Central trajectories of type II spiral ganglion neurons

Previous attempts to trace the central pathways of the thin axons from type II spiral ganglion neurons have been hampered by technical difficulties such as fading of the reaction product as distance increases from the injection site (Ryugo et al.: Soc. Neurosci. Abstr. 12:779, '86; Brown: J. Comp. Neurol. 260:591–604, '87). By using small rodents (gerbils and mice), which have short auditory nerves, we have succeeded in filling the entire central axon and terminals of type II neurons after peripheral injections of horseradish peroxidase. The general course of the type II fibers within the auditory nerve and cochlear nucleus is similar to that of type I fibers except that terminals from type II neurons are often found in regions of the cochlear nucleus that have high densities of granule cells.

[1]  Catherine A. Smith.  Innervation of the Cochlea of the Guinea Pig by Use of the Golgi Stain , 1975, The Annals of otology, rhinology, and laryngology.

[2]  L. Thornell,et al.  Cytoskeletal Organization of the Human Inner Ear: II. Characterization of Intermediate Filaments in the Cochlea , 1987 .

[3]  D. Rl.  Some unresolved problems concerning the cochlear nerve. , 1976 .

[4]  R. Gacek,et al.  The Primary Acoustic Nuclei , 1983 .

[5]  D. Ryugo,et al.  Hair cell innervation by spiral ganglion neurons in the mouse , 1987, The Journal of comparative neurology.

[6]  D. K. Morest,et al.  Noise-induced degeneration in the brain and representation of inner and outer hair cells , 1983, Hearing Research.

[7]  H. Spoendlin,et al.  The adrenergic innervation of the labyrinth. , 1966, Acta oto-laryngologica.

[8]  Ramón y Cajal,et al.  Histologie du système nerveux de l'homme & des vertébrés , 1909 .

[9]  N. Kiang,et al.  Hair-cell innervation by spiral ganglion cells in adult cats. , 1982, Science.

[10]  H. Spoendlin.  Neural connections of the outer haircell system. , 1979, Acta oto-laryngologica.

[11]  K. Osen.  Course and termination of the primary afferents in the cochlear nuclei of the cat. An experimental anatomical study. , 1970, Archives italiennes de biologie.

[12]  H. Spokndlin,et al.  The Adrenergic Innervation of the Labyrinth , 1966 .

[13]  J. Brawer,et al.  Projections of the cochlea to the dorsal cochlear nucleus in the cat. , 1972, Experimental neurology.

[14]  E. Perl,et al.  Central projections of identified, unmyelinated (C) afferent fibers innervating mammalian skin. , 1986, Science.

[15]  G. Mogi,et al.  Fine Structures of the Normal Mucosa in Developing Rat Middle Ear , 1976, The Annals of otology, rhinology, and laryngology.

[16]  H. Spoendlin.  Innervation densities of the cochlea. , 1972, Acta oto-laryngologica.

[17]  M. Liberman.  Single-neuron labeling in the cat auditory nerve. , 1982, Science.

[18]  D. K. Morest,et al.  Relations between auditory nerve endings and cell types in the cat's anteroventral cochlear nucleus seen with the Golgi method and nomarski optics , 1975, The Journal of comparative neurology.

[19]  R. de Nó.  Some unresolved problems concerning the cochlear nerve. , 1976, The Annals of otology, rhinology, and laryngology.

[20]  R. Irving,et al.  Second Order Neurons in the Acoustic Nerve , 1962, Science.

[21]  E. Rouiller,et al.  The central projections of intracellularly labeled auditory nerve fibers in cats , 1984, The Journal of comparative neurology.

[22]  M. Liberman,et al.  Afferent innervation of outer hair cells in adult cats: I. Light microscopic analysis of fibers labeled with horseradish peroxidase , 1988, The Journal of comparative neurology.

[23]  J. Adams,et al.  Technical considerations on the use of horseradish peroxidase as a neuronal marker , 1977, Neuroscience.

[24]  M. C. Brown,et al.  Brainstem branches from olivocochlear axons in cats and rodents , 1988, The Journal of comparative neurology.

[25]  D. Ryugo,et al.  Morphology of primary axosomatic endings in the anteroventral cochlear nucleus of the cat: A study of the endbulbs of Held , 1982, The Journal of comparative neurology.

[26]  Enrico Mugnaini,et al.  Distribution and light microscopic features of granule cells in the cochlear nuclei of cat, rat, and mouse , 1980, The Journal of comparative neurology.

[27]  R. Perkins,et al.  A study of cochlear innervation patterns in cats and rats with the Golgi method and Nomarski optics , 1975, The Journal of comparative neurology.

[28]  D. Oliver,et al.  Transganglionic transport of D-aspartate from cochlear nucleus to cochlea a quantitative autoradiographic study , 1984, Hearing Research.

[29]  R. Snyder,et al.  Uptake and transport of horseradish peroxidase by cochlear spiral ganglion neurons , 1982, Hearing Research.

[30]  Brown Mc,et al.  Morphology of labeled afferent fibers in the guinea pig cochlea , 1987, The Journal of comparative neurology.

[31]  M. Ruggero,et al.  Type II cochlear ganglion cells in the chinchilla , 1982, Hearing Research.

[32]  R. Romand,et al.  The ultrastructure of spiral ganglion cells in the mouse. , 1987, Acta oto-laryngologica.

[33]  M. Feldman,et al.  The projection of the acoustic nerve to the ventral cochlear nucleus of the rat. A Golgi study , 1969, The Journal of comparative neurology.

[34]  M. Liberman,et al.  Morphometry of intracellularly labeled neurons of the auditory nerve: Correlations with functional properties , 1984, The Journal of comparative neurology.

[35]  Ear Infirmary.  Brainstem Branches From Olivocochlear Axons in Cats and Rodents , 1988 .

[36]  Raphael Lorente De No,et al.  The Primary Acoustic Nuclei , 1981 .

[38]  Donald Robertson,et al.  Horseradish peroxidase injection of physiologically characterized afferent and efferent neurones in the guinea pig spiral ganglion , 1984, Hearing Research.

[39]  W. Harris,et al.  Lysophosphatidyl choline facilitates labeling of CNS projections with horseradish peroxidase , 1980, Journal of Neuroscience Methods.

[40]  E. Rouiller,et al.  The central projections of intracellularly labeled auditory nerve fibers in cats: an analysis of terminal morphology. , 1986, The Journal of comparative neurology.

[41]  M. C. Brown,et al.  Physiology and anatomy of single olivocochlear neurons in the cat , 1986, Hearing Research.