An overview of the status of imaging screening technology for breast cancer.

With breast cancer incidence rates showing no signs of abating, advances in risk stratification and increasing awareness of cancer control, there is interest in expanding the breast imaging arsenal. Mammography is still the standard of care, and a recent meta-analysis of seven large studies supports its value as a screening tool. There is, however, clear need for improved sensitivity and specificity. Imaging of function, metabolism and molecular activity in breast tissue is of potential benefit in addressing these issues. In this article we provide an overview of the current methods of imaging in breast cancer, including mammography, ultrasound, digital mammography, magnetic resonance, positron emission tomography and magnetic resonance spectroscopy. Screening and surveillance should, ideally, be tailored to an individual's cancer risk and breast tissue. Current evidence questions the recent move toward magnetic resonance imaging as a single or multimodality strategy for breast cancer screening. In a high-risk group, the cost effectiveness of technical innovations may be justified.

[1]  R Holland,et al.  High mammographic breast density and its implications for the early detection of breast cancer , 1999, Journal of medical screening.

[2]  U. Fischer,et al.  MR imaging of mammographically detected clustered microcalcifications: is there any value? , 1998, Radiology.

[3]  D Krebs,et al.  Breast MR imaging screening in 192 women proved or suspected to be carriers of a breast cancer susceptibility gene: preliminary results. , 2000, Radiology.

[4]  Martin O Leach,et al.  Breast imaging technology: Application of magnetic resonance imaging to angiogenesis in breast cancer , 2000, Breast Cancer Research.

[5]  S. Weinstein,et al.  MR imaging of the breast in patients with invasive lobular carcinoma. , 2001, AJR. American journal of roentgenology.

[6]  J O Barentsz,et al.  Breast tumors: comparative accuracy of MR imaging relative to mammography and US for demonstrating extent. , 1995, Radiology.

[7]  Taylor Murray,et al.  Cancer Statistics, 2001 , 2001, CA: a cancer journal for clinicians.

[8]  U. Schmiedl,et al.  Preoperative evaluation of patients awaiting liver transplantation: Comparison of multiphasic contrast‐enhanced 3D magnetic resonance to helical computed tomography examinations , 2002, Journal of magnetic resonance imaging : JMRI.

[9]  B. Grube,et al.  MRI of occult breast carcinoma in a high-risk population , 2004 .

[10]  T. M. Kolb,et al.  Occult cancer in women with dense breasts: detection with screening US--diagnostic yield and tumor characteristics. , 1998, Radiology.

[11]  L. Bassett Digital and Computer‐Aided Mammography , 2000, The breast journal.

[12]  N. Boyd,et al.  The risk of breast cancer associated with mammographic parenchymal patterns: a meta-analysis of the published literature to examine the effect of method of classification. , 1992, Cancer detection and prevention.

[13]  M. Schnall,et al.  MR imaging of ductal carcinoma in situ. , 1997, Radiology.

[14]  J. Talbot,et al.  [18F]FDG in recurrent breast cancer: diagnostic performances, clinical impact and relevance of induced changes in management , 2004, European Journal of Nuclear Medicine and Molecular Imaging.

[15]  P. Sismondi,et al.  Beyond randomized controlled trials , 2002, Cancer.

[16]  M D Schnall,et al.  A combined architectural and kinetic interpretation model for breast MR images. , 2001, Academic radiology.

[17]  L. Liberman,et al.  Breast lesions detected on MR imaging: features and positive predictive value. , 2002, AJR. American journal of roentgenology.

[18]  L. Schwartz,et al.  MR imaging of the breast in patients with occult primary breast carcinoma. , 1997, Radiology.

[19]  A Heinig,et al.  Contrast-enhanced MRI of the breast: accuracy, value, controversies, solutions. , 1997, European journal of radiology.

[20]  Melinda J. Staiger,et al.  Breast cancer measurements with magnetic resonance imaging, ultrasonography, and mammography , 2005, Breast Cancer Research and Treatment.

[21]  S. Seal,et al.  Localization of a breast cancer susceptibility gene, BRCA2, to chromosome 13q12-13. , 1994, Science.

[22]  C. Scott-Conner,et al.  Axillary metastasis from occult breast carcinoma: diagnosis and management. , 1995, The American surgeon.

[23]  L. Liberman,et al.  Probably benign lesions at breast magnetic resonance imaging , 2003, Cancer.

[24]  C. Redmond,et al.  Eight-year Results of a Randomized Clinical Trial Comparing Total Mastectomy and Lumpectomy with or without Irradiation in the Treatment of Breast Cancer , 1989 .

[25]  R. Lenkinski,et al.  Human breast lesions: characterization with proton MR spectroscopy. , 1998, Radiology.

[26]  M D Schnall,et al.  Staging of suspected breast cancer: effect of MR imaging and MR-guided biopsy. , 1995, Radiology.

[27]  R. Lenkinski,et al.  Clinical utility of proton magnetic resonance spectroscopy in characterizing breast lesions. , 2002, Journal of the National Cancer Institute.

[28]  S. Obenauer,et al.  Comparative study in patients with microcalcifications: full-field digital mammography vs screen-film mammography , 2002, European Radiology.

[29]  C. Boetes,et al.  False-negative MR imaging of malignant breast tumors , 1997, European Radiology.

[30]  R Holland,et al.  Effect of mammographic breast density on breast cancer screening performance: a study in Nijmegen, The Netherlands. , 1998, Journal of epidemiology and community health.

[31]  R. Alfidi,et al.  Magnetic resonance imaging of the breast. Work in progress. , 1984, Radiology.

[32]  S. Wall,et al.  Breast cancer screening with mammography: overview of Swedish randomised trials , 1993, The Lancet.

[33]  M. Gail,et al.  Projecting individualized probabilities of developing breast cancer for white females who are being examined annually. , 1989, Journal of the National Cancer Institute.

[34]  W. Kaiser MRM promises earlier breast cancer diagnosis. , 1992, Diagnostic imaging.

[35]  G. P. Krestin,et al.  Detection of breast cancer with conventional mammography and contrast-enhanced MR imaging , 1998, European Radiology.

[36]  X. Sastre,et al.  Presentation of axillary lymphadenopathy without detectable breast primary (T0 N1b breast cancer): experience at Institut Curie. , 1989, Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology.

[37]  Robert E. Lenkinski,et al.  The evaluation of human breast lesions with magnetic resonance imaging and proton magnetic resonance spectroscopy , 2001, Breast Cancer Research and Treatment.

[38]  Edwin Silverberg,et al.  Survival experience in the breast cancer detection demonstration project , 1987, CA: a cancer journal for clinicians.

[39]  D. Fraker,et al.  Breast carcinoma: MR imaging before re-excisional biopsy. , 1997, Radiology.

[40]  M D Schnall,et al.  Suspicious breast lesions: MR imaging with radiologic-pathologic correlation. , 1994, Radiology.

[41]  Peter C Gøtzsche,et al.  Cochrane review on screening for breast cancer with mammography , 2001, The Lancet.

[42]  E. Sj,et al.  Magnetic resonance imaging of the breast. , 1986 .

[43]  Andrew D. A. Maidment,et al.  Image processing algorithms for digital mammography: a pictorial essay. , 2000, Radiographics : a review publication of the Radiological Society of North America, Inc.

[44]  K Offit,et al.  Recommendations for follow-up care of individuals with an inherited predisposition to cancer. II. BRCA1 and BRCA2. Cancer Genetics Studies Consortium. , 1997, JAMA.

[45]  R. Gilles,et al.  Assessment of breast cancer recurrence with contrast-enhanced subtraction MR imaging: preliminary results in 26 patients. , 1993, Radiology.

[46]  J M Pruneda,et al.  MR imaging in the management before surgery of lobular carcinoma of the breast: correlation with pathology. , 1996, AJR. American journal of roentgenology.

[47]  M D Schnall,et al.  MR imaging of the breast for the detection, diagnosis, and staging of breast cancer. , 2001, Radiology.

[48]  C. Kuhl,et al.  Surveillance of "high risk" women with proven or suspected familial (hereditary) breast cancer: First mid-term results of a multi-modality clinical screening trial , 2003 .

[49]  N Risch,et al.  Genetic analysis of breast cancer in the cancer and steroid hormone study. , 1991, American journal of human genetics.

[50]  R Holland,et al.  Mammographically occult breast cancer: A pathologic and radiologic study , 1983, Cancer.

[51]  R. J. Alfidi,et al.  Nuclear magnetic resonance imaging of the human breast , 1984 .

[52]  M. Leach,et al.  Breast imaging technology: Imaging biochemistry - applications to breast cancer , 2000, Breast Cancer Research.

[53]  S. Feig,et al.  Screening for cancer: when is it valid?--Lessons from the mammography experience. , 2003, Radiology.

[54]  Kolb Tm Ultrasound boosts cancer detection in dense breasts. , 2000 .

[55]  P. C. Wang,et al.  Prototype coil for magnetic resonance imaging of the female breast. Work in progress. , 1985, Radiology.

[56]  E. Morris Screening for breast cancer with MRI. , 2003, Seminars in ultrasound, CT, and MR.

[57]  M. Reiser,et al.  MRT-geführte Vakuumbiopsie bei 206 kontrastmittelanreichernden Läsionen der Mamma , 2002 .

[58]  B Fisher,et al.  Eight-year results of a randomized clinical trial comparing total mastectomy and lumpectomy with or without irradiation in the treatment of breast cancer. , 1989, The New England journal of medicine.

[59]  C A Bodian,et al.  Lobular neoplasia: Long term risk of breast cancer and relation to other factors , 1996, Cancer.

[60]  J. Hendriks,et al.  REDUCTION OF BREAST CANCER MORTALITY THROUGH MASS SCREENING WITH MODERN MAMMOGRAPHY First Results of the Nijmegen Project, 1975 - 1981 , 1984, The Lancet.

[61]  D B Plewes,et al.  Comparison of breast magnetic resonance imaging, mammography, and ultrasound for surveillance of women at high risk for hereditary breast cancer. , 2001, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

[62]  L. Kapp,et al.  A critical look at the association of human genetic syndromes with sensitivity to ionizing radiation. , 1993, Seminars in cancer biology.

[63]  Kaiser Wa MRM promises earlier breast cancer diagnosis. , 1992 .

[64]  W. Kaiser,et al.  MR imaging of the breast: fast imaging sequences with and without Gd-DTPA. Preliminary observations. , 1989, Radiology.

[65]  R. Daffner,et al.  Magnetic resonance imaging in the diagnosis of breast disease. , 1986, AJR. American journal of roentgenology.

[66]  J. Otten,et al.  Mammographic breast density and risk of breast cancer: Masking bias or causality? , 1998, European Journal of Epidemiology.

[67]  A. Berg,et al.  Screening for Breast Cancer: Recommendations and Rationale , 2002, Annals of Internal Medicine.

[68]  W. Negendank,et al.  Studies of human tumors by MRS: A review , 1992, NMR in biomedicine.

[69]  S. Heywang-Köbrunner,et al.  MR-guided interventional breast procedures considering vacuum biopsy in particular. , 2002, European journal of radiology.

[70]  M D Schnall,et al.  Update of breast MR imaging architectural interpretation model. , 2001, Radiology.

[71]  G. Robbins,et al.  Long‐term followup of breast cancer patients: The 30‐year report , 1974, Cancer.

[72]  N M Hylton,et al.  Challenges to interpretation of breast MRI , 2001, Journal of magnetic resonance imaging : JMRI.

[73]  M. Hall-Craggs,et al.  Breast MR and the appearance of the normal and abnormal nipple. , 1997, Clinical radiology.

[74]  E. Thomson,et al.  Recommendations for follow-up care of individuals with an inherited predisposition to Cancer. II. BRCA1 and BRCA2 , 1997 .

[75]  A. Luini,et al.  Radiotherapy after breast-preserving surgery in women with localized cancer of the breast. , 1993, The New England journal of medicine.

[76]  Spratt Js,et al.  Assessing the risk of breast cancer. , 2000 .

[77]  P. Chappuis,et al.  Re: Magnetic resonance imaging and mammography in women with a hereditary risk of breast cancer. , 2001, Journal of the National Cancer Institute.

[78]  J Isola,et al.  The visibility of cancer on earlier mammograms in a population-based screening programme. , 1999, European journal of cancer.

[79]  E Grabbe,et al.  Magnetic Resonance Guided Localization and Biopsy of Suspicious Breast Lesions , 1998, Topics in magnetic resonance imaging : TMRI.

[80]  D. Fraker,et al.  Magnetic resonance imaging-guided biopsy of mammographically and clinically occult breast lesions. , 2002 .

[81]  S G Orel MR imaging of the breast. , 2000, Radiologic clinics of North America.

[82]  L J van Erning,et al.  MR characterization of suspicious breast lesions with a gadolinium-enhanced TurboFLASH subtraction technique. , 1994, Radiology.

[83]  H. Sittek,et al.  Multicenter study for the evaluation of a dedicated biopsy device for MR-guided vacuum biopsy of the breast , 2002, European Radiology.

[84]  Martin O. Leach,et al.  Technical Report of the International Working Group on Breast MRI , 1999, Journal of magnetic resonance imaging : JMRI.

[85]  C. Redmond,et al.  Reanalysis and results after 12 years of follow-up in a randomized clinical trial comparing total mastectomy with lumpectomy with or without irradiation in the treatment of breast cancer. , 1995, New England Journal of Medicine.

[86]  A. Baue Breast-conservation operations for treatment of cancer of the breast. , 1994, JAMA.

[87]  I. Gribbestad,et al.  Characterization of neoplastic and normal human breast tissues with in vivo 1H MR spectroscopy , 1999, Journal of magnetic resonance imaging : JMRI.

[88]  R. Gilles,et al.  Ductal carcinoma in situ: MR imaging-histopathologic correlation. , 1995, Radiology.

[89]  H. Sittek,et al.  MR-Guided vacuum biopsy of 206 contrast-enhancing breast lesions. , 2002, RöFo. Fortschritte auf dem Gebiet der Röntgenstrahlen und der bildgebenden Verfahren (Print).

[90]  S. Heywang,et al.  MR imaging of the breast with Gd-DTPA: use and limitations. , 1989, Radiology.

[91]  D. Schultz,et al.  Effect of breast magnetic resonance imaging on the clinical management of women with early-stage breast carcinoma. , 2002, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

[92]  S. Rankin,et al.  MRI of the breast. , 2000, The British journal of radiology.

[93]  R L Wahl,et al.  Current status of PET in breast cancer imaging, staging, and therapy. , 2001, Seminars in roentgenology.

[94]  C. D'Orsi,et al.  Clinical comparison of full-field digital mammography and screen-film mammography for detection of breast cancer. , 2002, AJR. American journal of roentgenology.

[95]  Rankin Sc,et al.  MRI of the breast. , 2000 .

[96]  B. Boné,et al.  Diagnostic Accuracy of Mammography and Contrast-Enhanced MR Imaging in 238 Histologically Verified Breast Lesions , 1997, Acta radiologica.

[97]  S E Harms,et al.  MR imaging of the breast with rotating delivery of excitation off resonance: clinical experience with pathologic correlation. , 1993, Radiology.

[98]  D. Berry,et al.  Probability of carrying a mutation of breast-ovarian cancer gene BRCA1 based on family history. , 1997, Journal of the National Cancer Institute.

[99]  S. Shapiro,et al.  Ten- to fourteen-year effect of screening on breast cancer mortality. , 1982, Journal of the National Cancer Institute.

[100]  J M Lewin,et al.  Comparison of full-field digital mammography with screen-film mammography for cancer detection: results of 4,945 paired examinations. , 2001, Radiology.

[101]  L. Esserman,et al.  Magnetic resonance imaging for primary breast cancer management: current role and new applications. , 2002, Endocrine-related cancer.

[102]  A. Heinig,et al.  Interventional MRI of the breast: lesion localisation and biopsy , 2000, European Radiology.

[103]  D. Fraker,et al.  Breast MR imaging in patients with axillary node metastases and unknown primary malignancy. , 1999, Radiology.

[104]  J O Barentsz,et al.  Magnetic resonance imaging and mammography in women with a hereditary risk of breast cancer. , 2001, Journal of the National Cancer Institute.

[105]  E. Pisano,et al.  Should FDG PET be used to decide whether a patient with an abnormal mammogram or breast finding at physical examination should undergo biopsy? , 2002, Academic radiology.

[106]  F. Holmes,et al.  Treatment of patients with isolated axillary nodal metastases from an occult primary carcinoma consistent with breast origin , 1990, Cancer.

[107]  K R Maravilla,et al.  Value of combined FDG PET and MR imaging in the evaluation of suspected recurrent local-regional breast cancer: preliminary experience. , 1999, Radiology.

[108]  J Chang-Claude,et al.  Genetic heterogeneity and penetrance analysis of the BRCA1 and BRCA2 genes in breast cancer families. The Breast Cancer Linkage Consortium. , 1998, American journal of human genetics.

[109]  M D Schnall,et al.  MR imaging in patients with nipple discharge: initial experience. , 2000, Radiology.

[110]  Mitchell D Schnall,et al.  MR imaging screening of the contralateral breast in patients with newly diagnosed breast cancer: preliminary results. , 2003, Radiology.

[111]  R. Tollenaar,et al.  MRI screening for breast cancer in women with high familial and genetic risk: First results of the Dutch MRI screening study (MRISC). , 2003 .

[112]  P Skaane Ultrasonography as adjunct to mammography in the evaluation of breast tumors. , 1999, Acta radiologica. Supplementum.

[113]  Roland Holland,et al.  Age-specific sensitivities of mammographic screening for breast cancer , 2005, Breast Cancer Research and Treatment.

[114]  W. Bautz,et al.  Magnetic resonance imaging and its role in the diagnosis of multicentric breast cancer. , 1998, Anticancer research.

[115]  A. Luini,et al.  Comparing Radical Mastectomy with Quadrantectomy, Axillary Dissection, and Radiotherapy in Patients with Small Cancers of the Breast , 1981 .

[116]  Lale Kostakoglu,et al.  Clinical role of FDG PET in evaluation of cancer patients. , 2003, Radiographics : a review publication of the Radiological Society of North America, Inc.