of Graves' disease. , 2004, The Journal of clinical endocrinology and metabolism.

[18]  Adrian Vella,et al.  Replication of an association between the lymphoid tyrosine phosphatase locus (LYP/PTPN22) with type 1 diabetes, and evidence for its role as a general autoimmunity locus. , 2004, Diabetes.

[19]  Kristin G Ardlie,et al.  Genetic association of the R620W polymorphism of protein tyrosine phosphatase PTPN22 with human SLE. , 2004, American journal of human genetics.

[20]  Steven J. Schrodi,et al.  A missense single-nucleotide polymorphism in a gene encoding a protein tyrosine phosphatase (PTPN22) is associated with rheumatoid arthritis. , 2004, American journal of human genetics.

[21]  Nunzio Bottini,et al.  A functional variant of lymphoid tyrosine phosphatase is associated with type I diabetes , 2004, Nature Genetics.

[22]  J. Visvader,et al.  Bfk: a novel weakly proapoptotic member of the Bcl-2 protein family with a BH3 and a BH2 region , 2003, Cell Death and Differentiation.

[23]  J. Cloutier,et al.  Cooperative Inhibition of  T-Cell Antigen Receptor Signaling by a Complex between a Kinase and a Phosphatase , 1999, The Journal of experimental medicine.

[24]  G. Thomson Mapping disease genes: family-based association studies. , 1995, American journal of human genetics.

[25]  K. Mossman The Wellcome Trust Case Control Consortium, U.K. , 2008 .

[26]  J. She,et al.  Genetic Association Between a Lymphoid Tyrosine Phosphatase ( PTPN 22 ) and Type 1 Diabetes , 2005 .

[27]  N. Bottini,et al.  Association of the single nucleotide polymorphism C1858T of the PTPN22 gene with type 1 diabetes. , 2005, Human immunology.

[28]  G. Abecasis,et al.  Merlin—rapid analysis of dense genetic maps using sparse gene flow trees , 2002, Nature Genetics.