Depression and Parkinson’s Disease: Current Knowledge

Depressive disturbances are common in patients with Parkinson’s disease (PD) and influence many other clinical aspects of the disease. In addition to causing inherent emotional distress, depressive disorders negatively impact quality of life, motor and cognitive deficits, functional disability, and other psychiatric comorbidities in patients with PD. Knowledge of the pathophysiology of PD depression remains limited. However, clinical studies demonstrate the efficacy of medications and psychotherapies for PD depression, underscoring the importance of their timely detection and concerted management.

[1]  M. Merello,et al.  Depression in classic versus akinetic‐rigid Parkinson's disease , 1998, Movement disorders : official journal of the Movement Disorder Society.

[2]  S. Grill,et al.  Psychiatric comorbidities in patients with Parkinson disease and psychosis , 2004, Neurology.

[3]  J. Mink,et al.  Clinical features and comorbidity of mood fluctuations in Parkinson's disease. , 2002, The Journal of neuropsychiatry and clinical neurosciences.

[4]  J. Jankovic,et al.  The impact of depressive symptoms in early Parkinson disease , 2007, Neurology.

[5]  A. Leentjens.  The Role of Dopamine Agonists in the Treatment of Depression in Patients with Parkinson’s Disease , 2011, Drugs.

[6]  D. Aarsland,et al.  Neuropsychiatric Symptoms in Parkinson's Disease. , 2015, Journal of Parkinson's disease.

[7]  B. Bloem,et al.  Effectiveness of multidisciplinary care for Parkinson's disease: A randomized, controlled trial , 2013, Movement disorders : official journal of the Movement Disorder Society.

[8]  D. Denys,et al.  Deep brain stimulation for obsessive–compulsive disorders: long-term analysis of quality of life , 2013, Journal of Neurology, Neurosurgery & Psychiatry.

[9]  K. Cook,et al.  Telephone-Administered Cognitive Behavioral Therapy: A Case Study of Anxiety and Depression in Parkinson’s Disease , 2009, Journal of Clinical Psychology in Medical Settings.

[10]  Matthew Menza,et al.  Barriers to Mental Health Care Utilization in Parkinson’s Disease , 2013, Journal of geriatric psychiatry and neurology.

[11]  H. Mayberg,et al.  Selective hypometabolism in the inferior frontal lobe in depressed patients with Parkinson's disease , 1990, Annals of neurology.

[12]  F. Binkofski,et al.  Nonmotor symptoms in genetic Parkinson disease. , 2010, Archives of neurology.

[13]  M. Nirenberg,et al.  Dopamine agonist withdrawal syndrome in Parkinson disease. , 2010, Archives of neurology.

[14]  N. Kovács,et al.  The impact of left prefrontal repetitive transcranial magnetic stimulation on depression in Parkinson's disease: A randomized, double‐blind, placebo‐controlled study , 2010, Movement disorders : official journal of the Movement Disorder Society.

[15]  T. Ten Have,et al.  Suicidal and death ideation in Parkinson's disease , 2008, Movement disorders : official journal of the Movement Disorder Society.

[16]  M. Buszewicz,et al.  Clinical effectiveness of individual cognitive behavioral therapy for depressed older people in primary care: a randomized controlled trial. , 2009, Archives of general psychiatry.

[17]  S. Buyske,et al.  The impact of treatment of depression on quality of life, disability and relapse in patients with Parkinson's disease , 2009, Movement disorders : official journal of the Movement Disorder Society.

[18]  D. Maraganore,et al.  Increased risk of depressive and anxiety disorders in relatives of patients with Parkinson disease. , 2007, Archives of general psychiatry.

[19]  M. Garolera,et al.  Depression in Parkinson's disease: clinical correlates and outcome. , 2003, Parkinsonism & related disorders.

[20]  T. Nagatsu,et al.  The relationship between depression and regional cerebral blood flow in Parkinson’s disease and the effect of selegiline treatment , 2011, Acta neurologica Scandinavica.

[21]  L. Defebvre,et al.  Comparison of desipramine and citalopram treatments for depression in Parkinson's disease: A double‐blind, randomized, placebo‐controlled study , 2008, Movement disorders : official journal of the Movement Disorder Society.

[22]  I. Tendolkar,et al.  Prevalence of depression in Parkinson's disease: Effects of disease stage, motor subtype and gender , 2011, Journal of the Neurological Sciences.

[23]  P. Silburn,et al.  Serotonin and dopamine transporter genes do not influence depression in Parkinson's disease , 2009, Movement disorders : official journal of the Movement Disorder Society.

[24]  L. Wilkins.  Phenotype in parkinsonian and nonparkinsonian LRRK2 G2019S mutation carriers , 2011, Neurology.

[25]  A. Singleton,et al.  Meeting Report: Consensus Statement—Parkinson’s Disease and the Environment: Collaborative on Health and the Environment and Parkinson’s Action Network (CHE PAN) Conference 26–28 June 2007 , 2008, Environmental health perspectives.

[26]  C. Brayne,et al.  A systematic review of depression and mental illness preceding Parkinson's disease , 2006, Acta neurologica Scandinavica.

[27]  R. Marconi,et al.  Pramipexole versus sertraline in the treatment of depression in Parkinson’s disease , 2006, Journal of Neurology.

[28]  P. Chan,et al.  No association between polymorphism of serotonin transporter gene and depression in Parkinson's disease in Chinese , 2009, Neuroscience Letters.

[29]  H. Mayberg,et al.  Cognitive impairments and depression in Parkinson's disease: a follow up study. , 1990, Journal of neurology, neurosurgery, and psychiatry.

[30]  C. Tanner,et al.  Serotonin syndrome and the combined use of deprenyl and an antidepressant in Parkinson's disease , 1997, Neurology.

[31]  K. Marder,et al.  The relation between depression and parkin genotype: the CORE-PD study. , 2011, Parkinsonism & related disorders.

[32]  Felipe Fregni,et al.  Effect of repetitive TMS and fluoxetine on cognitive function in patients with Parkinson's disease and concurrent depression , 2005, Movement disorders : official journal of the Movement Disorder Society.

[33]  R. Beninger,et al.  Depressive Symptoms in Parkinson's Disease: A Comparison With Disabled Control Subjects , 1990, Journal of geriatric psychiatry and neurology.

[34]  Fabrizio Stocchi,et al.  Factors impacting on quality of life in Parkinson's disease: Results from an international survey , 2002, Movement disorders : official journal of the Movement Disorder Society.

[35]  R. Mindham,et al.  Mortality in Parkinson's disease and its association with dementia and depression , 2004, Acta neurologica Scandinavica.

[36]  M. Mark,et al.  Telephone-Based Cognitive–Behavioral Therapy for Depression in Parkinson Disease , 2011, Journal of geriatric psychiatry and neurology.

[37]  A. Tröster,et al.  The impact of antidepressant treatment on cognitive functioning in depressed patients with Parkinson's disease. , 2010, The Journal of neuropsychiatry and clinical neurosciences.

[38]  I. Katz,et al.  Striatal dopamine transporter imaging correlates with anxiety and depression symptoms in Parkinson's disease. , 2005, Journal of nuclear medicine : official publication, Society of Nuclear Medicine.

[39]  R. Munhoz,et al.  Depression in Parkinson's disease: a double-blind, randomized, placebo-controlled pilot study of omega-3 fatty-acid supplementation. , 2008, Journal of affective disorders.

[40]  D. Mohr,et al.  Telephone-administered cognitive-behavioral therapy for the treatment of depressive symptoms in multiple sclerosis. , 2000, Journal of consulting and clinical psychology.

[41]  D. Brooks,et al.  Depressive symptoms in PD correlate with higher 5-HTT binding in raphe and limbic structures , 2010, Neurology.

[42]  M. Oda,et al.  Minor depression and brain perfusion images in Parkinson's disease , 2006, Movement disorders : official journal of the Movement Disorder Society.

[43]  G. Lewis,et al.  Efficacy and acceptability of selective serotonin reuptake inhibitors for the treatment of depression in Parkinson's disease: a systematic review and meta-analysis of randomized controlled trials , 2010, BMC neurology.

[44]  P. Rabins,et al.  A comparison of nine scales to detect depression in Parkinson disease , 2012, Neurology.

[45]  R. Lousberg,et al.  Markers for depression in Parkinson's disease , 2002, Acta psychiatrica Scandinavica.

[46]  P. Riederer,et al.  Allelic variation of serotonin transporter expression is associated with depression in Parkinson's disease , 2001, Molecular Psychiatry.

[47]  Werner Poewe,et al.  A double-blind, delayed-start trial of rasagiline in Parkinson's disease. , 2009, The New England journal of medicine.

[48]  M. Mark,et al.  Cognitive-behavioral therapy for depression in Parkinson's disease: a randomized, controlled trial. , 2011, The American journal of psychiatry.

[49]  Faith M. Gunning-Dixon,et al.  Executive Dysfunction and the Course of Geriatric Depression , 2005, Biological Psychiatry.

[50]  K. Dujardin,et al.  Anxiety and motor fluctuations in Parkinson's disease: a cross-sectional observational study. , 2012, Parkinsonism & related disorders.

[51]  W. Weiner,et al.  Non-recognition of depression and other non-motor symptoms in Parkinson's disease. , 2002, Parkinsonism & related disorders.

[52]  H. Tenenbaum,et al.  Depression in Parkinson’s disease: Health risks, etiology, and treatment options , 2008, Neuropsychiatric disease and treatment.

[53]  P. Bain,et al.  Randomized, double‐blind, 3‐month parallel study of the effects of pramipexole, pergolide, and placebo on parkinsonian tremor , 2003, Movement disorders : official journal of the Movement Disorder Society.

[54]  Paul E Holtzheimer,et al.  Deep brain stimulation for psychiatric disorders. , 2011, Annual review of neuroscience.

[55]  M. Trimble,et al.  Electroconvulsive therapy in Parkinson's disease and other movement disorders , 1991, Movement disorders : official journal of the Movement Disorder Society.

[56]  A. Siderowf,et al.  Tricyclic antidepressants delay the need for dopaminergic therapy in early Parkinson's disease , 2012, Movement disorders : official journal of the Movement Disorder Society.

[57]  R. Hales,et al.  J Neuropsychiatry Clin Neurosci , 1992 .

[58]  A. Brice,et al.  LRRK2 G2019S mutation in Parkinson's disease: a neuropsychological and neuropsychiatric study in a large Algerian cohort. , 2010, Parkinsonism & related disorders.

[59]  J. Jankovic,et al.  The course of depressive symptoms in early Parkinson's disease , 2009, Movement disorders : official journal of the Movement Disorder Society.

[60]  D. Aarsland,et al.  A systematic review of prevalence studies of depression in Parkinson's disease , 2008, Movement disorders : official journal of the Movement Disorder Society.

[61]  Y. Temel,et al.  Serotonin-dependent depression in Parkinson’s disease: A role for the subthalamic nucleus? , 2011, Neuropharmacology.

[62]  H. Marín,et al.  Depression in Parkinson's disease: symptom improvement and residual symptoms after acute pharmacologic management. , 2011, The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry.

[63]  R G Robinson,et al.  Depression in Parkinson's Disease , 1990, The Journal of nervous and mental disease.

[64]  H. Mayberg,et al.  Depression in Parkinson's disease: a biochemical and organic viewpoint. , 1995, Advances in neurology.

[65]  S. Fox,et al.  The serotonergic system in motor and non-motor manifestations of Parkinson’s disease , 2013, Experimental Brain Research.

[66]  H. Mayberg,et al.  A prospective longitudinal study of depression, cognitive decline, and physical impairments in patients with Parkinson's disease. , 1992, Journal of neurology, neurosurgery, and psychiatry.

[67]  J. Sage,et al.  Depression and Anxiety in Parkinson's Disease: Possible Effect of Genetic Variation in the Serotonin Transporter , 1999, Journal of geriatric psychiatry and neurology.

[68]  W. Weiner,et al.  Quality improvement in neurology: AAN Parkinson disease quality measures , 2010, Neurology.

[69]  Y. Agid,et al.  Acute severe depression induced by intraoperative stimulation of the substantia nigra: a case report. , 2008, Parkinsonism & related disorders.

[70]  K. Lyons,et al.  Ropinirole 24-hour prolonged release , 2007, Neurology.

[71]  William W. McDonald,et al.  Provisional diagnostic criteria for depression in Parkinson's disease: Report of an NINDS/NIMH Work Group , 2006, Movement disorders : official journal of the Movement Disorder Society.

[72]  R. Robinson,et al.  A validation study of depressive syndromes in Parkinson's disease , 2008, Movement disorders : official journal of the Movement Disorder Society.

[73]  L. Marsh,et al.  Cognitive behavioral therapy for depression and anxiety in Parkinson's disease: a clinical review. , 2012, Journal of Parkinson's disease.

[74]  D. Burn,et al.  Parkinson's disease: The quintessential neuropsychiatric disorder , 2011, Movement disorders : official journal of the Movement Disorder Society.

[75]  Birk Engmann.  Bipolar Affective Disorder and Parkinson's Disease , 2011, Case reports in medicine.

[76]  C. Christine,et al.  A randomized, double-blind, placebo-controlled trial of antidepressants in Parkinson disease , 2012, Neurology.

[77]  D. Burn,et al.  Allelic variation of a functional polymorphism in the serotonin transporter gene and depression in Parkinson's disease. , 2006, Parkinsonism & related disorders.

[78]  C. Marsden,et al.  Depression and disability in Parkinson's disease: a follow-up of 132 cases , 1988, Psychological Medicine.

[79]  M Filippi,et al.  Regional patterns of brain tissue loss associated with depression in Parkinson disease , 2010, Neurology.

[80]  J. Ballenger.  Repetitive Transcranial Magnetic Stimulation Is as Effective as Fluoxetine in the Treatment of Depression in Patients With Parkinson's Disease , 2006 .

[81]  T. Egberts,et al.  Influence of initial use of serotonergic antidepressants on antiparkinsonian drug use in levodopa-using patients , 2007, European Journal of Clinical Pharmacology.

[82]  N. H. Rod,et al.  Major life events and development of major depression in Parkinson's disease patients , 2013, European journal of neurology.

[83]  Dag Aarsland,et al.  Depression in Parkinson disease—epidemiology, mechanisms and management , 2011, Nature Reviews Neurology.

[84]  Kenichi Komatsu,et al.  Depression in Parkinson's disease. Diffusion tensor imaging study. , 2007, Journal of neurology.

[85]  Matthew A. Menza,et al.  Parkinson's disease and anxiety: Comorbidity with depression , 1993, Biological Psychiatry.

[86]  E. Tolosa,et al.  Pramipexole for the treatment of depressive symptoms in patients with Parkinson's disease: a randomised, double-blind, placebo-controlled trial , 2010, The Lancet Neurology.

[87]  K. Dujardin,et al.  Symptomatology and markers of anxiety disorders in Parkinson's disease: A cross‐sectional study , 2011, Movement disorders : official journal of the Movement Disorder Society.

[88]  M. Martens,et al.  Prevalence, clinical manifestations, etiology, and treatment of depression in Parkinson's disease. , 2001, The Journal of neuropsychiatry and clinical neurosciences.

[89]  M. Fava,et al.  The STAR*D study: Treating depression in the real world INTERPRETING KEY TRIALS , 2007 .

[90]  W. Poewe,et al.  The Movement Disorder Society Evidence‐Based Medicine Review Update: Treatments for the non‐motor symptoms of Parkinson's disease , 2011, Movement disorders : official journal of the Movement Disorder Society.

[91]  S. Buyske,et al.  A controlled trial of antidepressants in patients with Parkinson disease and depression , 2009, Neurology.

[92]  M. Hotopf,et al.  Antidepressants for the treatment of depression in neurological disorders: a systematic review and meta-analysis of randomised controlled trials , 2011, Journal of Neurology, Neurosurgery & Psychiatry.

[93]  J. Andersen,et al.  Anti‐depressive treatment in Parkinson's disease A CONTROLLED TRIAL OF THE EFFECT OF NORTRIPTYLINE IN PATIENTS WITH PARKINSON'S DISEASE TREATED WITH L‐DOPA , 1980, Acta neurologica Scandinavica.

[94]  Daniel Weintraub,et al.  Recognition and Treatment of Depression in Parkinson's Disease , 2003, Journal of geriatric psychiatry and neurology.

[95]  E. A. D. de Souza,et al.  The effect of psychotherapy in patients with PD: a controlled study. , 2010, Parkinsonism & related disorders.

[96]  J. Assmus,et al.  Importance of motor vs. non-motor symptoms for health-related quality of life in early Parkinson's disease. , 2013, Parkinsonism & related disorders.

[97]  D. Reda,et al.  Suicide ideation and behaviours after STN and GPi DBS surgery for Parkinson’s disease: results from a randomised, controlled trial , 2013, Journal of Neurology, Neurosurgery & Psychiatry.

[98]  N. Bohnen,et al.  Cortical cholinergic denervation is associated with depressive symptoms in Parkinson’s disease and parkinsonian dementia , 2007, Journal of Neurology, Neurosurgery & Psychiatry.

[99]  Dick J Veltman,et al.  Depressive symptoms in Parkinson's disease are related to reduced [123I]FP-CIT binding in the caudate nucleus , 2013, Journal of Neurology, Neurosurgery & Psychiatry.

[100]  J. Velíšková,et al.  Pramipexole and pergolide in the treatment of depression in Parkinson's disease: a national multicentre prospective randomized study , 2003, European journal of neurology.

[101]  P. Pollak,et al.  Transient acute depression induced by high-frequency deep-brain stimulation. , 1999, The New England journal of medicine.

[102]  M. Hely,et al.  Sydney multicenter study of Parkinson's disease: Non‐L‐dopa–responsive problems dominate at 15 years , 2005, Movement disorders : official journal of the Movement Disorder Society.

[103]  K. Chaudhuri,et al.  Non-motor symptoms of Parkinson's disease: diagnosis and management , 2006, The Lancet Neurology.