TLRs and tryptophan metabolism at the crossroad of immunoregulatory pathways

[1]  Y. Shai,et al.  Regulation of innate immune responses by transmembrane interactions: lessons from the TLR family. , 2014, Biochimica et biophysica acta.

[2]  M. Korppi,et al.  The Association of Genetic Variants in Toll-like Receptor 2 Subfamily With Allergy and Asthma After Hospitalization for Bronchiolitis in Infancy , 2014, The Pediatric infectious disease journal.

[3]  D. Coppola,et al.  TGF-β–inducible microRNA-183 silences tumor-associated natural killer cells , 2014, Proceedings of the National Academy of Sciences.

[4]  A. DeFranco,et al.  B Cell–Specific Loss of Lyn Kinase Leads to Autoimmunity , 2014, The Journal of Immunology.

[5]  Chin-Man Wang,et al.  Genetic variations in Toll-like receptors (TLRs 3/7/8) are associated with systemic lupus erythematosus in a Taiwanese population , 2014, Scientific Reports.

[6]  A. von Deimling,et al.  Constitutive IDO expression in human cancer is sustained by an autocrine signaling loop involving IL-6, STAT3 and the AHR , 2014, Oncotarget.

[7]  L. Joosten,et al.  TLR2 & Co: a critical analysis of the complex interactions between TLR2 and coreceptors , 2013, Journal of leukocyte biology.

[8]  D. Lauffenburger,et al.  HIV-1 infection induces strong production of IP-10 through TLR7/9-dependent pathways , 2013, AIDS.

[9]  R. Kaul,et al.  HIV-1 gp120 Induces TLR2- and TLR4-Mediated Innate Immune Activation in Human Female Genital Epithelium , 2013, The Journal of Immunology.

[10]  Lisong Shen,et al.  Activation of TLR4 signaling promotes gastric cancer progression by inducing mitochondrial ROS production , 2013, Cell Death and Disease.

[11]  E. Bahraoui,et al.  HIV-1 Tat Protein Induces the Production of IDO in Human Monocyte Derived-Dendritic Cells through a Direct Mechanism: Effect on T Cells Proliferation , 2013, Retrovirology.

[12]  Duen-Yi Huang,et al.  The Tyrosine Kinase Syk Differentially Regulates Toll-like Receptor Signaling Downstream of the Adaptor Molecules TRAF6 and TRAF3 , 2013, Science Signaling.

[13]  Qisheng Peng,et al.  A Physical Interaction Between the Adaptor Proteins DOK3 and DAP12 Is Required to Inhibit Lipopolysaccharide Signaling in Macrophages , 2013, Science Signaling.

[14]  P. Xie,et al.  TRAF molecules in cell signaling and in human diseases , 2013, Journal of molecular signaling.

[15]  Y. Gorgi,et al.  Polymorphisms of Toll-like receptor-4 and CD14 in systemic lupus erythematosus and rheumatoid arthritis , 2013, Biomarker Research.

[16]  L. Boon,et al.  High doses of CpG oligodeoxynucleotides stimulate a tolerogenic TLR9–TRIF pathway , 2013, Nature Communications.

[17]  C. Qian,et al.  Regulation of Toll‐like receptor signaling pathways in innate immune responses , 2013, Annals of the New York Academy of Sciences.

[18]  F. Quintana.  The aryl hydrocarbon receptor: a molecular pathway for the environmental control of the immune response , 2013, Immunology.

[19]  Gemma K. Alderton.  Signalling: New roles for TLR2 , 2012, Nature reviews. Immunology.

[20]  Atsuo Ochi,et al.  Toll-like receptor 7 regulates pancreatic carcinogenesis in mice and humans. , 2012, The Journal of clinical investigation.

[21]  Fernanda S. Oliveira,et al.  The role of innate immune signals in immunity to Brucella abortus , 2012, Front. Cell. Inf. Microbio..

[22]  A. Parker,et al.  STAT3-driven upregulation of TLR2 promotes gastric tumorigenesis independent of tumor inflammation. , 2012, Cancer cell.

[23]  E. Latz,et al.  HIV type 1 infection up-regulates TLR2 and TLR4 expression and function in vivo and in vitro. , 2012, AIDS research and human retroviruses.

[24]  J. Correale,et al.  Does helminth activation of toll-like receptors modulate immune response in multiple sclerosis patients? , 2012, Front. Cell. Inf. Microbio..

[25]  N. Bhardwaj,et al.  Activation of the noncanonical NF-κB pathway by HIV controls a dendritic cell immunoregulatory phenotype , 2012, Proceedings of the National Academy of Sciences.

[26]  A. De Luca,et al.  A GpC-Rich Oligonucleotide Acts on Plasmacytoid Dendritic Cells To Promote Immune Suppression , 2012, The Journal of Immunology.

[27]  U. Grohmann,et al.  Different Partners, Opposite Outcomes: A New Perspective of the Immunobiology of Indoleamine 2,3-Dioxygenase , 2012, Molecular medicine.

[28]  P. Kaye,et al.  IRF7 Regulates TLR2-Mediated Activation of Splenic CD11chi Dendritic Cells , 2012, PloS one.

[29]  A. Rudensky,et al.  Extrathymic Generation of Regulatory T Cells in Placental Mammals Mitigates Maternal-Fetal Conflict , 2012, Cell.

[30]  D. Singh,et al.  TGF‐β1 re‐programs TLR4 signaling in L. donovani infection: enhancement of SHP‐1 and ubiquitin‐editing enzyme A20 , 2012, Immunology and cell biology.

[31]  M. Volin,et al.  TLR5, a Novel and Unidentified Inflammatory Mediator in Rheumatoid Arthritis that Correlates with Disease Activity Score and Joint TNF-α Levels , 2012, The Journal of Immunology.

[32]  P. Cossart,et al.  Both TLR2 and TRIF Contribute to Interferon-β Production during Listeria Infection , 2012, PloS one.

[33]  Shao-Cong Sun.  The noncanonical NF‐κB pathway , 2012, Immunological reviews.

[34]  Theresa L. Chang,et al.  TLR2 Activation Enhances HIV Nuclear Import and Infection through T Cell Activation-Independent and -Dependent Pathways , 2012, The Journal of Immunology.

[35]  Hiroaki Ito,et al.  TREM‐2, triggering receptor expressed on myeloid cell‐2, negatively regulates TLR responses in dendritic cells , 2012, European journal of immunology.

[36]  K. Mills,et al.  TLR-dependent T cell activation in autoimmunity , 2011, Nature Reviews Immunology.

[37]  Y. Taketani,et al.  Toll-like receptor-3 ligation-induced indoleamine 2, 3-dioxygenase expression in human trophoblasts. , 2011, Endocrinology.

[38]  S. Bicciato,et al.  Indoleamine 2,3-dioxygenase is a signaling protein in long-term tolerance by dendritic cells , 2011, Nature Immunology.

[39]  Wanjun Chen.  IDO: more than an enzyme , 2011, Nature Immunology.

[40]  E. Park,et al.  Myeloid differentiation primary response protein 88 blockade upregulates indoleamine 2,3-dioxygenase expression in rheumatoid synovial fibroblasts , 2011, Experimental & Molecular Medicine.

[41]  Eric C. Sorenson,et al.  Imatinib potentiates anti-tumor T cell responses in gastrointestinal stromal tumor through the inhibition of Ido , 2012 .

[42]  Damien Chaussabel,et al.  IRF8 mutations and human dendritic-cell immunodeficiency. , 2011, The New England journal of medicine.

[43]  M. Karin,et al.  Expanding TRAF function: TRAF3 as a tri-faced immune regulator , 2011, Nature Reviews Immunology.

[44]  T. Chatila,et al.  The Toll-Like Receptor 2 Pathway Establishes Colonization by a Commensal of the Human Microbiota , 2011, Science.

[45]  R. Fimmers,et al.  Identification of IDO-Positive and IDO-Negative Human Dendritic Cells after Activation by Various Proinflammatory Stimuli , 2011, The Journal of Immunology.

[46]  Emma Leah.  Rheumatoid arthritis: Spontaneous release of cytokines from synovial tissue is blocked by anti-TLR2 , 2011, Nature Reviews Rheumatology.

[47]  A. Heitger.  Regulation of expression and function of IDO in human dendritic cells. , 2011, Current medicinal chemistry.

[48]  U. Grohmann,et al.  Using an ancient tool for igniting and propagating immune tolerance: IDO as an inducer and amplifier of regulatory T cell functions. , 2011, Current medicinal chemistry.

[49]  D. Davies,et al.  The structural biology of Toll-like receptors. , 2011, Structure.

[50]  E. Schlaepfer,et al.  TLR8 Activates HIV from Latently Infected Cells of Myeloid-Monocytic Origin Directly via the MAPK Pathway and from Latently Infected CD4+ T Cells Indirectly via TNF-α , 2011, The Journal of Immunology.

[51]  J. Wither,et al.  An intrinsic B‐cell defect supports autoimmunity in New Zealand black chromosome 13 congenic mice , 2011, European journal of immunology.

[52]  M. Si-Tahar,et al.  Innate Sensing of HIV-Infected Cells , 2011, PLoS pathogens.

[53]  J. Fechner,et al.  An Interaction between Kynurenine and the Aryl Hydrocarbon Receptor Can Generate Regulatory T Cells , 2010, The Journal of Immunology.

[54]  F. Aversa,et al.  Non-hematopoietic cells contribute to protective tolerance to Aspergillus fumigatus via a TRIF pathway converging on IDO , 2010, Cellular and Molecular Immunology.

[55]  M. Del Cornò,et al.  Dissecting TLR3 signalling in dendritic cells. , 2010, Immunobiology.

[56]  S. Gringhuis,et al.  HIV-1 exploits innate signaling by TLR8 and DC-SIGN for productive infection of dendritic cells , 2010, Nature Immunology.

[57]  P. Validire,et al.  Triggering of TLR7 and TLR8 expressed by human lung cancer cells induces cell survival and chemoresistance. , 2010, The Journal of clinical investigation.

[58]  M. Colonna,et al.  Unraveling the functions of plasmacytoid dendritic cells during viral infections, autoimmunity, and tolerance , 2010, Immunological reviews.

[59]  K. Moore,et al.  CD36 ligands promote sterile inflammation through assembly of a Toll-like receptor 4 and 6 heterodimer , 2009, Nature Immunology.

[60]  W. Heath,et al.  Dendritic cell subsets in primary and secondary T cell responses at body surfaces , 2009, Nature Immunology.

[61]  U. Grohmann,et al.  IDO Mediates TLR9-Driven Protection from Experimental Autoimmune Diabetes1 , 2009, The Journal of Immunology.

[62]  M. Benhamou,et al.  Inhibitory ITAMs as novel regulators of immunity , 2009, Immunological reviews.

[63]  D. Iliopoulos,et al.  The kinase Akt1 controls macrophage response to lipopolysaccharide by regulating microRNAs. , 2009, Immunity.

[64]  Q. Zhan,et al.  Blocking TLR2 Activity Attenuates Pulmonary Metastases of Tumor , 2009, PloS one.

[65]  Constance J Jeffery,et al.  Moonlighting proteins--an update. , 2009, Molecular bioSystems.

[66]  B. Hering,et al.  Upregulating CD4+CD25+FOXP3+ Regulatory T Cells in Pancreatic Lymph Nodes in Diabetic NOD Mice by Adjuvant Immunotherapy , 2009, Transplantation.

[67]  U. Grohmann,et al.  SOCS3 drives proteasomal degradation of indoleamine 2,3-dioxygenase (IDO) and antagonizes IDO-dependent tolerogenesis , 2008, Proceedings of the National Academy of Sciences.

[68]  T. P. Hofer,et al.  Tolerance induced via TLR2 and TLR4 in human dendritic cells: role of IRAK-1 , 2008, BMC Immunology.

[69]  T. Weichhart,et al.  The PI3K/Akt/mTOR pathway in innate immune cells: emerging therapeutic applications , 2008, Annals of the rheumatic diseases.

[70]  M. Feldmann,et al.  Inhibitors of TLR8 Reduce TNF Production from Human Rheumatoid Synovial Membrane Cultures1 , 2008, The Journal of Immunology.

[71]  J. Keats,et al.  Nonredundant and complementary functions of TRAF2 and TRAF3 in a ubiquitination cascade that activates NIK-dependent alternative NF-κB signaling , 2008, Nature Immunology.

[72]  Shizuo Akira,et al.  Toll‐like Receptor and RIG‐1‐like Receptor Signaling , 2008, Annals of the New York Academy of Sciences.

[73]  K. Stuhlmeier,et al.  The TSC-mTOR signaling pathway regulates the innate inflammatory response. , 2008, Immunity.

[74]  L. Boon,et al.  Cutting Edge: Autocrine TGF-β Sustains Default Tolerogenesis by IDO-Competent Dendritic Cells1 , 2008, The Journal of Immunology.

[75]  C. Spickett,et al.  Vascular cell responsiveness to Toll‐like receptor ligands in carotid atheroma , 2008, European journal of clinical investigation.

[76]  B. Pulendran,et al.  Toll-like receptor–mediated induction of type I interferon in plasmacytoid dendritic cells requires the rapamycin-sensitive PI(3)K-mTOR-p70S6K pathway , 2008, Nature Immunology.

[77]  A. DeFranco,et al.  Toll-like receptors activate innate and adaptive immunity by using dendritic cell-intrinsic and -extrinsic mechanisms. , 2008, Immunity.

[78]  Jie-Oh Lee,et al.  Structures of the toll-like receptor family and its ligand complexes. , 2008, Immunity.

[79]  T. Connor,et al.  Induction of indolamine 2,3-dioxygenase and kynurenine 3-monooxygenase in rat brain following a systemic inflammatory challenge: A role for IFN-γ? , 2008, Neuroscience Letters.

[80]  É. Vivier,et al.  Immunoreceptor tyrosine‐based inhibition motifs: a quest in the past and future , 2008, Immunological reviews.

[81]  M. Gilliet,et al.  Plasmacytoid dendritic cells: sensing nucleic acids in viral infection and autoimmune diseases , 2008, Nature Reviews Immunology.

[82]  Xuetao Cao,et al.  Phosphatase SHP-1 promotes TLR- and RIG-I-activated production of type I interferon by inhibiting the kinase IRAK1 , 2008, Nature Immunology.

[83]  H. Ploegh,et al.  UNC93B1 delivers nucleotide-sensing toll-like receptors to endolysosomes , 2008, Nature.

[84]  N. Horwood,et al.  Chemical inhibition of Src family kinases affects major LPS-activated pathways in primary human macrophages. , 2008, Molecular immunology.

[85]  Helen Y Wang,et al.  Toll-like receptors and immune regulation: implications for cancer therapy , 2008, Oncogene.

[86]  H. Yuasa,et al.  Evolution of Vertebrate Indoleamine 2,3-Dioxygenases , 2007, Journal of Molecular Evolution.

[87]  M. Feldmann,et al.  Key differences in TLR3/poly I:C signaling and cytokine induction by human primary cells: a phenomenon absent from murine cell systems. , 2007, Blood.

[88]  K. Maiese,et al.  The Src homology 2 domain tyrosine phosphatases SHP-1 and SHP-2: diversified control of cell growth, inflammation, and injury. , 2007, Histology and histopathology.

[89]  U. Grohmann,et al.  IDO and regulatory T cells: a role for reverse signalling and non-canonical NF-κB activation , 2007, Nature Reviews Immunology.

[90]  P. Tak,et al.  Noncanonical NF-κB signaling in dendritic cells is required for indoleamine 2,3-dioxygenase (IDO) induction and immune regulation , 2007 .

[91]  P. Tailor,et al.  The Interferon Regulatory Factor Family in Host Defense: Mechanism of Action* , 2007, Journal of Biological Chemistry.

[92]  C. Brosnan,et al.  Astrocyte Indoleamine 2,3-Dioxygenase Is Induced by the TLR3 Ligand Poly(I:C): Mechanism of Induction and Role in Antiviral Response , 2007, Journal of Virology.

[93]  M. Walker,et al.  TLR9 polymorphisms determine murine lymphocyte responses to Helicobacter: Results from a genome‐wide scan , 2007, European journal of immunology.

[94]  S. Akira,et al.  Murine Dendritic Cell Type I IFN Production Induced by Human IgG-RNA Immune Complexes Is IFN Regulatory Factor (IRF)5 and IRF7 Dependent and Is Required for IL-6 Production1 , 2007, The Journal of Immunology.

[95]  L. Boon,et al.  Reverse signaling through GITR ligand enables dexamethasone to activate IDO in allergy , 2007, Nature Medicine.

[96]  D. Fuchs,et al.  HIV inhibits CD4+ T-cell proliferation by inducing indoleamine 2,3-dioxygenase in plasmacytoid dendritic cells. , 2007, Blood.

[97]  S. Rhee,et al.  Role of TLR4 Tyrosine Phosphorylation in Signal Transduction and Endotoxin Tolerance* , 2007, Journal of Biological Chemistry.

[98]  D. Speiser,et al.  Human Effector CD8+ T Lymphocytes Express TLR3 as a Functional Coreceptor1 , 2006, The Journal of Immunology.

[99]  R. Maier,et al.  Endotoxin tolerance attenuates LPS‐induced TLR4 mobilization to lipid rafts: a condition reversed by PKC activation , 2006, Journal of Leukocyte Biology.

[100]  C. Qian,et al.  SHP-2 phosphatase negatively regulates the TRIF adaptor protein-dependent type I interferon and proinflammatory cytokine production. , 2006, Immunity.

[101]  E. Dejardin.  The alternative NF-kappaB pathway from biochemistry to biology: pitfalls and promises for future drug development. , 2006, Biochemical pharmacology.

[102]  G. Rasi,et al.  Thymosin alpha1 activates dendritic cell tryptophan catabolism and establishes a regulatory environment for balance of inflammation and tolerance. , 2006, Blood.

[103]  C. McCall,et al.  Induction of RelB Participates in Endotoxin Tolerance1 , 2006, The Journal of Immunology.

[104]  A. Bowie,et al.  The human adaptor SARM negatively regulates adaptor protein TRIF–dependent Toll-like receptor signaling , 2006, Nature Immunology.

[105]  V. Soumelis,et al.  From plasmacytoid to dendritic cell: Morphological and functional switches during plasmacytoid pre‐dendritic cell differentiation , 2006, European journal of immunology.

[106]  C. Biron,et al.  DAP12 Signaling Regulates Plasmacytoid Dendritic Cell Homeostasis and Down-Modulates Their Function during Viral Infection1 , 2006, The Journal of Immunology.

[107]  S. Akira,et al.  Immunoprivileged status of the liver is controlled by Toll-like receptor 3 signaling. , 2006, The Journal of clinical investigation.

[108]  O. Bakke,et al.  Toll‐like receptor 3 associates with c‐Src tyrosine kinase on endosomes to initiate antiviral signaling , 2006, The EMBO journal.

[109]  U. Grohmann,et al.  The Combined Effects of Tryptophan Starvation and Tryptophan Catabolites Down-Regulate T Cell Receptor ζ-Chain and Induce a Regulatory Phenotype in Naive T Cells1 , 2006, The Journal of Immunology.

[110]  L. Joosten,et al.  Identification of Small Heat Shock Protein B8 (HSP22) as a Novel TLR4 Ligand and Potential Involvement in the Pathogenesis of Rheumatoid Arthritis1 , 2006, The Journal of Immunology.

[111]  K. Ozato,et al.  IRF-8/Interferon (IFN) Consensus Sequence-binding Protein Is Involved in Toll-like Receptor (TLR) Signaling and Contributes to the Cross-talk between TLR and IFN-γ Signaling Pathways* , 2006, Journal of Biological Chemistry.

[112]  Katia Perruccio,et al.  Toward the identification of a tolerogenic signature in IDO-competent dendritic cells. , 2006, Blood.

[113]  H. Oberg,et al.  Direct Costimulatory Effect of TLR3 Ligand Poly(I:C) on Human γδ T Lymphocytes1 , 2006, The Journal of Immunology.

[114]  A. Shahangian,et al.  Critical role of TRAF3 in the Toll-like receptor-dependent and -independent antiviral response , 2006, Nature.

[115]  P. Puccetti,et al.  Toll‐like receptor 9‐mediated induction of the immunosuppressive pathway of tryptophan catabolism , 2006, European journal of immunology.

[116]  D. Busch,et al.  Systemic application of CpG‐rich DNA suppresses adaptive T cell immunity via induction of IDO , 2006, European journal of immunology.

[117]  A. Sher,et al.  TLR9 regulates Th1 responses and cooperates with TLR2 in mediating optimal resistance to Mycobacterium tuberculosis , 2005, The Journal of experimental medicine.

[118]  S. Akira,et al.  Suppressor of cytokine signaling-1 selectively inhibits LPS-induced IL-6 production by regulating JAK-STAT. , 2005, Proceedings of the National Academy of Sciences of the United States of America.

[119]  Michael Platten,et al.  Treatment of Autoimmune Neuroinflammation with a Synthetic Tryptophan Metabolite , 2005, Science.

[120]  K. Honda,et al.  Negative regulation of Toll-like-receptor signaling by IRF-4. , 2005, Proceedings of the National Academy of Sciences of the United States of America.

[121]  S. Akira,et al.  Nucleic acids of mammalian origin can act as endogenous ligands for Toll-like receptors and may promote systemic lupus erythematosus , 2005, The Journal of experimental medicine.

[122]  P. Moynagh.  TLR signalling and activation of IRFs: revisiting old friends from the NF-kappaB pathway. , 2005, Trends in immunology.

[123]  R. Gay,et al.  RNA released from necrotic synovial fluid cells activates rheumatoid arthritis synovial fibroblasts via Toll-like receptor 3. , 2005, Arthritis and rheumatism.

[124]  L. Joosten,et al.  The expression of toll-like receptors 3 and 7 in rheumatoid arthritis synovium is increased and costimulation of toll-like receptors 3, 4, and 7/8 results in synergistic cytokine production by dendritic cells. , 2005, Arthritis and rheumatism.

[125]  M. Maurer,et al.  TLR3-induced activation of mast cells modulates CD8+ T-cell recruitment. , 2005, Blood.

[126]  F. Liew,et al.  Negative regulation of Toll-like receptor-mediated immune responses , 2005, Nature Reviews Immunology.

[127]  Tomoko Yamaguchi,et al.  Mice lacking the IFN-γ receptor or fyn develop severe experimental autoimmune uveoretinitis characterized by different immune responses , 2005, Immunogenetics.

[128]  Hideo Negishi,et al.  IRF-7 is the master regulator of type-I interferon-dependent immune responses , 2005, Nature.

[129]  S. Akira,et al.  Sequence-specific potent induction of IFN-α by short interfering RNA in plasmacytoid dendritic cells through TLR7 , 2005, Nature Medicine.

[130]  D. Golenbock,et al.  Human lupus autoantibody-DNA complexes activate DCs through cooperation of CD32 and TLR9. , 2005, The Journal of clinical investigation.

[131]  Cory M. Robinson,et al.  The Role of IFN-γ and TNF-α-Responsive Regulatory Elements in the Synergistic Induction of Indoleamine Dioxygenase , 2005 .

[132]  G. Trinchieri,et al.  Plasmacytoid dendritic cells in immunity , 2004, Nature Immunology.

[133]  U. Grohmann,et al.  CTLA-4–Ig Activates Forkhead Transcription Factors and Protects Dendritic Cells from Oxidative Stress in Nonobese Diabetic Mice , 2004, The Journal of experimental medicine.

[134]  Angela Panoskaltsis-Mortari,et al.  Human Plasmacytoid Dendritic Cells Activated by CpG Oligodeoxynucleotides Induce the Generation of CD4+CD25+ Regulatory T Cells1 , 2004, The Journal of Immunology.

[135]  D. Munn,et al.  Ido expression by dendritic cells: tolerance and tryptophan catabolism , 2004, Nature Reviews Immunology.

[136]  G. Trinchieri,et al.  Murine Plasmacytoid Dendritic Cells Initiate the Immunosuppressive Pathway of Tryptophan Catabolism in Response to CD200 Receptor Engagement1 , 2004, The Journal of Immunology.

[137]  Ruslan Medzhitov,et al.  Recognition of Commensal Microflora by Toll-Like Receptors Is Required for Intestinal Homeostasis , 2004, Cell.

[138]  E. Silverman,et al.  Toll-like receptor 6 gene (TLR6): single-nucleotide polymorphism frequencies and preliminary association with the diagnosis of asthma , 2004, Genes and Immunity.

[139]  K. Ishii,et al.  Toll-Like Receptor 9 Signaling Activates NF-κB through IFN Regulatory Factor-8/IFN Consensus Sequence Binding Protein in Dendritic Cells1 , 2004, The Journal of Immunology.

[140]  M. Karin,et al.  The two NF-κB activation pathways and their role in innate and adaptive immunity , 2004 .

[141]  D. Fruman.  Phosphoinositide 3-kinase and its targets in B-cell and T-cell signaling. , 2004, Current opinion in immunology.

[142]  J. Simon,et al.  Hyaluronan Fragments Stimulate Endothelial Recognition of Injury through TLR4* , 2004, Journal of Biological Chemistry.

[143]  N. Sarvetnick,et al.  Homeostatic Expansion of T Cells during Immune Insufficiency Generates Autoimmunity , 2004, Cell.

[144]  D. Klinman.  Immunotherapeutic uses of CpG oligodeoxynucleotides , 2004, Nature Reviews Immunology.

[145]  Shizuo Akira,et al.  Innate Antiviral Responses by Means of TLR7-Mediated Recognition of Single-Stranded RNA , 2004, Science.

[146]  D. Nowak,et al.  Toll-like receptor 2 as a major gene for asthma in children of European farmers. , 2004, The Journal of allergy and clinical immunology.

[147]  S. Akira,et al.  IL-10-inducible Bcl-3 negatively regulates LPS-induced TNF-α production in macrophages , 2003 .

[148]  M. Shlomchik,et al.  Activation of autoreactive B cells by CpG dsDNA. , 2003, Immunity.

[149]  U. Grohmann,et al.  Modulation of tryptophan catabolism by regulatory T cells , 2003, Nature Immunology.

[150]  S. Akira,et al.  TRAM is specifically involved in the Toll-like receptor 4–mediated MyD88-independent signaling pathway , 2003, Nature Immunology.

[151]  E. Jimi,et al.  Receptor Activator of NF-κB Ligand Stimulates Recruitment of SHP-1 to the Complex Containing TNFR-Associated Factor 6 That Regulates Osteoclastogenesis1 , 2003, The Journal of Immunology.

[152]  S. Akira,et al.  Toll-like Receptor 9–mediated Recognition of Herpes Simplex Virus-2 by Plasmacytoid Dendritic Cells , 2003, The Journal of experimental medicine.

[153]  Xianwu Li,et al.  Phosphoinositide 3 Kinase Mediates Toll-Like Receptor 4-Induced Activation of NF-κB in Endothelial Cells , 2003, Infection and Immunity.

[154]  S. Akira,et al.  Role of Adaptor TRIF in the MyD88-Independent Toll-Like Receptor Signaling Pathway , 2003, Science.

[155]  K. Honda,et al.  Essential role of IRF-3 in lipopolysaccharide-induced interferon-beta gene expression and endotoxin shock. , 2003, Biochemical and biophysical research communications.

[156]  U. Grohmann,et al.  A Defect in Tryptophan Catabolism Impairs Tolerance in Nonobese Diabetic Mice , 2003, The Journal of experimental medicine.

[157]  Stefan W Krause,et al.  Species-specific Regulation of Toll-like Receptor 3 Genes in Men and Mice* , 2003, Journal of Biological Chemistry.

[158]  B. Neel,et al.  The 'Shp'ing news: SH2 domain-containing tyrosine phosphatases in cell signaling. , 2003, Trends in biochemical sciences.

[159]  U. Grohmann,et al.  Tolerance, DCs and tryptophan: much ado about IDO. , 2003, Trends in immunology.

[160]  K. Vuori,et al.  Phosphatidylinositol 3‐kinase is involved in Toll‐like receptor 4‐mediated cytokine expression in mouse macrophages , 2003, European journal of immunology.

[161]  K. Ozato,et al.  Cutting Edge: IFN Consensus Sequence Binding Protein/IFN Regulatory Factor 8 Drives the Development of Type I IFN-Producing Plasmacytoid Dendritic Cells 1 , 2003, The Journal of Immunology.

[162]  U. Grohmann,et al.  CTLA-4–Ig regulates tryptophan catabolism in vivo , 2002, Nature Immunology.

[163]  L. Kwak,et al.  Toll-Like Receptor 4-Dependent Activation of Dendritic Cells by β-Defensin 2 , 2002, Science.

[164]  K. Miyake,et al.  Possible Involvement of Toll-Like Receptor 4 in Endothelial Cell Activation of Larger Vessels in Response to Lipopolysaccharide , 2002, Pathobiology.

[165]  N. Mackman,et al.  The Phosphatidylinositol 3-Kinase-Akt Pathway Limits Lipopolysaccharide Activation of Signaling Pathways and Expression of Inflammatory Mediators in Human Monocytic Cells* , 2002, The Journal of Biological Chemistry.

[166]  A. Krieg.  A role for Toll in autoimmunity , 2002, Nature Immunology.

[167]  T. Giese,et al.  Quantitative Expression of Toll-Like Receptor 1–10 mRNA in Cellular Subsets of Human Peripheral Blood Mononuclear Cells and Sensitivity to CpG Oligodeoxynucleotides1 , 2002, The Journal of Immunology.

[168]  M. Shlomchik,et al.  Chromatin–IgG complexes activate B cells by dual engagement of IgM and Toll-like receptors , 2002, Nature.

[169]  S. Ross,et al.  Murine retroviruses activate B cells via interaction with toll-like receptor 4 , 2002, Proceedings of the National Academy of Sciences of the United States of America.

[170]  P. Robbins,et al.  Indoleamine 2,3-dioxygenase expression in transplanted NOD Islets prolongs graft survival after adoptive transfer of diabetogenic splenocytes. , 2002, Diabetes.

[171]  P. Godowski,et al.  Tissue Expression of Human Toll-Like Receptors and Differential Regulation of Toll-Like Receptor mRNAs in Leukocytes in Response to Microbes, Their Products, and Cytokines , 2002, The Journal of Immunology.

[172]  T. Ahrens,et al.  Oligosaccharides of Hyaluronan Activate Dendritic Cells via Toll-like Receptor 4 , 2002, The Journal of experimental medicine.

[173]  A. Billiau,et al.  Modes of action of Freund’s adjuvants in experimental models of autoimmune diseases , 2001, Journal of leukocyte biology.

[174]  Ruslan Medzhitov,et al.  Toll-like receptors and innate immunity , 2001, Nature Reviews Immunology.

[175]  R. Flavell,et al.  Recognition of double-stranded RNA and activation of NF-κB by Toll-like receptor 3 , 2001, Nature.

[176]  N. Kadowaki,et al.  Subsets of Human Dendritic Cell Precursors Express Different Toll-like Receptors and Respond to Different Microbial Antigens , 2001, The Journal of experimental medicine.

[177]  D R Alessi,et al.  PKB/Akt: a key mediator of cell proliferation, survival and insulin responses? , 2001, Journal of cell science.

[178]  R. Ravid,et al.  Bacterial peptidoglycan and immune reactivity in the central nervous system in multiple sclerosis. , 2001, Brain : a journal of neurology.

[179]  S. Akira,et al.  Synergy and Cross-Tolerance Between Toll-Like Receptor (TLR) 2- and TLR4-Mediated Signaling Pathways1 , 2000, The Journal of Immunology.

[180]  S. Akira,et al.  A Toll-like receptor recognizes bacterial DNA , 2000, Nature.

[181]  A. Aderem,et al.  The repertoire for pattern recognition of pathogens by the innate immune system is defined by cooperation between toll-like receptors. , 2000, Proceedings of the National Academy of Sciences of the United States of America.

[182]  D. Podolsky,et al.  Differential Alteration in Intestinal Epithelial Cell Expression of Toll-Like Receptor 3 (TLR3) and TLR4 in Inflammatory Bowel Disease , 2000, Infection and Immunity.

[183]  L. Lanier,et al.  The ITAM-bearing transmembrane adaptor DAP12 in lymphoid and myeloid cell function. , 2000, Immunology today.

[184]  Douglas T. Golenbock,et al.  Pattern recognition receptors TLR4 and CD14 mediate response to respiratory syncytial virus , 2000, Nature Immunology.

[185]  B. Beutler,et al.  Three novel mammalian toll-like receptors: gene structure, expression, and evolution. , 2000, European cytokine network.

[186]  U. Grohmann,et al.  IFN-γ Inhibits Presentation of a Tumor/Self Peptide by CD8α− Dendritic Cells Via Potentiation of the CD8α+ Subset1 , 2000, The Journal of Immunology.

[187]  M. Du,et al.  Analysis of transcription factors regulating induction of indoleamine 2,3-dioxygenase by IFN-gamma. , 2000, Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research.

[188]  H. Kolb,et al.  Cutting Edge: Heat Shock Protein 60 Is a Putative Endogenous Ligand of the Toll-Like Receptor-4 Complex1 , 2000, The Journal of Immunology.

[189]  S. Akira,et al.  Unresponsiveness of MyD88-deficient mice to endotoxin. , 1999, Immunity.

[190]  Yoshinori Nagai,et al.  MD-2, a Molecule that Confers Lipopolysaccharide Responsiveness on Toll-like Receptor 4 , 1999, The Journal of experimental medicine.

[191]  M. Díaz-Guerra,et al.  Negative regulation by protein tyrosine phosphatase of IFN-gamma-dependent expression of inducible nitric oxide synthase. , 1999, Journal of immunology.

[192]  B. Groth.  The evolution of self-tolerance: a new cell arises to meet the challenge of self-reactivity. , 1998 .

[193]  D. Munn,et al.  Prevention of allogeneic fetal rejection by tryptophan catabolism. , 1998, Science.

[194]  T. Yagi,et al.  Suppression of autoimmune disease and of massive lymphadenopathy in MRL/Mp-lpr/lpr mice lacking tyrosine kinase Fyn (p59fyn). , 1997, Journal of immunology.

[195]  B. Hissong,et al.  Potentiation of interferon-induced indoleamine 2,3-dioxygenase mRNA in human mononuclear phagocytes by lipopolysaccharide and interleukin-1. , 1997, Journal of Interferon and Cytokine Research.

[196]  Milton W. Taylor,et al.  Importance of the Two Interferon-stimulated Response Element (ISRE) Sequences in the Regulation of the Human Indoleamine 2,3-Dioxygenase Gene* , 1996, The Journal of Biological Chemistry.

[197]  Sohanl . Gupta,et al.  Cooperative Role of Interferon Regulatory Factor 1 and p91 (STAT1) Response Elements in Interferon-γ-inducible Expression of Human Indoleamine 2,3-Dioxygenase Gene* , 1996, The Journal of Biological Chemistry.

[198]  R. Ulevitch,et al.  CD14, a receptor for complexes of lipopolysaccharide (LPS) and LPS binding protein. , 1990, Science.

[199]  R. Ulevitch,et al.  Lipopolysaccharide (LPS) binding protein opsonizes LPS-bearing particles for recognition by a novel receptor on macrophages , 1989, The Journal of experimental medicine.

[200]  R. Ulevitch,et al.  Isolation of a lipopolysaccharide-binding acute phase reactant from rabbit serum , 1986, The Journal of experimental medicine.

[201]  O. Hayaishi,et al.  Studies on oxygenases; enzymatic formation of kynurenine from tryptophan. , 1957, The Journal of biological chemistry.

[202]  Xiao-yan Tang,et al.  TLR4 signaling promotes immune escape of human colon cancer cells by inducing immunosuppressive cytokines and apoptosis resistance. , 2012, Oncology research.

[203]  U. Grohmann,et al.  Indoleamine 2,3-dioxygenase and regulatory function: tryptophan starvation and beyond. , 2011, Methods in molecular biology.

[204]  D. Munn,et al.  Creating immune privilege: active local suppression that benefits friends, but protects foes , 2008, Nature Reviews Immunology.

[205]  Tomohiro Watanabe,et al.  Signalling pathways and molecular interactions of NOD1 and NOD2 , 2006, Nature Reviews Immunology.

[206]  Tomoki Ito,et al.  Plasmacytoid dendritic cell precursors/type I interferon-producing cells sense viral infection by Toll-like receptor (TLR) 7 and TLR9 , 2004, Springer Seminars in Immunopathology.

[207]  A. DeFranco,et al.  Signaling mutations and autoimmunity. , 2003, Current directions in autoimmunity.

[208]  S. Akira,et al.  Toll-like receptors. , 2003, Annual review of immunology.

[209]  John F. Timms,et al.  Cellular function of phosphoinositide 3-kinases: Implications for development, immunity, homeostasis, and cancer , 2001 .

[210]  M. Karin,et al.  Phosphorylation meets ubiquitination: the control of NF-[kappa]B activity. , 2000, Annual review of immunology.

[211]  G. Franzoso,et al.  Structure, regulation and function of NF-kappa B. , 1994, Annual review of cell biology.