Clinical significance of controlling nutritional status (CONUT) in patients with colorectal cancer

Objective ： To clarify the clinical significance of the preoperative Controlling Nutritional Status （ CONUT ） score in patients with colorectal cancer, this study was conducted ． Patients and Method ： The CONUT cutoff value was obtained based on the relationship to the incidence of surgical site infection （ SSI ） in 351 patients who underwent colorectal cancer resection using the Receiver operating characteristic curve （ ROC curve ）． Further, the relationship of CONUT and the 5 - year survival rate was also analyzed ． Results ： As the SSI incidence （ Grade II or higher ） was 9.1 ％（ 32 cases ）， the CONUT cutoff value was 3.0 （ AUC ； 0.66, sensitivity 63 ％， specificity 74 ％， 95 ％ CI ： 0.54 - 0.76 ）． In patients with CONUT ＞ 3.0, the 5 - year survival rate was 38.5 ％， which was significantly lower than the 78.4 ％ rate in patients with CONUT ≦ 3.0 （＜ 0.001 ）． Conclusion ： In colorectal cancer patients with preoperative CONUT ＞ 3.0, the SSI incidence was high and the prognosis was poor. These results suggest that a study to evaluate malnu-tritional status of patients using CONUT is necessary to determine whether nutritional in-tervention can improve the incidence of SSI and prognosis ． controlling nutritional status（CONUT），surgical site